PMID: 

Conf Proc IEEE Eng Med Biol Soc. 2007 ;2007:4747-50. PMID: 18003066

Abstract Title: 

Adaptation of human brain bioelectrical activity to low-level microwave.

Abstract: 

The experiments of adaptation of the human brain bioelectrical activity were carried out on a group of 14 healthy volunteers exposed to 450 MHz microwave radiation modulated at 40 Hz frequencies. The field power density at the scalp was 0.16 mW/cm(2). Results of the study indicate that adaptation effect of human brain to low-level microwave exposure is evident. The initial increase of EEG power was compensated and even overcompensated. The adaptation phenomena were obvious in EEG alpha and beta rhythms..

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PMID: 

Coll Antropol. 2011 Dec ;35(4):1259-64. PMID: 22397269

Abstract Title: 

Effect of electromagnetic radiofrequency radiation on the rats' brain, liver and kidney cells measured by comet assay.

Abstract: 

The goal of study was to evaluate DNA damage in rat's renal, liver and brain cells after in vivo exposure to radiofrequency/microwave (Rf/Mw) radiation of cellular phone frequencies range. To determine DNA damage, a single cell gel electrophoresis/comet assay was used. Wistar rats (male, 12 week old, approximate body weight 350 g) (N = 9) were exposed to the carrier frequency of 915 MHz with Global System Mobile signal modulation (GSM), power density of 2.4 W/m2, whole body average specific absorption rate SAR of 0.6 W/kg. The animals were irradiated for one hour/day, seven days/week during two weeks period. The exposure set-up was Gigahertz Transversal Electromagnetic Mode Cell (GTEM–cell). Sham irradiated controls (N = 9) were apart of the study. The body temperature was measured before and after exposure. There were no differences in temperature in between control and treated animals. Comet assay parameters such as the tail length and tail intensity were evaluated. In comparison with tail length in controls (13.5 +/- 0.7 microm), the tail was slightly elongated in brain cells of irradiated animals (14.0 +/- 0.3 microm). The tail length obtained for liver (14.5 +/- 0.3 microm) and kidney (13.9 +/- 0.5 microm) homogenates notably differs in comparison with matched sham controls (13.6 +/- 0.3 microm) and (12.9 +/- 0.9 microm). Differences in tail intensity between control and exposed animals were not significant. The results of this study suggest that, under the experimental conditions applied, repeated 915 MHz irradiation could be a cause of DNA breaks in renal and liver cells, but not affect the cell genome at the higher extent compared to the basal damage.

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PMID: 

Toxicol Lett. 2004 Dec 1 ;154(1-2):125-32. PMID: 15475186

Abstract Title: 

Blood-forming system in rats after whole-body microwave exposure; reference to the lymphocytes.

Abstract: 

The influence of 2.45 GHz microwave (RF/MW) irradiation on blood-forming cells after whole-body irradiation of rats was investigated. The exposures were conducted with a field power density of 5-10 mW/cm2, and whole-body average specific absorption rate (SAR) of 1-2 W/kg. Four experimental subgroups were created and irradiated 2, 8, 15 or 30 days, for 2 h a day, 7 days a week. Concurrent sham-exposed rats were also included in the study. The cell response was assessed by number and type of the bone marrow nuclear cells and peripheral blood white cells using standard laboratory methods. Significant decrease in lymphoblast count was obtained at 15 and 30th experimental day (P

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PMID: 

Mutagenesis. 2004 Sep ;19(5):361-4. PMID: 15388808

Abstract Title: 

Investigation of the genotoxic effect of microwave irradiation in rat bone marrow cells: in vivo exposure.

Abstract: 

An in vivo mammalian cytogenetic test (the erythrocyte micronucleus assay) was used to investigate the extent of genetic damage in bone marrow red cells of rats exposed to radiofrequency/microwave (RF/MW) radiation. Wistar rats (n = 40) were exposed to a 2.45 GHz continuous RF/MW field for 2 h daily, 7 days a week, at a power density of 5-10 mW/cm(2). The whole body average specific absorption rate (SARs) was calculated to be 1.25 +/- 0.36 (SE) W/kg. Four subgroups were irradiated for 4, 16, 30 and 60 h. Sham-exposed controls (n = 24) were included in the study. The animals of each treated subgroup were killed on the final day of irradiation. Bone marrow smears were examined to determine the extent of genotoxicity after particular treatment times. The results were statistically evaluated using non-parametric Mann-Whitney and Kruskal-Wallis tests. In comparison with the sham-exposed subgroups, the findings of polychromatic erythrocytes (PCE) revealed significant differences (P

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PMID: 

Mutat Res. 2002 Nov 26 ;521(1-2):73-9. PMID: 12438005

Abstract Title: 

Micronucleus induction after whole-body microwave irradiation of rats.

Abstract: 

Adult male Wistar rats were exposed for 2 h a day, 7 days a week for up to 30 days to continuous 2,450 MHz radiofrequency microwave (rf/MW) radiation at a power density of 5-10 mW/cm(2). Sham-exposed rats were used as controls. After ether anesthesia, experimental animals were euthanized on the final irradiation day for each treated group. Peripheral blood smears were examined for the extent of genotoxicity, as indicated by the presence of micronuclei in polychromatic erythrocytes (PCEs). The results for the time-course of PCEs indicated significant differences (P

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PMID: 

Int J Hyg Environ Health. 2001 Nov ;204(2-3):133-8. PMID: 11759156

Abstract Title: 

Multinucleated giant cell appearance after whole body microwave irradiation of rats.

Abstract: 

Multinucleated giant cells are common for some chronic inflammatory processes in the lung. These cells are formed by fusion of macrophages, but how the process relates to the kinetics of alveolar macrophage generation is not clear. This study investigated the influence of 2450 MHz microwave irradiation on alveolar macrophage kinetics and formation of multinucleated giant cells after whole body irradiation of rats. The range of electromagnetic radiation was selected as 2450 MHz microwaves at a power density of 5-15 mW/cm2. A group of experimental animals was divided in four subgroups that received 2, 8, 13 and 22 irradiation treatments of two hours each. The animals were killed on experimental days 1, 8, 16, and 30. Free lung cell population was obtained by bronchoalveolar lavage. Cell response to the selected irradiation level was followed quantitatively, qualitatively and morphologically using standard laboratory methods. Total cell number retrieved by lavage slightly decreased in treated animals showing time- and dose-dependence. Cell viability did not significantly change in the irradiated animal group (G2) as compared with the control group (G1). Multinucleated cells significantly increased (p

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PMID: 

Int J Radiat Biol. 2010 Jul ;86(7):529-41. PMID: 20545575

Abstract Title: 

Indication of cocarcinogenic potential of chronic UMTS-modulated radiofrequency exposure in an ethylnitrosourea mouse model.

Abstract: 

PURPOSE: To evaluate putative effects on tumour susceptibility in mice exposed to a UMTS (universal mobile telecommunications system) test signal for up to 24 months, commencing with embryo-fetal exposure.MATERIAL AND METHODS: Animals were exposed to UMTS fields with intensities of 0, 4.8, and 48 W/m(2), the low-dose group (4.8 W/m(2)) was subjected to additional prenatal ethylnitrosourea treatment (40 mg ENU/kg body weight).RESULTS: The high-level UMTS exposure (48 W/m(2)), the sham exposure, and the cage control groups showed comparable tumour incidences in the protocol organs. In contrast, the ENU-treated group UMTS-exposed at 4.8 W/m(2) displayed an enhanced lung tumour rate and an increased incidence of lung carcinomas as compared to the controls treated with ENU only. Furthermore, tumour multiplicity of the lung carcinomas was increased and the number of metastasising lung tumours was doubled in the ENU/UMTS group as compared to the ENU control group.CONCLUSION: This pilot study indicates a cocarcinogenic effect of lifelong UMTS exposure (4.8 W/m(2)) in female B6C3F1 descendants subjected to pretreatment with ethylnitrosourea.

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PMID: 

Nutrients. 2019 Aug 10 ;11(8). Epub 2019 Aug 10. PMID: 31405122

Abstract Title: 

Health Benefits ofCP2305 Tablets in Young Adults Exposed to Chronic Stress: A Randomized, Double-Blind, Placebo-Controlled Study.

Abstract: 

Short-term administration ofCP2305 improves stress-associated symptoms and clinical symptoms in healthy young adults and in patients with irritable bowel syndrome, respectively. We evaluated the efficacy and health benefits of the long-term use of a tablet containing heat-inactivated, washedCP2305 (CP2305) in healthy young adults. Sixty Japanese medical students (41 men and 19 women) preparing for the national examination for medical practitioners ingested CP2305-containing or placebo tablets once daily for 24 weeks. Intake of the CP2305 tablet significantly reduced anxiety and sleep disturbance relative to placebo, as quantitated by the Spielberger State-Trait Anxiety Inventory and the Pittsburgh Sleep Quality Index. Single-channel sleep electroencephalograms show that CP2305 significantly shortened sleep latency and wake time after sleep onset and increased the delta power ratio in the first sleep cycle. CP2305 also significantly lowered salivary chromogranin A levels compared with placebo. Furthermore, 16S rRNA gene sequencing of participant feces demonstrated that CP2305 administration attenuated the stress-induced decline ofspp. and the stress-induced elevation ofspp. We conclude that the long-term use of CP2305-containing tablets may improve the mental state, sleep quality, and gut microbiota of healthy adults under stressful conditions.

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PMID: 

J Med Microbiol. 2019 Oct ;68(10):1560-1572. Epub 2019 Aug 22. PMID: 31460863

Abstract Title: 

Application of63 AM supernatant toinfected wounds prevents sepsis in murine models of thermal injury and dorsal excision.

Abstract: 

. Severely burned patients are susceptible to bacterial infection within their burn wounds, which frequently leads to sepsis, multiple organ failure and death. The opportunistic pathogen, an organism inherently resistant to multiple antibiotics, is a common cause of sepsis in these patients.. Development of a topical treatment unrelated to conventional antibiotics is essential for prevention ofinfection and sepsis, leading to a role for the direct application of probiotics or their by-products.. We examined the effectiveness of 20× concentrated supernatant fromstrain 63 AM (LgCS) grown in de Man, Rogosa and Sharpe broth in inhibitingbiofilms, as well as in reducing wound bioburden andsepsis.. LgCS inhibited the growth ofstrain PAO1, prevented its biofilm development and eliminated partially developed PAO1 biofilms. In the murine model of thermal injury, a single injection of LgCS following injury and PAO1 infection reduced mortality to 0 % and prevented systemic spread (sepsis). Furthermore, a second injection of LgCS 24 h after the first eliminated PAO1 from the wound. In the murine dorsal excision infection model, either LgCS or ceftazidime treatment of the PAO1-infected wound significantly reduced the mortality rate among infected mice, while combining LgCS with ceftazidime eliminated mortality.. These results suggest the potential of LgCS in preventing sepsis frominfection in severely burned and other immunocompromised patients.

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PMID: 

Pathogens. 2019 Sep 12 ;8(3). Epub 2019 Sep 12. PMID: 31547398

Abstract Title: 

Antifungal and Antivirulence Activity of VaginalSpp. Products againstVaginal Isolates.

Abstract: 

yeasts are generally found in the vaginal microbiota; however, disruption of the balance maintained by host factors and microorganisms results in vulvovaginal candidiasis (VVC). This study evaluated the antagonistic activity of vaginalspp. onto verify whether active compounds ofspp. had antifungal and antivirulence activity. The antagonism assay showed that 15 out of 20strains had an inhibitory effect onBiosurfactants displayed surface-tension-reducing activity, with the best value obtained for1.ATCC 9595,ATCC 4356, and11 produced biosurfactants that decreasedadhesion and disrupted biofilm formation. The best results were obtained in the pre-incubation assay for1 and11. Overall,strains showed significant anti-activity, and their biosurfactants exhibited considerable anti-adhesion and antibiofilm activity against. To be considered safe for use in vivo, the safety of biosurfactant (BS) should be investigated using cytotoxicity assays.

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