PMID: 

J Perianesth Nurs. 2019 Jul 19. Epub 2019 Jul 19. PMID: 31331803

Abstract Title: 

Efficacy of Guided Imagery for Postoperative Symptoms, Sleep Quality, Anxiety, and Satisfaction Regarding Nursing Care: A Randomized Controlled Study.

Abstract: 

PURPOSE: The purpose of this study was to determine the effects of perioperatively applied guided imagery on nausea, satisfaction, and anxiety.DESIGN: This is a prospective randomized controlled study.METHODS: In addition to standard treatment and nursing care, guided imagery was applied to the intervention group once in the preoperative period, once on the first day of postoperative period, twice in the second and third days, for six times in total. Only standard treatment and nursing care were given to the patients of the control group.FINDINGS: Anxiety and intensity of pain were significantly higher in the control group than the intervention group, and the level of satisfaction and sleep quality were lower in the control group than the intervention group.CONCLUSIONS: Results support that guided imagery can be useful in improving perianesthetic symptoms and can be a part of nursing care.

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PMID: 

Clin J Oncol Nurs. 2019 Oct 1 ;23(5):E87-E92. PMID: 31538976

Abstract Title: 

Guided Imagery: Reducing Anxiety, Depression, and Selected Side Effects Associated With Chemotherapy.

Abstract: 

BACKGROUND: Cancer treatment can be a great source of anxiety and depression for patients. Patients who experience anxiety and depression may be treated with a variety of nonpharmacologic treatments, such as guided imagery.OBJECTIVES: The purpose of this article is to determine the effect of guided imagery on patients' anxiety, depression, and other selected side effects prompted by chemotherapy.METHODS: This pre- and postintervention assessment randomly selected patients with various types of cancer who were undergoing chemotherapy to listen to a guided imagery audio file for 20 minutes per day for one week. Data collection included a demographic questionnaire, the Hospital Anxiety and Depression Scale, and the Symptom Distress Scale.FINDINGS: A significant decrease in anxiety and depression was noted in the intervention group compared to the control group. No reduction in the mean score for anxiety and depression was observed postintervention for the control group. In addition, patients in the intervention group showed improvement in all side effect categories. Patients in the intervention group reported the greatest rate of improvement in the items of pain, insomnia, appetite, and nausea.

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PMID: 

Exp Ther Med. 2019 Oct ;18(4):3053-3061. Epub 2019 Aug 14. PMID: 31572545

Abstract Title: 

Astragaloside IV inhibits excessive mesangial cell proliferation and renal fibrosis caused by diabetic nephropathy via modulation of the TGF-β1/Smad/miR-192 signaling pathway.

Abstract: 

Astragaloside IV (ASI) exhibits a wide variety of pharmacological effects in cardiovascular diseases, hepatitis and kidney disease and due to this, ASI has recently become an attractive research target. The present study aimed to determine the effect of ASI on renal fibrosis and the mechanisms underlying its therapeutic effects in diabetic nephropathy (DN)., ASI was added to rat mesangial cells (RMCs) and cultured with a high level of glucose (HG) to observe the effects exhibited on proliferation and fibrosis-related mRNA and protein expression., a DN model was established using streptozotocin administration in rats, and renal injury was evaluated using renal histological examination. The expression levels of related mRNAs and proteins were analyzed using reverse transcription-quantitative PCR, western blot analysis and immunohistochemistry. ASI was demonstrated to downregulate miR-192 expression and inhibit excessive proliferation of RMCs, which was induced by HG, in a dose-dependent manner. Additionally, ASI exhibited a therapeutic effect on DN rats. ASI was also demonstrated to decrease the miR-192 expression and mRNA and protein expression of transforming growth factor-β1 (TGF-β1), Smad3, α-smooth muscle actin (α-SMA) and collagen type 1 (col1), and increase the mRNA and protein expression of Smad7and. These results suggested that ASI exhibited a therapeutic effect on DN, possibly due to the inhibition of excessive mesangial proliferation and renal fibrosis via the TGF-β1/Smad/miR-192 signaling pathway.

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PMID: 

Exp Ther Med. 2019 Oct ;18(4):2877-2884. Epub 2019 Aug 16. PMID: 31572532

Abstract Title: 

Astragaloside IV alleviates the symptoms of experimental ulcerative colitisand.

Abstract: 

Ulcerative colitis (UC) is a chronic and relapsing inflammatory intestinal disease. Although the morbidity of UC has increased notably in recent years, effective therapeutic treatment remains unsatisfactory. Astragaloside IV (ASI), a monomeric compound isolated from the traditional Chinese medicine herb, exhibits anti-inflammatory effects. The present study aimed to investigate the therapeutic effects of ASI on experimental UCand. Cell proliferation was detected via a Cell Counting Kit-8 assay. In addition, the concentrations of the inflammatory factors myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and nitric oxide (NO) in the colon tissues were determined by ELISA. Western blot analysis was used to examine phosphorylated transcription factor p65 (p-p65), p-inhibitor of NF-κB (IκB), claudin-1 and tight junction protein ZO-1 (ZO-1) protein levelsand, respectively. The results indicated that lipopolysaccharide (LPS) significantly increased the pro-inflammatory cytokines TNF-α, IL-1β and IL-6 in CCD-18Co cells, which was markedly ameliorated by ASI. In addition to the inhibition of pro-inflammatory cytokines, ASI decreased the levels of p-p65 and p-IκB proteins. In addition, ASI decreased the disease activity index scores, and increased colon lengths in dextran sulfate sodium-induced UC mice. ASI also decreased the levels of the pro-inflammatory factors MPO, TNF-α, IL-1β, IL-6 and NO, and upregulated the expression of claudin-1 and ZO-1 in colon tissues. Therefore, ASI was effective in ameliorating experimental UCandvia the inhibition of inflammatory molecules, and the downregulation of NF-κB signaling. In conclusion, ASI may serve as a potential therapeutic agent for the treatment of UC.

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PMID: 

Hepatol Res. 2014 Jun ;44(6):663-677. Epub 2013 Jun 18. PMID: 23682614

Abstract Title: 

Effects of oral intake of hydrogen water on liver fibrogenesis in mice.

Abstract: 

AIM: Liver fibrosis is the universal consequence of chronic liver diseases. Sustained hepatocyte injury initiates an inflammatory response, thereby activating hepatic stellate cells, the principal fibrogenic cells in the liver. Reactive oxygen species are involved in liver injury and are a promising target for treating liver fibrosis. Hydrogen water is reported to have potential as a therapeutic tool for reactive oxygen species-associated disorders. This study aimed to investigate the effects of hydrogen water on liver fibrogenesis and the mechanisms underlying these effects.METHODS: C57BL/6 mice were fed with hydrogen water or control water, and subjected to carbon tetrachloride, thioacetamide and bile duct ligation treatments to induce liver fibrosis. Hepatocytes and hepatic stellate cells were isolated from mice and cultured with or without hydrogen to test the effects of hydrogen on reactive oxygen species-induced hepatocyte injuries or hepatic stellate cell activation.RESULTS: Oral intake of hydrogen water significantly suppressed liver fibrogenesis in the carbon tetrachloride and thioacetamide models, but these effects were not seen in the bile duct ligation model. Treatment of isolated hepatocyte with 1 μg/mL antimycin A generated hydroxyl radicals. Culturing in the hydrogen-rich medium selectively suppressed the generation of hydroxyl radicals in hepatocytes and significantly suppressed hepatocyte death induced by antimycin A; however, it did not suppress hepatic stellate cell activation.CONCLUSION: We conclude that hydrogen water protects hepatocytes from injury by scavenging hydroxyl radicals and thereby suppresses liver fibrogenesis in mice.

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PMID: 

Clin Transl Sci. 2013 Oct ;6(5):372-5. Epub 2013 Jun 13. PMID: 24127924

Abstract Title: 

Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B.

Abstract: 

OBJECTIVE: To investigate effects of hydrogen-rich water (HRW) on oxidative stress, liver function and HBV DNA in patients with chronic hepatitis B (CHB).METHODS: Sixty patients with CHB were randomly assigned into routine treatment group or hydrogen treatment group in which patients received routine treatment alone or additional oral HRW (1200-1800 mL/day, twice daily), respectively, for 6 consecutive weeks. Serum oxidative stress, liver function, and HBV DNA level were detected before and after treatment. Thirty healthy subjects served as controls.RESULTS: When compared with controls, oxidative stress was obvious in CHB patients, and the liver function also significantly impaired. After treatment, the oxidative stress remained unchanged in routine treatment group, but markedly improved in hydrogen treatment group. The liver function was improved significantly and the HBV DNA reduced markedly after corresponding treatments. Although a significant difference was noted in the oxidative stress between two groups after treatment, the liver function and HBV DNA level were comparable after treatment and both had improved tendencies.CONCLUSION: HRW significantly attenuates oxidative stress in CHB patients, but further study with long-term treatment is required to confirm the effect of HRW on liver function and HBV DNA level.

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PMID: 

J Microbiol Biotechnol. 2017 Feb 28 ;27(2):365-371. PMID: 27780950

Abstract Title: 

Hydrogen Treatment Protects against Cell Death and Senescence Induced by Oxidative Damage.

Abstract: 

Hydrogen has potential for preventive and therapeutic applications as an antioxidant. However, micro- and macroparticles of hydrogen in water disappear easily over time. In order to eliminate reactive oxygen species (ROS) related with the aging process, we used functional water containing nanoparticle hydrogen. Nanoparticle hydrogen does not disappear easily and collapse under water after long periods of time. We used murine embryonic fibroblasts that were isolated from 12.5-day embryos of C57BL/6 mice. We investigated the ability of nanoparticle hydrogen in water to suppress hydroxyurea-induced ROS production, cytotoxicity, and the accumulation ofβ-galactosidase (an indicator of aging), and promote cell proliferation. The accumulation of β-galactosidase in the cytoplasm and the appearance of abnormal nuclei were inhibited by daily treatment of cells with hydrogen water. When the aging process was accelerated by hydroxyurea-induced oxidative stress, the effect of hydrogen water was even more remarkable. Thus, this study showed the antioxidant and anti-senescence effects of hydrogen water. Nanoparticle hydrogen water is potentially a potent anti-aging agent.

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PMID: 

Med Gas Res. 2016 Jul-Sep;6(3):177-179. Epub 2016 Oct 14. PMID: 27867488

Abstract Title: 

Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease.

Abstract: 

The incidence of chronic graft-versus-host-disease is rising year by year, which has become the leading cause of non-transplantation related death and has become the most difficult complication of allogeneic hematopoietic stem cell transplantation to deal with. Inflammation and fibrosis play dominant roles in the pathogenesis of chronic graft-versus-host-disease. Studies have shown that molecular hydrogen has anti-inflammatory, antioxidant, anti-fibrosis effects. Therefore, we hypothesized that molecular hydrogen may have therapeutic effects on chronic graft-versus-host-disease. Here, we report a patient with severe chronic graft-versus-host-disease successfully treated by drinking hydrogen rich water which may be a safe and effective method for chronic graft-versus-host-disease.

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PMID: 

Oxid Med Cell Longev. 2017 ;2017:8241678. Epub 2017 Jan 22. PMID: 28243358

Abstract Title: 

Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical.

Abstract: 

We examined whether consumption of hydrogen-rich water (HW) could ameliorate hematopoietic stem cell (HSC) injury in mice with total body irradiation (TBI). The results indicated that HW alleviated TBI-induced HSC injury with respect to cell number alteration and to the self-renewal and differentiation of HSCs. HW specifically decreased hydroxyl radical (OH) levels in the c-kitcells of 4 Gy irradiated mice. Proliferative bone marrow cells (BMCs) increased and apoptotic c-kitcells decreased in irradiated mice uptaken with HW. In addition, the mean fluorescence intensity (MFI) of-H2AX and percentage of 8-oxoguanine positive cells significantly decreased in HW-treated c-kitcells, indicating that HW can alleviate TBI-induced DNA damage and oxidative DNA damage in c-kitcells. Finally, the cell cycle (P21), cell apoptosis (BCL-XL and BAK), and oxidative stress (NRF2, HO-1, NQO1, SOD, and GPX1) proteins were significantly altered by HW in irradiated mouse c-kitcells. Collectively, the present results suggest that HW protects against TBI-induced HSC injury.

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PMID: 

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 Mar ;29(3):260-264. PMID: 28627348

Abstract Title: 

[Effect of hydrogen-rich water on the CD34 expression in lesion boundary brain tissue of rats with traumatic brain injury].

Abstract: 

OBJECTIVE: To observe the effect of hydrogen-rich water on the CD34 expression and angiogenesis in lesion boundary brain tissue of rats with traumatic brain injury (TBI).METHODS: A total of 54 adult male Sprague-Dawley (SD) rats were divided into three groups by random number table: namely sham-operated group (sham group), trauma group (TBI group), and trauma + hydrogen-rich water group (TBI+HW group), the rats in each group were subdivided into 1, 3 and 7 days subgroups according to the time points after trauma, with 6 rats in each subgroup. The TBI model was reproduced by using a modified Feency method for free fall impact, and the rats in sham group were not given brain impact after craniotomy. The rats in TBI+HW group were given intraperitoneal injection of hydrogen-rich water (5 mL/kg) after TBI model reproduction, and then once a day until being sacrificed, and the rats in sham group and TBI group were given the same amount of normal saline. The neurological severity scores (NSS) for neurologic deficits were calculated at corresponding time points, and then the rats were sacrificed for brain tissue at 3 mm around lesion boundary. After hematoxylin-eosin (HE) staining, the pathological changes in lesion boundary brain tissue were observed under light microscope. The expression of CD34cells was observed by immunohistochemical analysis, which markers were used to count the newborn blood capillary sprouts around the traumatic brain tissue. The protein expression of CD34 was determined by Western Blot.RESULTS: NSS scores at all time points in sham group were 0. NSS scores in TBI and TBI+HW groups showed a decreased tendency with time prolongation after TBI, which showed more significant in TBI+HW group, NSS scores at 3 days and 7 days were significantly lower than those of TBI group (3 day: 8.67±0.52 vs. 11.56±1.94, 7 days: 7.33±0.52 vs. 8.17±0.98, both P

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