PMID: Life Sci. 2019 Feb 15 ;219:257-263. Epub 2018 Nov 23. PMID: 30472298 Abstract Title: Carvacrol ameliorates experimental autoimmune encephalomyelitis through modulating pro- and anti-inflammatory cytokines. Abstract: AIM: The inflammatory process is a key step in multiple sclerosis (MS) development. Carvacrol exhibits various anti-inflammatory properties. We aimed to assess the Carvacrol effects on clinical manifestations …
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Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes.
PMID: J Cell Biochem. 2018 Nov 28. Epub 2018 Nov 28. PMID: 30485517 Abstract Title: Carvacrol suppresses inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes. Abstract: BACKGROUND: Fibroblast-like synoviocytes (FLSs) play an essential role in the chronic inflammatory process of rheumatoid arthritis (RA). Carvacrol is a natural monoterpenic phenol that retains significant anti-inflammatory activity. However, the …
Carvacrol attenuates hippocampal neuronal death after global cerebral ischemia.
PMID: Cells. 2018 Nov 26 ;7(12). Epub 2018 Nov 26. PMID: 30486272 Abstract Title: Carvacrol Attenuates Hippocampal Neuronal Death after Global Cerebral Ischemia via Inhibition of Transient Receptor Potential Melastatin 7. Abstract: Over the last two decades, evidence supporting the concept of zinc-induced neuronal death has been introduced, and several intervention strategies have been investigated. …
Continue reading “Carvacrol attenuates hippocampal neuronal death after global cerebral ischemia.”
The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats.
PMID: Biomed Pharmacother. 2019 Mar ;111:568-578. Epub 2018 Dec 29. PMID: 30597310 Abstract Title: The ameliorative effect of carvacrol on oxidative stress and germ cell apoptosis in testicular tissue of adult diabetic rats. Abstract: BACKGROUND: Diabetes is one of the most chronic and widespread diseases causing the damages to the male reproductive system. Nowadays, several …
Carvacrol suppresses the progression of liver fibrosis.
PMID: Immunopharmacol Immunotoxicol. 2019 Feb ;41(1):163-171. Epub 2019 Feb 1. PMID: 30706740 Abstract Title: Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl)-induced liver fibrosis in rats. Abstract: Little is known about the exact underlying molecular mechanisms of the hepatoprotective effect of carvacrol against liver …
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This analysis of plasma donors indicates that the measles vaccine has become increasingly ineffective.
PMID: J Infect Dis. 2017 11 15 ;216(8):977-980. PMID: 28968738 Abstract Title: Measles Virus Neutralizing Antibodies in Intravenous Immunoglobulins: Is an Increase by Revaccination of Plasma Donors Possible? Abstract: We report a screen of plasma donors confirming that widespread use of childhood measles vaccination since 1963 resulted in a decrease in average measles virus antibody …
Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1/2 and NF-kB pathway.
PMID: Int Immunopharmacol. 2019 Jul 26 ;75:105743. Epub 2019 Jul 26. PMID: 31357087 Abstract Title: Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1/2 and NF-kB pathway. Abstract: Macrophages are immune system cells that respond to various pathogenic insults. The recognition of antigens is performed through receptors such as TLR4 and RAGE, which …
Carvacrol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro models of Parkinson’s disease.
PMID: Neurotox Res. 2019 Jul 30. Epub 2019 Jul 30. PMID: 31364033 Abstract Title: Carvacrol Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in In Vivo and In Vitro Models of Parkinson's Disease. Abstract: Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons that project from the substantia nigra pars compacta to …
Carvacrol induced program cell death and cell cycle arrest in androgen-independent human prostate cancer cells.
PMID: Anticancer Agents Med Chem. 2019 Jul 31. Epub 2019 Jul 31. PMID: 31364516 Abstract Title: Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Abstract: BACKGROUND: Several studies have revealed that abnormal activation of Notch signaling is closely related with the development and …
The combination of carvacrol and exercise could be an effective therapeutic tool for treatment of neurobehavioral deficits in Parkinson’s disease patients.
PMID: Arq Neuropsiquiatr. 2019 Jul 29 ;77(7):493-500. Epub 2019 Jul 29. PMID: 31365641 Abstract Title: Effects of carvacrol and physical exercise on motor and memory impairments associated with Parkinson's disease. Abstract: The present study was undertaken to investigate the effects of carvacrol and treadmill exercise on memory deficit, rotational behavior and oxidative stress biomarkers in …
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