Blood-brain barrier permeability study of ginger constituents.

PMID:  J Pharm Biomed Anal. 2019 Aug 19 ;177:112820. Epub 2019 Aug 19. PMID: 31476432 Abstract Title:  Blood-brain barrier permeability study of ginger constituents. Abstract:  Ginger, the rhizome of Zingiber officinale Roscoe is of great importance in the traditional medicine for the treatment of various diseases. More than 400 constituents have been reported in the …

Shogaol could be better than the conventional immunosuppressive chemotherapeutic remedy 6-TG in treatment of DSS-induced ulcerative colitis.

PMID:  Anal Cell Pathol (Amst). 2019 ;2019:5134156. Epub 2019 Mar 6. PMID: 30963020 Abstract Title:  Effect of Shogaol on the Expression of Intestinal Stem Cell Markers in Experimentally Induced Colitis in BALB/c Mice. Abstract:  Aim: This study is aimed at investigating the effect of Shogaol, a phenolic constituent of ginger, on dextran sodium sulfate- (DSS-) …

6-shogaol prevents UVB radiation mediated inflammation and oxidative stress through modulating NrF2 signalling in human epidermal keratinocytes.

PMID:  J Photochem Photobiol B. 2019 Aug ;197:111518. Epub 2019 May 31. PMID: 31202076 Abstract Title:  6-shogaol, a active constiuents of ginger prevents UVB radiation mediated inflammation and oxidative stress through modulating NrF2 signaling in human epidermal keratinocytes (HaCaT cells). Abstract:  Disclosure of ultraviolet (UV) radiation is the key feature from environment to cause redness …

6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways.

PMID:  Am J Physiol Renal Physiol. 2019 Jul 17. Epub 2019 Jul 17. PMID: 31313953 Abstract Title:  6-Shogaol protects against ischemic acute kidney injury by modulating NFκB and heme oxygenase-1 pathways. Abstract:  Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem without effective therapy. Ginger is one of the …

Ginger extracts could have a potent protective effects against nephrotoxicity induced by various toxicants.

PMID:  Saudi J Biol Sci. 2019 Feb ;26(2):382-389. Epub 2017 Aug 18. PMID: 31485182 Abstract Title:  Biological activities of ginger against cadmium-induced renal toxicity. Abstract:  Our aim was to evaluate the protective and antioxidant effects of ginger extract against cadmium-induced renal toxicity in animal models and to support the use of ginger as anti-renal failure …

This case study describes a case of measles that was genotyped as being caused by the vaccine strain. The symptoms developed 37 day post-vaccination which exceeds the normal incubation period of 8-12 days for wild-type measles.

PMID:  Euro Surveill. 2013 Dec 5 ;18(49). Epub 2013 Dec 5. PMID: 24330942 Abstract Title:  Case of vaccine-associated measles five weeks post-immunisation, British Columbia, Canada, October 2013. Abstract:  We describe a case of vaccine-associated measles in a two-year-old patient from British Columbia, Canada, in October 2013, who received her first dose of measles-containing vaccine 37 …

Curcumin ameliorates the targeted delivery of methotrexate intercalated montmorillonite clay to cancer cells.

PMID:  Eur J Pharm Sci. 2019 Jul 1 ;135:91-102. Epub 2019 May 9. PMID: 31078644 Abstract Title:  Curcumin ameliorates the targeted delivery of methotrexate intercalated montmorillonite clay to cancer cells. Abstract:  Montmorillonite Clay (MMT) is aimed to develop as an orally administrable drug delivery vehicle with enhanced efficacy. Aiming to enhance the therapeutic index of …

Nanoalumina stimulates mitochondrial dysfunction, leading to overactive autophagic degradation and results in apoptosis. This was confirmed by upregulation of apoptotic genes in the brains of nanoalumina-treated mice.

PMID:  Nanomedicine. 2013 Feb ;9(2):212-21. Epub 2012 Jun 9. PMID: 22687898 Abstract Title:  Autophagy is involved in nanoalumina-induced cerebrovascular toxicity. Abstract:  UNLABELLED: The current study focused on blood-brain barrier disruption and neurovascular damage induced by engineered nanomaterials. Exposure to nanoalumina, but not to nanocarbon, induced a dose-dependent mitochondrial potential collapse, increased autophagy of brain endothelial …

Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects.

PMID:  Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30:109757. Epub 2019 Aug 30. PMID: 31476335 Abstract Title:  Ascorbic acid presents rapid behavioral and hippocampal synaptic plasticity effects. Abstract:  Growing evidence has suggested that ascorbic acid may exhibit rapid anxiolytic and antidepressant-like effects. In this study the effects of a single administration of ascorbic acid (1 mg/kg, p.o.), …

Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats.

PMID:  Braz J Med Biol Res. 2019 ;52(9):e8290. Epub 2019 Sep 2. PMID: 31482998 Abstract Title:  Local treatment with ascorbic acid accelerates recovery of post-sutured Achilles tendon in male Wistar rats. Abstract:  Tendon rupture is a very frequent accident involving average people and high-performance athletes. Clinical studies describe tendon recovery as a painful and slow …

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