PMID: J Ethnopharmacol. 2018 Jan 10 ;210:1-9. Epub 2017 Jul 4. PMID: 28684297 Abstract Title: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3β/cyclin D1 pathway. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma kwangsiensis S. G. Lee&C. F. Liang (Guangxi ezhu, in Chinese) belongs to the Zingiberaceae family, has been used …
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Low cytochrome C oxidase is associated with Alzheimer’s disease. This in vivo animal study indicates that certain heavy metals may induce oxidative stress and downregulate cytochrome C oxidase activity.
PMID: J Mol Neurosci. 2011 Mar ;43(3):284-9. Epub 2010 Aug 20. PMID: 20725867 Abstract Title: Unraveling the role of metal ions and low catalytic activity of cytochrome C oxidase in Alzheimer's disease. Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by high levels of aluminum and certain other metal ions in the brain: The …
Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1.
PMID: Oncol Rep. 2017 Dec ;38(6):3583-3591. Epub 2017 Oct 12. PMID: 29039582 Abstract Title: Curcumol inhibits the proliferation of gastric adenocarcinoma MGC-803 cells via downregulation of IDH1. Abstract: Curcumol, a polyphenol compound derived from the rhizome of Curcuma, has been established as an antitumor compound against multiple types of cancer, including gastric (GC), lung, liver and …
Curcumol demonstrated potential antitumor activities in MG-63 cells and may be used as a novel effective reagent in the treatment of osteosarcoma.
PMID: Oncol Lett. 2017 Dec ;14(6):6387-6394. Epub 2017 Sep 21. PMID: 29151904 Abstract Title: Inhibition of autophagy attenuated curcumol-induced apoptosis in MG-63 human osteosarcoma cells via Janus kinase signaling pathway. Abstract: The present study aimed to investigate whether autophagy was triggered by curcumol and to explore the association between autophagy and apoptosis of MG-63 cells …
Curcumol controls choriocarcinoma stem-like cells self-renewal.
PMID: Med Sci Monit. 2018 Jan 24 ;24:461-472. Epub 2018 Jan 24. PMID: 29363667 Abstract Title: Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation. Abstract: BACKGROUND Cancer stem cells (CSCs), in choriocarcinoma and other carcinomas, possess the ability of self-renewal and multilineage differentiation potential. We …
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Bras Cause More than Breast Cancer: Preliminary Results of the International Bra-Free Study
We encourage women everywhere to join the International Bra-Free Study and see for themselves, on themselves, how chronic health problems that plagued them for years could be related to their bras
These results suggest that green tea can ameliorate hyperglycemia in diabetic rodents by stimulating GLUT4-mediated glucose uptake.
PMID: Int J Mol Sci. 2019 May 16 ;20(10). Epub 2019 May 16. PMID: 31100973 Abstract Title: Green Tea Ameliorates Hyperglycemia by Promoting the Translocation of Glucose Transporter 4 in the Skeletal Muscle of Diabetic Rodents. Abstract: It is known that green tea helps prevent obesity and diabetes mellitus. In this study, we aimed to …
Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer.
PMID: Oncotarget. 2017 Dec 29 ;8(70):115526-115545. Epub 2017 Dec 14. PMID: 29383179 Abstract Title: Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer. Abstract: Combinatorial therapies that target multiple signaling pathways may provide improved therapeutic responses over monotherapies. Celecoxib and curcumol are two highly hydrophobic drugs which show bioavailability problems due …
Curcumol exerts anticancer effect in cholangiocarcinoma cells.
PMID: Front Physiol. 2018 ;9:234. Epub 2018 Mar 20. PMID: 29615928 Abstract Title: Curcumol Exerts Anticancer Effect in Cholangiocarcinoma Cells via Down-Regulating CDKL3. Abstract: Curcumol is the major component extracted from root of. Recent studies have shown that curcumol exerts therapeutic effects against multiple conditions, particularly cancers. However, the therapeutic role and mechanism of curcumol …
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Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1.
PMID: Mol Med Rep. 2018 Jun ;17(6):7513-7520. Epub 2018 Mar 28. PMID: 29620189 Abstract Title: Curcumol attenuates epithelial-mesenchymal transition of nasopharyngeal carcinoma cells via TGF-β1. Abstract: The current study aimed to identify the effect and primary mechanism of Curcumol on the migration of nasopharyngeal carcinoma (NPC) cells in vitro and in vivo. Curcumol was dissolved in absolute …
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