PMID: Nutrients. 2019 Aug 22 ;11(9). Epub 2019 Aug 22. PMID: 31443565 Abstract Title: Bitter Orange (Citrus aurantium Linné) Improves Obesity by Regulating Adipogenesis and Thermogenesis through AMPK Activation. Abstract: Obesity is a global health threat. Herein, we evaluated the underlying mechanism of anti-obese features of bitter orange (Linné, CA). Eight-week-administration of CA in high …
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The anticancer efficiency of Citrullus colocynthis toward the colorectal cancer therapy.
PMID: J Gastrointest Cancer. 2019 Aug 29. Epub 2019 Aug 29. PMID: 31463888 Abstract Title: The Anticancer Efficiency of Citrullus colocynthis Toward the Colorectal Cancer Therapy. Abstract: BACKGROUND: Colorectal cancer (CRC) remains a major cause of death worldwide. Chemotherapy is associated with some side effects during CRC treatment. Hence, proper employment of lower toxic and …
Orientin could be a potent chemotherapeutic agent against colorectal cancer.
PMID: Biomolecules. 2019 Aug 27 ;9(9). Epub 2019 Aug 27. PMID: 31461995 Abstract Title: Orientin Induces G0/G1 Cell Cycle Arrest and Mitochondria Mediated Intrinsic Apoptosis in Human Colorectal Carcinoma HT29 Cells. Abstract: Colorectal carcinoma is one of the utmost diagnosed cancer with a steep increase in mortality rate. The incidence has been increasing in developing …
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Freeze-dried fruit powder of Actinidia arguta ameliorates dextran sulphate sodium-induced ulcerative colitis.
PMID: Food Funct. 2019 Aug 27. Epub 2019 Aug 27. PMID: 31454000 Abstract Title: The dietary freeze-dried fruit powder of Actinidia arguta ameliorates dextran sulphate sodium-induced ulcerative colitis in mice by inhibiting the activation of MAPKs. Abstract: In this study, we aimed at investigating the antiinflammatory activity of the freeze-dried fruit powder of Actinidia arguta …
Naringenin appears to have potential in the treatment of sepsis.
PMID: Med Sci Monit. 2019 Aug 11 ;25:5986-5991. Epub 2019 Aug 11. PMID: 31401645 Abstract Title: Protective Effects of Naringenin in a Rat Model of Sepsis-Triggered Acute Kidney Injury via Activation of Antioxidant Enzymes and Reduction in Urinary Angiotensinogen. Abstract: BACKGROUND Sepsis is a devastating medical condition. In the USA, about 745 000 people are …
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Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity.
PMID: Eur J Pharmacol. 2019 Aug 15 ;857:172456. Epub 2019 Jun 17. PMID: 31220438 Abstract Title: Flavonoids from Citrus aurantium ameliorate TNBS-induced ulcerative colitis through protecting colonic mucus layer integrity. Abstract: Intestinal barrier injury is recognized as the main reason for ulcerative colitis (UC) which is a chronic inflammatory disease and the effective therapeutic methods …
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.
PMID: Nat Commun. 2019 Aug 28 ;10(1):3923. Epub 2019 Aug 28. PMID: 31462679 Abstract Title: Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge. Abstract: Circadian disruption aggravates age-related decline and mortality. However, it remains unclear whether circadian enhancement can retard aging in mammals. We previously reported that the small …
Saffron and its can be effective in preventing and treating diseases caused by abnormal α-Synuclein aggregation.
PMID: J Nat Med. 2018 Jan ;72(1):274-279. Epub 2017 Nov 17. PMID: 29147836 Abstract Title: Effects of saffron and its constituents, crocin-1, crocin-2, and crocetin on α-synuclein fibrils. Abstract: Saffron, the stigma of Crocus sativus Linné (Iridaceae family), has been known to inhibit aggregation of β-amyloid, a nerve tissue protein. α-Synuclein (αS) is a 140-amino acid protein …
Crocin and picrocrocin could be a promising anti-HSV and anti-HIV agent for herbal therapy against viral infections.
PMID: Curr Drug Deliv. 2018 ;15(5):698-704. PMID: 29189153 Abstract Title: Antiviral Effects of Saffron and its Major Ingredients. Abstract: BACKGROUND: The lack of an effective vaccine against viral infections, toxicity of the synthetic anti-viral drugs and the generation of resistant viral strains led to discover novel inhibitors. Recently, saffron and its compounds were used to …
Crocin elicited marked anti-metastatic potential by regulating the metastasis induced biomarkers.
PMID: J Biomed Res. 2017 11 1. Epub 2017 Nov 1. PMID: 29219852 Abstract Title: Dietary Crocin Reverses Melanoma Metastasis. Abstract: Crocus sativus and its bioactive constituent crocin are well known for anti-tumor potential in different models. However, the efficacy of crocin on in-vivo melanoma metastasis is not yet reported. In this study, melanoma metastatic …
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