PMID: Int Immunopharmacol. 2018 Feb ;55:120-127. Epub 2017 Dec 22. PMID: 29248792 Abstract Title: Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization. Abstract: Atherosclerosis is a chronic inflammatory disease arising from an imbalance in lipid levels and the accumulation of cholesterol-laden macrophages in the artery wall. Crocin is an active …
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Saffron is a safe and effective treatment in improving hot flashes and depressive symptoms in post-menopausal healthy women.
PMID: Arch Gynecol Obstet. 2018 03 ;297(3):717-724. Epub 2018 Jan 13. PMID: 29332222 Abstract Title: Efficacy of Crocus sativus (saffron) in treatment of major depressive disorder associated with post-menopausal hot flashes: a double-blind, randomized, placebo-controlled trial. Abstract: PURPOSE: Due to concerns regarding the side effects of hormone therapy, many studies have focused on the development …
Administration of crocin reduced d-galactose-induced aging.
PMID: Avicenna J Phytomed. 2018 Jan-Feb;8(1):14-23. PMID: 29387570 Abstract Title: Protective effect of crocin against d-galactose-induced aging in mice. Abstract: Objective: Aging is a multifactorial phenomenon, which attribute to different diseases and abnormalities in living systems. Oxidative stress, which is an important factor in aging, exacerbates this process via different mechanisms. Crocin (CR), one of …
Continue reading “Administration of crocin reduced d-galactose-induced aging.”
Saffron has beneficial effects on depression and homocysteine level in patients with major depression.
PMID: Avicenna J Phytomed. 2018 Jan-Feb;8(1):43-50. PMID: 29387573 Abstract Title: Saffron improved depression and reduced homocysteine level in patients with major depression: A Randomized, double-blind study. Abstract: Objectives: A correlation between hyperhomocysteinemia, and depression has been reported. Saffron () is recommended for treatment of depression; hence, in this study the effect of co-administration of saffron …
Protective effects of berberine against exhaustion exercise induced myocardial injury.
PMID: Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Aug 24 ;47(8):647-652. PMID: 31434437 Abstract Title: [Protective effects of berberine against exhaustion exercise induced myocardial injury in rats]. Abstract: To investigate the effect and possible mechanism of berberine (Ber) on myocardial injury induced by exhaustion exercise (Ee).Forty healthy male SPF Sprague-Dawley rats were randomly divided …
An insight into the molecular mechanism of berberine towards multiple cancer types through systems pharmacology.
PMID: Front Pharmacol. 2019 ;10:857. Epub 2019 Aug 6. PMID: 31447670 Abstract Title: An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology. Abstract: Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), …
Berberine inhibits the growth of human rhabdomyosarcoma cells.
PMID: Biosci Biotechnol Biochem. 2019 Aug 29:1-13. Epub 2019 Aug 29. PMID: 31462179 Abstract Title: Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells. Abstract: A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cellsinducing cell cycle arrest. However, it has not been investigated whether berberine and its …
Continue reading “Berberine inhibits the growth of human rhabdomyosarcoma cells.”
This study reveals that crocin improves myocardial infarction-induced impairments in cardiac function.
PMID: Int Heart J. 2018 Mar 30 ;59(2):387-393. Epub 2018 Feb 23. PMID: 29479012 Abstract Title: Crocin Attenuates Oxidative Stress and Myocardial Infarction Injury in Rats. Abstract: Oxidative stress and excessive nitric oxide (NO) production play considerable roles in infarction-induced injury impairing cardiac functions. Crocin is the active constituent of Crocus sativus (saffron) with antioxidant …
Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system.
PMID: Biomed Pharmacother. 2018 May ;101:174-180. Epub 2018 Feb 24. PMID: 29486335 Abstract Title: Crocin attenuates cyclophosphamide induced testicular toxicity by preserving glutathione redox system. Abstract: Chemotherapy induced testicular toxicity is an emerging reason for azoospermia and impotency in males. Cyclophosphamide (CP) is a widely used chemotherapeutic agent to manage neoplastic and non-neoplastic autoimmune diseases. …
Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells.
PMID: Microvasc Res. 2018 07 ;118:82-89. Epub 2018 Mar 7. PMID: 29524452 Abstract Title: Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells. Abstract: In this study, we investigated the role of mitogen-activated protein kinase (MAPK) signaling pathways in mediation of the protective effects of saffron extract, saffron …
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