PMID: J Affect Disord. 2018 05 ;232:349-357. Epub 2018 Feb 26. PMID: 29510352 Abstract Title: affron, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study. Abstract: BACKGROUND: Saffron has antidepressant and anxiolytic effects in adults with mild-to-moderate depression. However, this is the …
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Saffron hydroalcoholic extract may improve blood glucose control by reducing fasting blood sugar in T2D patients.
PMID: J Res Med Sci. 2018 ;23:16. Epub 2018 Feb 20. PMID: 29531568 Abstract Title: The effect of saffron (L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trial. Abstract: Background: Metabolic control is a major concern in preventing diabetic complications. Saffron as a natural source of antioxidants could …
Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice.
PMID: Saudi J Biol Sci. 2018 May ;25(4):747-754. Epub 2016 Oct 13. PMID: 29740240 Abstract Title: Antifibrotic effects of crocin on thioacetamide-induced liver fibrosis in mice. Abstract: Liver fibrosis is a major health concern that results in significant morbidity and mortality. Up-to-date, there is no standard treatment for fibrosis because of its complex pathogenesis. Crocin …
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Saffron was effective in the treatment of major depressive disorder and had comparable efficacy to synthetic antidepressants.
PMID: Neuropsychiatr Dis Treat. 2018 ;14:1297-1305. Epub 2018 May 21. PMID: 29849461 Abstract Title: Comparative efficacy and safety ofL. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials. Abstract: Purpose: To investigate the efficacy and safety of saffron in the treatment of major depressive disorder (MDD) in comparison …
Saffron could be used for the treatment in diabetes.
PMID: Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Feb 8 ;34(2):173-176. PMID: 29926685 Abstract Title: [Effect of saffron aqueous extract on the level of blood glucose in experimental diabetes mice]. Abstract: OBJECTIVES: To investigate the effects of saffron aqueous extract (SE) on blood glucose, lipid and pancreatic tissue in streptozocin-induced diabetes mice.METHODS: Diabetes …
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Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro.
PMID: Phytomedicine. 2009 Aug ;16(8):694-702. Epub 2009 Apr 24. PMID: 19394208 Abstract Title: Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro. Abstract: Carthamus tinctorius L. (safflower) is one of the most commonly used Chinese herbal medicines to prevent and treat cardiac disease in clinical practice. However, the mechanisms responsible …
C. tinctorius flower can act as a biological antioxidant in a cell culture experimental model and protect osteoblasts from oxidative stress-induced toxicity.
PMID: Phytother Res. 2010 Jul ;24(7):1037-41. PMID: 19960423 Abstract Title: Carthamus tinctorius flower extract prevents H2O2-induced dysfunction and oxidative damage in osteoblastic MC3T3-E1 cells. Abstract: The flowers of Carthamus tinctorius L. (Compositae) have been widely used for enhancing blood circulation and postmenopausal disorder in women. In the present study, the potential protective effects of C. …
Carthamus tinctorius L could potentially serve as a cardio-protective agent against LPS-induced apoptosis.
PMID: J Ethnopharmacol. 2010 Aug 9 ;130(3):505-13. Epub 2010 Jun 9. PMID: 20538053 Abstract Title: Carthamus tinctorius L. prevents LPS-induced TNFalpha signaling activation and cell apoptosis through JNK1/2-NFkappaB pathway inhibition in H9c2 cardiomyoblast cells. Abstract: AIM OF THE STUDY: Severe and potentially fatal hypotension and cardiac contractile dysfunction are common symptoms in patients with sepsis. …
Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction.
PMID: J Ethnopharmacol. 2011 Jan 27 ;133(2):524-30. Epub 2010 Oct 20. PMID: 20969944 Abstract Title: Anti-inflammatory action of methanol extract of Carthamus tinctorius involves in heme oxygenase-1 induction. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The methanol extracts of Carthamus tinctorius (MEC) have long been used in traditional medicine as anti-inflammatory agent, however, the molecular mechanism by which MEC …
Potent α-glucosidase inhibitors from safflower seed.
PMID: Phytother Res. 2012 May ;26(5):722-6. Epub 2011 Oct 24. PMID: 22021176 Abstract Title: Potentα-glucosidase inhibitors from safflower (Carthamus tinctorius L.) seed. Abstract: As part of the search for naturally derivedα-glucosidase inhibitors, the chemical components isolated from safflower seed (Carthamus tinctorius L.) were evaluated. The compounds active as α-glucosidase inhibitors were serotonin derivatives (e.g. N-p-coumaroyl …
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