PMID: Korean J Urol. 2012 Oct ;53(10):705-10. Epub 2012 Oct 19. PMID: 23136631 Abstract Title: Effects of Carthamus tinctorius on Semen Quality and Gonadal Hormone Levels in Partially Sterile Male Rats. Abstract: PURPOSE: Traditional herbal medicine is just one of the many different approaches using plants in the remedy of diseases. Carthamus tinctorius (CT) or …
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These results demonstrated Panax notoginseng, Carthamus tinctorius and their combinations exhibited significant cardio-protective effects.
PMID: J Ethnopharmacol. 2013 Feb 13 ;145(3):722-7. Epub 2012 Dec 10. PMID: 23237935 Abstract Title: Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The decoction of combined Panax notoginseng (Burk) F.H. Chen and Carthamus tinctorius L. has a history of use …
This review demonstrates the pitfalls of various studies attempting to establish the safety of aluminum adjuvants.
PMID: Ann Pharm Fr. 2017 Jul ;75(4):245-256. Epub 2017 May 31. PMID: 28576261 Abstract Title: [Critical analysis of reference studies on aluminium-based adjuvants toxicokinetics]. Abstract: We reviewed the three reference toxicokinetic studies commonly used to suggest innocuity of aluminum (Al)-based adjuvants. A single experimental study was carried out using isotopicAl (Flarend et al., 1997). This …
These results suggested that the hydroalcoholic extract of Carthamus tinctorius possesses beneficial effect on treatment of diabetes.
PMID: J Res Med Sci. 2012 Apr ;17(4):386-92. PMID: 23267403 Abstract Title: Antidiabetic effect of hydroalcoholic extract of Carthamus tinctorius L. in alloxan-induced diabetic rats. Abstract: BACKGROUND: Carthamus tinctorius L. (Compositae) has been used in Iranian traditional medicine for treatment of diabetes. In this study, anti-diabetic effect of its hydroalcoholic extract was compared with that …
There may be an inflammatory component to pathologic pregnancies, as evidenced by a Th1-dominant profile in women whose pregnancies ended in spontaneous abortion.
PMID: Clin Exp Immunol. 1996 Oct ;106(1):127-33. PMID: 8870710 Abstract Title: Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Abstract: Antigen- and mitogen-stimulated cytokine production by peripheral blood mononuclear cells (PBMC) of 50 pregnant women and 31 age- and sex-matched non-pregnant controls were analysed to determine whether …
This study provides additional evidence for a microglial activation component in schizophrenia.
PMID: Behav Brain Res. 2014 Jan 1 ;258:179-86. Epub 2013 Oct 12. PMID: 24129217 Abstract Title: Hypolocomotive behaviour associated with increased microglia in a prenatal immune activation model with relevance to schizophrenia. Abstract: Over the past decade a neurodevelopmental animal model with high validity for schizophrenia has been developed based on the environmental risk factor …
This rat model shows tht individual maternal immune response to maternal immune activation is an important determinant of the behavioral outcome in offspring.
PMID: Brain Behav Immun. 2014 Nov ;42:138-46. Epub 2014 Jun 26. PMID: 24973728 Abstract Title: The risk for behavioural deficits is determined by the maternal immune response to prenatal immune challenge in a neurodevelopmental model. Abstract: BACKGROUND: Schizophrenia is a highly disabling psychiatric disorder with a proposed neurodevelopmental basis. One mechanism through which genetic and …
Protective effects of hydroxysafflor yellow A on β-amyloid-induced neurotoxicity in PC12 cells.
PMID: Neurochem Res. 2013 May ;38(5):951-60. Epub 2013 Feb 19. PMID: 23420419 Abstract Title: Protective effects of hydroxysafflor yellow A onβ-amyloid-induced neurotoxicity in PC12 cells. Abstract: The accumulation of extracellular amyloid-β peptide (Aβ) has been considered as one of the important causes of Alzheimer's disease (AD), the most prevalent form of dementia. Hydroxysafflor yellow A …
Animal studies demonstrate a link between maternal immune activation and autism spectrum disorder in offspring.
PMID: Exp Neurol. 2018 01 ;299(Pt A):241-251. Epub 2017 Jul 8. PMID: 28698032 Abstract Title: Beyond infection – Maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders. Abstract: Immune molecules such as cytokines and chemokines and the cells that produce them within the brain, notably microglia, are critical for normal …
Carthamus red may serve as a candidate with strong a hepatoprotective effect and antioxidant activity in liver damage.
PMID: J Ethnopharmacol. 2013 Jul 9 ;148(2):570-8. Epub 2013 May 14. PMID: 23684718 Abstract Title: Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl(4)-induced liver damage in rats via the Nrf2 pathway. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Carthamus red isolated from safflower (Carthamus tinctorius L., a Chinese traditional medicine) is evaluated for antioxidant …
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