PMID: Environ Toxicol. 2017 Mar ;32(3):754-763. Epub 2016 Apr 20. PMID: 27098997 Abstract Title: Attenuation of the LPS-induced, ERK-mediated upregulation of fibrosis-related factors FGF-2, uPA, MMP-2, and MMP-9 by Carthamus tinctorius L in cardiomyoblasts. Abstract: Severe and potentially fatal hypotension and cardiac contractile dysfunction are common symptoms in patients with sepsis. LPS was previously found …
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Standardized safflower flavonoid extract represents a potential therapeutic herbal treatment for Parkinson’s disease.
PMID: Molecules. 2016 Aug 24 ;21(9). Epub 2016 Aug 24. PMID: 27563865 Abstract Title: Neuroprotective Effects of a Standardized Flavonoid Extract from Safflower against a Rotenone-Induced Rat Model of Parkinson's Disease. Abstract: Parkinson's disease (PD) is a major age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra par compacta (SNpc). …
Cathamus tinctorius represents a potential treatment option for obesity and associated metabolic disorders, including hyperlipidemia.
PMID: Nutr Res. 2016 09 ;36(9):995-1003. Epub 2016 Jul 25. PMID: 27632920 Abstract Title: Defatted safflower seed extract inhibits adipogenesis in 3T3-L1 preadipocytes and improves lipid profiles in C57BL/6J ob/ob mice fed a high-fat diet. Abstract: In the present study, we hypothesized that defatted safflower seed which is known to be rich in polyphenols might …
Safflower yellow should be considered as a potential novel therapeutic agent for the treatment of breast cancer.
PMID: Am J Chin Med. 2016 ;44(7):1491-1506. Epub 2016 Oct 25. PMID: 27776431 Abstract Title: Safflower Yellow Prevents Pulmonary Metastasis of Breast Cancer by Inhibiting Tumor Cell Invadopodia. Abstract: Carthamus tinctorius L. is a traditional Chinese medicine that activates blood circulation and dissipates blood stasis, and has been extensively used as antitumor treatment in a …
Carthamus tinctorius L. ameliorates brain injury followed by cerebral ischemia-reperfusion.
PMID: Iran J Basic Med Sci. 2016 Dec ;19(12):1368-1375. PMID: 28096971 Abstract Title: L. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms. Abstract: OBJECTIVES: L. (CT) or safflower is widely used in traditional Chinese medicine. This study investigated the effects of CT extract (CTE) on ischemia-reperfusion (I/R) brain injury …
Safflower bud inhibits RANKL-induced osteoclast differentiation and prevents bone loss in ovariectomized mice.
PMID: Phytomedicine. 2017 Oct 15 ;34:6-13. Epub 2017 Jul 4. PMID: 28899511 Abstract Title: Safflower bud inhibits RANKL-induced osteoclast differentiation and prevents bone loss in ovariectomized mice. Abstract: BACKGROUND: The powder and extract of safflower seeds are known to be effective in the prevention of bone loss in ovariectomized animals. However, the inhibitory effect and …
Hydroethanolic extract of Carthamus tinctorius induces antidepressant-like effects.
PMID: Iran J Basic Med Sci. 2017 Sep ;20(9):1063-1073. PMID: 29085603 Abstract Title: Hydroethanolic extract ofinduces antidepressant-like effects: modulation by dopaminergic and serotonergic systems in tail suspension test in mice. Abstract: OBJECTIVES: Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is …
Protective effect of safflower seed on cisplatin-induced renal damage.
PMID: Am J Chin Med. 2018 ;46(1):157-174. Epub 2018 Jan 3. PMID: 29298512 Abstract Title: Protective Effect of Safflower Seed on Cisplatin-Induced Renal Damage in Mice via Oxidative Stress and Apoptosis-Mediated Pathways. Abstract: Cisplatin, a platinum chelate with potent antitumor activity against cancers of the testis, ovary, urinary bladder, prostate, and head and neck, has …
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Carthamus tinctorius extract ameliorated hemodynamic alteration and vascular remodelling in 2K-1C hypertensive rats.
PMID: Ann Anat. 2018 Mar ;216:82-89. Epub 2017 Dec 20. PMID: 29274384 Abstract Title: Carthamus tinctorius L. extract improves hemodynamic and vascular alterations in a rat model of renovascular hypertension through Ang II-ATR-NADPH oxidase pathway. Abstract: Carthamus tinctorius L. (CT) is widely used in Asian countries as a beverage and in folk medicine. The effects …
Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma.
PMID: World J Surg Oncol. 2018 Aug 13 ;16(1):167. Epub 2018 Aug 13. PMID: 30103745 Abstract Title: Safflower polysaccharide inhibits the development of tongue squamous cell carcinoma. Abstract: BACKGROUND: Safflower polysaccharide (SPS) is one of the most important active components of safflower (Carthamus tinctorius L.), which has been confirmed to have the immune-regulatory function and …
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