PMID: Environ Toxicol Pharmacol. 2019 Jul 31 ;72:103238. Epub 2019 Jul 31. PMID: 31394428 Abstract Title: A comparative study of the role of crocin and sitagliptin in attenuation of STZ-induced diabetes mellitus and the associated inflammatory and apoptotic changes in pancreaticβ-islets. Abstract: Type 1 diabetes mellitus (T1DM) describes a complex group of metabolic disorders associated …
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Metformin-induced changes of the gut microbiota in healthy young men.
PMID: Diabetologia. 2019 06 ;62(6):1024-1035. Epub 2019 Mar 23. PMID: 30904939 Abstract Title: Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study. Abstract: AIMS/HYPOTHESIS: Individuals with type 2 diabetes have an altered bacterial composition of their gut microbiota compared with non-diabetic individuals. However, these alterations may be …
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Altered microbiome composition in individuals with fibromyalgia.
PMID: Pain. 2019 Jul 2. Epub 2019 Jul 2. PMID: 31219947 Abstract Title: Altered microbiome composition in individuals with fibromyalgia. Abstract: Fibromyalgia (FM) is a prevalent syndrome, characterised by chronic widespread pain, fatigue, and impaired sleep, that is challenging to diagnose and difficult to treat. The microbiomes of 77 women with FM and that of …
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Antiretroviral therapy administration in healthy rhesus macaques is associated with transient shifts in intestinal bacterial diversity.
PMID: J Virol. 2019 Jul 3. Epub 2019 Jul 3. PMID: 31270225 Abstract Title: Antiretroviral therapy administration in healthy rhesus macaques is associated with transient shifts in intestinal bacterial diversity and modest immunological perturbations. Abstract: Gastrointestinal immune system competency is dependent upon interactions with commensal microbiota, which can be influenced by wide-ranging pharmacologic interventions. In …
Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia.
PMID: EBioMedicine. 2019 Aug ;46:499-511. Epub 2019 Jul 18. PMID: 31327695 Abstract Title: Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia. Abstract: BACKGROUND: Fibromyalgia is a complex, relatively unknown disease characterised by chronic, widespread musculoskeletal pain. The gut-brain axis connects the gut microbiome with the brain through the …
A systematic review and meta-analysis of the association between gut microbiota and autism spectrum disorder.
PMID: Front Psychiatry. 2019 ;10:473. Epub 2019 Jul 17. PMID: 31404299 Abstract Title: Association Between Gut Microbiota and Autism Spectrum Disorder: A Systematic Review and Meta-Analysis. Abstract: Autism spectrum disorder (ASD) is characterized by stereotyped behavior and deficits in communication and social interactions. Gastrointestinal (GI) dysfunction is an ASD-associated comorbidity, implying a potential role of …
Emerging roles for the intestinal microbiome in epilepsy.
PMID: Neurobiol Dis. 2019 Aug 21:104576. Epub 2019 Aug 21. PMID: 31445165 Abstract Title: Emerging roles for the intestinal microbiome in epilepsy. Abstract: The gut microbiome is emerging as a key regulator of brain function and behavior and is associated with symptoms of several neurological disorders. There is emerging evidence that alterations in the gut …
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Combined probiotic and dietary intervention is able to improve the gut microbiota composition of human subjects on a high fat diet.
PMID: Exp Ther Med. 2019 Sep ;18(3):2262-2270. Epub 2019 Jul 23. PMID: 31452713 Abstract Title: Supplementation of triple viable probiotics combined with dietary intervention is associated with gut microbial improvement in humans on a high-fat diet. Abstract: Numerous animal studies have demonstrated that oral probiotics may have a beneficial role in preventing obesity, inflammatory bowel …
Safranal has an anti-inflammatory potential and has a strong antioxidative effect.
PMID: An Acad Bras Cienc. 2019 May 23 ;91(2):e20181235. Epub 2019 May 23. PMID: 31141017 Abstract Title: Assessment of Anti-inflammatory and Antioxidant Properties of Safranal on CCI4-Induced Oxidative Stress and Inflammation in Rats. Abstract: The present study aimed to determine the antioxidative and anti-inflammatory effects of safranal on damage induced by CCl4. Experimental animals were …
Safranal attenuates cognitive deficits in amyloid β-induced rat model of Alzheimer’s disease.
PMID: Metab Brain Dis. 2019 Aug 17. Epub 2019 Aug 17. PMID: 31422512 Abstract Title: Safranal, an active ingredient of saffron, attenuates cognitive deficits in amyloidβ-induced rat model of Alzheimer's disease: underlying mechanisms. Abstract: Alzheimer's disease (AD) is the most prevalent neurodegenerative amyloid disorder with progressive deterioration of cognitive and memory skills. Despite many efforts, …
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