PMID: J Pharm Pharmacol. 2019 Jul ;71(7):1162-1171. Epub 2019 May 3. PMID: 31049982 Abstract Title: Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L. Abstract: OBJECTIVES: To explore effective extraction method and to find active constituents, we investigated the biological activity of three extracts and isolated active compounds …
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Demethoxycurcumin: A naturally occurring curcumin analogue for treating non-cancerous diseases.
PMID: J Cell Physiol. 2019 Nov ;234(11):19320-19330. Epub 2019 Apr 4. PMID: 31344992 Abstract Title: Demethoxycurcumin: A naturally occurring curcumin analogue for treating non-cancerous diseases. Abstract: Turmeric extracts contain three primary compounds, which are commonly referred to as curcuminoids. They are curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin. While curcumin has been the most extensively studied of …
Curcumin and tetrahydrocurcumin induce cell death in Ara-C-resistant acute myeloid leukemia.
PMID: Phytother Res. 2019 Apr ;33(4):1199-1207. Epub 2019 Mar 5. PMID: 30834607 Abstract Title: Curcumin and tetrahydrocurcumin induce cell death in Ara-C-resistant acute myeloid leukemia. Abstract: Most anticancer agents induce cancer cell death; however, multidrug-resistant cancers often lead to treatment failure. The effective use of curcumin as an anticancer agent has been demonstrated in clinical …
Tetrahydrocurcumin ameliorates diabetic cardiomyopathy.
PMID: Oxid Med Cell Longev. 2019 ;2019:6746907. Epub 2019 May 9. PMID: 31210844 Abstract Title: Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway. Abstract: Hyperglycemia-induced oxidative stress and fibrosis play a crucial role in the development of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite …
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This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.
PMID: J Cell Biochem. 2019 Sep ;120(9):15989-15996. Epub 2019 Jun 6. PMID: 31168845 Abstract Title: Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial. Abstract: BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) as a prevalent hepatic disease is associated with an increased risk of morbidity and mortality related to the liver and cardiovascular disease …
Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer’s disease.
PMID: J Nutr Biochem. 2019 Aug ;70:147-155. Epub 2019 May 24. PMID: 31207354 Abstract Title: Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease. Abstract: Piperine, the major alkaloid constituent of black pepper, has been reported to possess a wide range of pharmacological effects on the central nervous system, including antidepressant, …
The present study provides useful insight into the apoptotic potential of piperine.
PMID: EXCLI J. 2019 ;18:154-164. Epub 2019 Mar 13. PMID: 31217779 Abstract Title: Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation. Abstract: Piperine (1-piperoylpeperdine), a nitrogenous pungent substance, is present in the fruits of black pepper (Linn.) and long pepper (Linn.). It possesses several pharmacological properties …
Piperine: role in prevention and progression of cancer.
PMID: Mol Biol Rep. 2019 Jul 4. Epub 2019 Jul 4. PMID: 31273611 Abstract Title: Piperine: role in prevention and progression of cancer. Abstract: Cancer is among the leading causes of death worldwide. Several pharmacological protocols have been developed in order to block tumor progression often showing partial efficacy and severe counterproductive effects. It is …
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Thymoquinone may be an important agent for the treatment of sepsis-induced liver injury.
PMID: Exp Ther Med. 2019 Sep ;18(3):1985-1992. Epub 2019 Jul 17. PMID: 31410159 Abstract Title: Protective role of thymoquinone in sepsis-induced liver injury in BALB/c mice. Abstract: Sepsis increases the risk of developing liver injury. Previous studies have demonstrated that thymoquinone (TQ) exhibits hepatoprotective propertiesas well as. The present study aimed to investigate the underlying …
Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3.
PMID: Chem Biol Interact. 2019 Aug 18:108799. Epub 2019 Aug 18. PMID: 31433961 Abstract Title: Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3. Abstract: Black seed (Nigella sativa) oil has been used in various dermatological applications, and its major constituent, thymoquinone (TQ) has been shown to exhibit antiproliferative activity against …
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