PMID: Gene. 2019 Jul 1 ;712:143956. Epub 2019 Jul 1. PMID: 31271843 Abstract Title: Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells. Abstract: Gastric cancer represents a common malignancy of digestive tract with high incidence and mortality. Increasing evidence suggests that the growth of gastric tumor cells relies largely …
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Tuscan varieties of sweet cherry are rich sources of ursolic and oleanolic acid.
PMID: Molecules. 2019 Apr 22 ;24(8). Epub 2019 Apr 22. PMID: 31013661 Abstract Title: Tuscan Varieties of Sweet Cherry Are Rich Sources of Ursolic and Oleanolic Acid: Protein Modeling Coupled to Targeted Gene Expression and Metabolite Analyses. Abstract: The potential of six ancient Tuscan sweet cherry (L.) varieties as a source of health-promoting pentacyclic triterpenes …
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Oleanolic acid inhibits cell proliferation migration and invasion and induces SW579 thyroid cancer cell line apoptosis.
PMID: Anticancer Drugs. 2019 Mar 14. Epub 2019 Mar 14. PMID: 30882397 Abstract Title: Oleanolic acid inhibits cell proliferation migration and invasion and induces SW579 thyroid cancer cell line apoptosis by targeting forkhead transcription factor A. Abstract: Oleanolic acid (OA) is a naturally occurring triterpenoid that possesses antitumor activity against several tumor cell lines. However, …
Oleanolic acid ameliorates risk factors of cardiovascular diseases in a diet-Induced pre-diabetic rat model.
PMID: Molecules. 2019 Jan 18 ;24(2). Epub 2019 Jan 18. PMID: 30669379 Abstract Title: Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model: Effects on Selected Cardiovascular Risk Factors. Abstract: The pathogenesis of prediabetes is associated with risk factors such as chronic consumption of an unhealthy diet. Recent …
Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity.
PMID: Cell Death Discov. 2018 ;4:48. Epub 2018 Oct 15. PMID: 30345079 Abstract Title: Oleanolic acid enhances neural stem cell migration, proliferation, and differentiation in vitro by inhibiting GSK3β activity. Abstract: Oleanolic acid (OA), one of the bioactive ingredients in ginseng, has been reported to have neuroprotective activities. However, the effects and its mechanism on …
Oleanolic acid inhibits epithelial-mesenchymal transition of hepatocellular carcinoma.
PMID: Mol Cancer Ther. 2019 01 ;18(1):62-74. Epub 2018 Oct 8. PMID: 30297361 Abstract Title: Oleanolic Acid Inhibits Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Promoting iNOS Dimerization. Abstract: Oleanolic acid exhibits extensive pharmacologic activities and takes significant antitumor effects. Its pharmacologic mechanism, however, still remained to be further clarified. In this study, we demonstrated that …
Ursolic acid exhibits antiviral activity suggesting that this chemical could be potentially used as a new anti-Rotavirus therapeutic compound.
PMID: Int J Antimicrob Agents. 2019 Jul 26. Epub 2019 Jul 26. PMID: 31356859 Abstract Title: URSOLIC ACID: A NOVEL ANTIVIRAL COMPOUND INHIBITING ROTAVIRUS INFECTION IN VITRO. Abstract: Rotavirus is one of the leading causes of severe acute gastroenteritis in children under five years of age, mainly affecting developing countries. Once the disease is acquired, …
Ursolic acid is a potential anti-inflammatory natural compound for treating acute kidney injury by inducing autophagy.
PMID: Cytokine. 2019 Jul 11 ;123:154726. Epub 2019 Jul 11. PMID: 31302461 Abstract Title: Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy. Abstract: There is an urgent need for effective treatments to reduce the large and growing burden of acute kidney injury (AKI) and its consequences. Inflammation is believed to play …
Ursolic acid can effectively inhibit the proliferation and migration and induce apoptosis of gastric cancer cells.
PMID: Evid Based Complement Alternat Med. 2019 ;2019:2474805. Epub 2019 Jun 9. PMID: 31281396 Abstract Title: Ursolic Acid Inhibits Epithelial-Mesenchymal Transition through the Axl/NF-B Pathway in Gastric Cancer Cells. Abstract: Background: Ursolic acid (UA) is an antitumor component derived from Chinese herbal medicine; this study is to observe the effects of UA on epithelial-mesenchymal transition …
Ursolic acid protected lung of rats from damage induced by cigarette smoke extract.
PMID: Front Pharmacol. 2019 ;10:700. Epub 2019 Jun 20. PMID: 31281258 Abstract Title: Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract. Abstract: We found previously that ursolic acid (UA) administration could alleviate cigarette smoke-induced emphysema in rats partly through the unfolded protein response (UPR) PERK-CHOP and Nrf2 pathways, thus alleviating …
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