PMID: Redox Biol. 2018 10 ;19:11-21. Epub 2018 Jul 21. PMID: 30096613 Abstract Title: Nrf2 expression and function, but not MT expression, is indispensable for sulforaphane-mediated protection against intermittent hypoxia-induced cardiomyopathy in mice. Abstract: We reported previously that nuclear factor erythroid 2-related factor 2 (Nrf2) and metallothionein (MT) play critical roles in preventing intermittent hypoxia …
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Given its anticarcinogenic, anti-inflammatory, antioxidant properties, these authors conclude that sulforaphane could be considered as a phytochemical at the forefront of natural medicine.
PMID: Food Funct. 2018 May 23 ;9(5):2589-2606. PMID: 29701207 Abstract Title: New highlights on the health-improving effects of sulforaphane. Abstract: In this paper, we review recent evidence about the beneficial effects of sulforaphane (SFN), which is the most studied member of isothiocyanates, on both in vivo and in vitro models of different diseases, mainly diabetes …
Sulforaphane elicits antioxidant, anti-inflammatory, and extracellular matrix remodelling effects in a rat model of diabetic peripheral neuropathy.
PMID: Inflammation. 2018 Aug ;41(4):1460-1476. PMID: 29704151 Abstract Title: Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy. Abstract: The peripheral nervous system is one of many organ systems that can be profoundly impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative effect on patients' …
Broccoli sprout extract containing sulforaphane attentuated alcohol-induced oxidative stress and endoplasmic reticulum stress through restoration of antioxidant enzyme function in mice.
PMID: J Agric Food Chem. 2018 Jun 6 ;66(22):5574-5580. Epub 2018 May 23. PMID: 29730925 Abstract Title: Broccoli Sprout Extract Alleviates Alcohol-Induced Oxidative Stress and Endoplasmic Reticulum Stress in C57BL/6 Mice. Abstract: The potential efficacy of sulforaphane in protecting alcohol-induced hepatic injury in vivo and its underlying mechanism were investigated. Male C57BL/6 mice were orally …
Sulforaphane protects against oxidative stress in culture of adult cardiomyocytes.
PMID: Biomed Pharmacother. 2018 Aug ;104:165-171. Epub 2018 May 15. PMID: 29772437 Abstract Title: Sulforaphane effects on oxidative stress parameters in culture of adult cardiomyocytes. Abstract: The aim of this study was to analyse the effect of sulforaphane (SFN) in cultures of adult cardiomyocytes, evaluating oxidative stress at different times. Cells were isolated, cultured, and …
Authors conclude that data from this study provides evidence for the use of sulforaphane in preventing stroke in selected high-risk patient cohorts.
PMID: Br J Pharmacol. 2018 08 ;175(16):3333-3346. Epub 2018 Jul 3. PMID: 29797311 Abstract Title: The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction. Abstract: BACKGROUND AND PURPOSE: Platelet activation provides a critical link between inflammation and thrombosis. Sulforaphane (SFN), a naturally occurring isothiocyanate, has been shown to display both anti-inflammatory and …
Sulforaphene inhibits liver cancer cell proliferation by stimulating apoptosis and causing cytotoxicity.
PMID: Nutrients. 2018 Jun 4 ;10(6). Epub 2018 Jun 4. PMID: 29866995 Abstract Title: Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells. Abstract: Glucoraphenin, a glucosinolate present in large quantities in radish is hydrolysed by myrosinase to form the isothiocyanate sulforaphene, which is believed to be responsible for its chemopreventive …
Sulforaphane attentuates cadmium-induced carcinogenesis through Nrf2, antioxidant, and autophagy mechanisms.
PMID: Toxicol Appl Pharmacol. 2018 08 15 ;353:23-30. Epub 2018 Jun 6. PMID: 29885333 Abstract Title: Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane. Abstract: Environmental and occupational exposures to cadmium increase the risk of various cancers, including lung cancer. The carcinogenic mechanism of cadmium, including its prevention remains to …
Week-long oral administration of sulforaphane increased blood and thalamic glutathione levels in healthy human subjects.
PMID: Mol Neuropsychiatry. 2018 May ;3(4):214-222. Epub 2018 Apr 17. PMID: 29888232 Abstract Title: Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study. Abstract: Schizophrenia and other neuropsychiatric disorders await mechanism-associated interventions. Excess oxidative stress is increasingly appreciated to participate in the pathophysiology of brain disorders, and decreases in the …
Free radicals enhance the activation of Antioxidant Response Element (ARE) by sulforaphane, despite suppression of Nrf2 nuclear accumulation.
PMID: Free Radic Biol Med. 2018 08 20 ;124:532-540. Epub 2018 Jun 30. PMID: 29969714 Abstract Title: Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation. Abstract: The transcription factor Nrf2 is a master regulator of antioxidant and cytoprotective genes, binding …
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