PMID: Oxid Med Cell Longev. 2019 ;2019:8639618. Epub 2019 Feb 24. PMID: 30918581 Abstract Title: Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus. Abstract: Background: The potential mechanism of postoperative cognitive impairment is still largely unclear. The activation of NLRP3 inflammasome had been reported …
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Honokiol induces apoptotic cell death by oxidative burst and mitochondrial hyperpolarization of bladder cancer cells.
PMID: Exp Ther Med. 2019 May ;17(5):4213-4222. Epub 2019 Mar 20. PMID: 30988795 Abstract Title: Honokiol induces apoptotic cell death by oxidative burst and mitochondrial hyperpolarization of bladder cancer cells. Abstract: Bladder cancer is one of the most common types of malignant tumor worldwide. Current treatments, including chemo-/radiotherapy, only have limited efficacy on bladder cancer …
Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.
PMID: Pharmacol Res. 2019 Jun ;144:192-209. Epub 2019 Apr 17. PMID: 31002949 Abstract Title: Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets. Abstract: In spite of billions of dollars expended on cancer research every year, the incidence rate and the mortality rate due to this widespread disease has increased drastically …
Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury.
PMID: Chem Biol Interact. 2019 Jul 1 ;307:82-90. Epub 2019 Apr 29. PMID: 31047918 Abstract Title: Honokiol post-treatment ameliorates myocardial ischemia/reperfusion injury by enhancing autophagic flux and reducing intracellular ROS production. Abstract: Honokiol (HKL) is a natural low-molecular-weight biphenolic compound derived from the bark of magnolia trees. Previous studies indicate that HKL exerts potent cardioprotective …
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Honokiol can protect against type 2 diabetes by improving insulin resistance, glucose and lipid metabolism, and inflammation.
PMID: Int J Mol Sci. 2019 May 9 ;20(9). Epub 2019 May 9. PMID: 31075962 Abstract Title: Honokiol Improves Insulin Resistance, Hepatic Steatosis, and Inflammation in Type 2 Diabetic/Mice. Abstract: This study focuses on the effect of honokiol (HON) on glucose homeostasis, insulin resistance, dyslipidemia, hepatic steatosis, and inflammation in type 2 diabetic/mice. Male C57BL/KsJ-/mice …
Honokiol has the potential to be a therapeutic option for neuroblastomas.
PMID: Am J Chin Med. 2019 ;47(4):895-912. Epub 2019 May 15. PMID: 31091975 Abstract Title: Honokiol Induces Autophagic Apoptosis in Neuroblastoma Cells through a P53-Dependent Pathway. Abstract: In children, neuroblastomas are the most common and deadly solid tumor. Our previous studies showed that honokiol can cross the blood-brain barrier and kill neuroblastoma cells. In this …
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Honokiol alleviates acetaminophen-induced hepatotoxicity.
PMID: Life Sci. 2019 Aug 1 ;230:97-103. Epub 2019 May 24. PMID: 31129139 Abstract Title: Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver. Abstract: AIM: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major …
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Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer.
PMID: Biomed Pharmacother. 2019 Jun 5 ;117:109058. Epub 2019 Jun 5. PMID: 31176168 Abstract Title: Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer. Abstract: PURPOSE: In this study, we aimed to explore key micro(mi)RNAs and their potential regulatory mechanisms induced by honokiol treatment in non-small cell lung …
Honokiol inhibits breast cancer cell metastasis.
PMID: Acta Pharmacol Sin. 2019 Jun 24. Epub 2019 Jun 24. PMID: 31235819 Abstract Title: Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation. Abstract: Honokiol (HNK), an active compound isolated from traditional Chinese medicine Magnolia officinalis, has shown potent anticancer activities. In the present study, we investigated the …
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Honokiol attenuates the memory impairments, oxidative stress, neuroinflammation, and GSK-3β activation in vascular dementia rats.
PMID: J Alzheimers Dis. 2019 Jul 16. Epub 2019 Jul 16. PMID: 31322570 Abstract Title: Honokiol Attenuates the Memory Impairments, Oxidative Stress, Neuroinflammation, and GSK-3β Activation in Vascular Dementia Rats. Abstract: Vascular dementia (VaD) is caused by chronic decreases in brain blood flow and accounts for 15-20% of dementia cases worldwide. In contrast to Alzheimer's …
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