Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans.

PMID:  Free Radic Biol Med. 2018 12 ;129:310-322. Epub 2018 Sep 25. PMID: 30266681 Abstract Title:  Lonicera japonica extends lifespan and healthspan in Caenorhabditis elegans. Abstract:  Lonicera japonica (LJ) is widely used as the local medicine to improve body and prevent ills in China, but mechanisms of its healthy beneficial effects remain largely unclear. Here, …

Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide.

PMID:  PLoS One. 2018 ;13(10):e0204152. Epub 2018 Oct 8. PMID: 30296293 Abstract Title:  Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide. Abstract:  Lonicera japonica is a typical Chinese herbal medicine. We previously reported a method to isolate polysaccharides from Lonicera japonica (LJP). In this study, we first performed …

Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica.

PMID:  Int J Biol Macromol. 2019 Feb 15 ;123:801-809. Epub 2018 Nov 13. PMID: 30445085 Abstract Title:  Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats. Abstract:  In this present study, we investigated the anti-hyperuricemic and anti-gouty arthritis effect of a puried water-soluble polysaccharide (LJP-1) obtained from Lonicera japonica. A …

Therapeutic promises of Chlorogenic acid with special emphasis on its anti-obesity property.

PMID:  Curr Mol Pharmacol. 2019 Jul 16. Epub 2019 Jul 16. PMID: 31333144 Abstract Title:  Therapeutic promises of Chlorogenic acid with special emphasis on its anti-obesity property. Abstract:  BACKGROUND: Chlorogenic acid (CGA) is a quinic acid conjugate of caffeic acid. It is an ester formed between caffeic acid and the 3-hydroxyl of L-quinic acid. This …

A water extract of Lonicera japonica has a gastroprotective effect via antioxidant and anti-inflammatory activities.

PMID:  J Med Food. 2019 Feb ;22(2):140-151. Epub 2019 Jan 24. PMID: 30676853 Abstract Title:  BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities. Abstract:  The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and …

Effects of a novel biflavonoid of Lonicera japonica flower buds on modulating apoptosis under different oxidative conditions in hepatoma cells.

PMID:  Phytomedicine. 2019 Apr ;57:282-291. Epub 2018 Dec 31. PMID: 30802714 Abstract Title:  Effects of a novel biflavonoid of Lonicera japonica flower buds on modulating apoptosis under different oxidative conditions in hepatoma cells. Abstract:  BACKGROUND: In our previous work, we purified a novel biflavonoid named Japoflavone D (JFD) from Lonicera japonica flower buds. Biflavonoids are …

Lonicerin was proven to be an effective inhibitor in-vitro of P. aeruginosa infection.

PMID:  J Ethnopharmacol. 2019 Jul 15 ;239:111909. Epub 2019 Apr 23. PMID: 31026553 Abstract Title:  Lonicerin, an anti-algE flavonoid against Pseudomonas aeruginosa virulence screened from Shuanghuanglian formula by molecule docking based strategy. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: The Shuanghuanglian formula (SF) is a famous antimicrobial and antiviral traditional Chinese medicine that is made of Lonicera japonica Thunb., …

The results suggested that L. japonica polyphenols could be explored as a natural antioxidant and tyrosinase inhibitor.

PMID:  Food Sci Nutr. 2019 May ;7(5):1786-1794. Epub 2019 Apr 21. PMID: 31139392 Abstract Title:  Extraction optimization, antioxidant activity, and tyrosinase inhibitory capacity of polyphenols from. Abstract:  The objective of this research was twofold: first, to optimize the extraction process ofpolyphenols using a response surface methodology, and second, to study the antioxidant activity and tyrosinase …

Sulforaphane enhances leptin sensitivity and prevents weigh gain in diet-induced obese mice.

PMID:  Eur J Pharmacol. 2018 Sep 15 ;835:108-114. Epub 2018 Jul 29. PMID: 30063917 Abstract Title:  Sulforaphane improves leptin responsiveness in high-fat high-sucrose diet-fed obese mice. Abstract:  Diet-induced obesity (DIO) is commonly associated with hyperleptinemia and leptin resistance. Leptin acts centrally to inhibit food intake and increase energy expenditure, thereby preventing body weight gain. Resistance …

This study elucidates the mechanisms behind the neurovascular protective effects of sulforaphane.

PMID:  Sci Rep. 2018 Aug 23 ;8(1):12708. Epub 2018 Aug 23. PMID: 30139948 Abstract Title:  In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity. Abstract:  Sulforaphane (SFN) has been shown to protect the brain vascular system and effectively reduce ischemic injuries and cognitive deficits. …

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