PMID: Food Funct. 2018 Sep 19 ;9(9):4695-4701. PMID: 30091431 Abstract Title: Sulforaphane ameliorates glucose intolerance in obese mice via the upregulation of the insulin signaling pathway. Abstract: Sulforaphane (SFN) is a dietary component with multiple bioactivities; however, its role in obesity-related metabolic derangement remains unclear. Here, the effect of SFN on the glucose intolerance of …
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This review establishes sulforaphane as a safe and non-toxic chemopreventative agent and indicates the need for more research for its use in human cancers as a single agent or as part of combination therapy.
PMID: Drug Des Devel Ther. 2018 ;12:2905-2913. Epub 2018 Sep 11. PMID: 30254420 Abstract Title: Chemopreventive activity of sulforaphane. Abstract: Cancer is one of the major causes of morbidity and mortality in the world. Carcinogenesis is a multistep process induced by genetic and epigenetic changes that disrupt pathways controlling cell proliferation, apoptosis, differentiation, and senescence. …
Sulforaphane suppresses an animal model of skin cancer in a pleiotropic manner.
PMID: Exp Dermatol. 2019 Jan ;28(1):28-34. Epub 2018 Dec 11. PMID: 30315662 Abstract Title: Antitumor activity of sulforaphane in mice model of skin cancer via blocking sulfatase-2. Abstract: Although there are many treatment options for skin cancer, the chemotherapeutic agents for skin cancer are linked with many adverse effects as well as the development of …
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Sulforaphane inhibits Wnt/β-catenin signaling in colorectal cancer cells, supressing proliferation and inducing cell death.
PMID: Oncotarget. 2018 Sep 21 ;9(74):33982-33994. Epub 2018 Sep 21. PMID: 30338040 Abstract Title: Sulforaphane inhibits growth and blocks Wnt/β-catenin signaling of colorectal cancer cells. Abstract: The naturally occurring isothiocyanate sulforaphane (SFN) from cruciferous vegetables is associated with growth inhibition of various cancer types, including colorectal cancer. Colorectal cancer is most frequently driven by hyperactive …
Sulforaphane inhibits pancreatic cancer proliferation through AMPK activation and Nrf2 translocation in vitro and in vivo.
PMID: Cell Physiol Biochem. 2018 ;50(3):1201-1215. Epub 2018 Oct 24. PMID: 30355942 Abstract Title: Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling. Abstract: BACKGROUND/AIMS: Sulforaphane (SFN) is known for its potent bioactive properties, such as anti-inflammatory and anti-tumor effects. However, its anti-tumor effect on pancreatic cancer is …
Sulforaphane may prevent or treat breast cancer by reversing estrogen-induced metabolic changes or alterations in methylation.
PMID: FEBS Open Bio. 2018 Dec ;8(12):2022-2034. Epub 2018 Nov 14. PMID: 30524952 Abstract Title: Sulforaphane-induced metabolomic responses with epigenetic changes in estrogen receptor positive breast cancer cells. Abstract: Estrogen is a risk factor for breast cancer. The isothiocyanate sulforaphane (SFN), found in cruciferous vegetables, has been identified as an effective chemopreventive agent, and may …
Sulforaphane enhances lipid metabolism through improved mitochondrial function by Nrf-2 and PGC-1a-dependent mechanisms.
PMID: Mol Nutr Food Res. 2019 02 ;63(4):e1800795. Epub 2019 Jan 11. PMID: 30578708 Abstract Title: Sulforaphane Improves Lipid Metabolism by Enhancing Mitochondrial Function and Biogenesis In Vivo and In Vitro. Abstract: SCOPE: Sulforaphane (SFN) is reported to reduce the accumulation of lipids. However, the underling mechanism remains unclear. In this study, the potential of …
Sulforaphane decreases leukemia cell viability in vitro by inhibiting NADPH oxidase enzymes and redox transporter signaling.
PMID: Oxid Med Cell Longev. 2018 ;2018:4125297. Epub 2018 Nov 18. PMID: 30581529 Abstract Title: Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells. Abstract: Sulforaphane, a biologically active isothiocyanate compound extracted from cruciferous vegetables, has been shown to exert cytotoxic effects on many human cancer cells, including leukemia. However, the exact molecular mechanisms behind the …
Sulforaphane elicits insulin-sensitizing, hepatoprotective, and vasculoprotective effects comparable to that of pioglitazone in insulin-resistant rats.
PMID: Environ Toxicol Pharmacol. 2019 Feb ;66:43-54. Epub 2018 Dec 13. PMID: 30597379 Abstract Title: Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats. Abstract: The purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard …
Sulforaphane suppresses proliferation and enhances apoptosis of gastric cancer stem cells in vitro.
PMID: Int J Food Sci Nutr. 2019 Aug ;70(5):570-578. Epub 2019 Jan 9. PMID: 30624124 Abstract Title: Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway. Abstract: Sulforaphane (SFN) is the major component extracted from broccoli/broccoli sprouts. It has been shown to possess anti-cancer activity. Gastric cancer is common cancer worldwide. The objective …
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