Category Archives: Uncategorized

PMID:  Nutr Metab (Lond). 2019 ;16:25. Epub 2019 Apr 25. PMID: 31049071 Abstract Title:  Myricetin ameliorates atherosclerosis in the low-density-lipoprotein receptor knockout mice by suppression of cholesterol accumulation in macrophage foam cells. Abstract:  Background: Myricetin, a major flavonoid found in several foods including berries, grapes and wine, exhibited strong antioxidant potency, yet the effect on …

Continue reading “Myricetin may have an important therapeutic function for atherosclerosis.”

PMID:  Nutr Metab (Lond). 2019 ;16:27. Epub 2019 May 2. PMID: 31073320 Abstract Title:  Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499. Abstract:  Background: Reprogramming of fast-to-slow myofiber switch can improve endurance capacity and alleviate fatigue. Accumulating evidence suggests that a muscle-specific microRNA, miR-499 plays a crucial role in myofiber type …

Continue reading “Myricetin improves endurance capacity by inducing muscle fiber type conversion via miR-499.”

PMID:  J Pharmacol Sci. 2019 May ;140(1):62-72. Epub 2019 May 4. PMID: 31130510 Abstract Title:  Myricetin ameliorated ischemia/reperfusion-induced brain endothelial permeability by improvement of eNOS uncoupling and activation eNOS/NO. Abstract:  Disruption of the blood-brain barrier (BBB) has been considered as a major pathological change in stroke. eNOS/NO play a key role in maintain BBB function. …

Continue reading “Myricetin ameliorated ischemia/reperfusion-induced brain endothelial permeability.”

PMID:  Mol Nutr Food Res. 2019 Jun 5:e1801393. Epub 2019 Jun 5. PMID: 31168926 Abstract Title:  Myricetin Ameliorates Ethanol-Induced Lipid Accumulation in Liver Cells by Reducing Fatty Acid Biosynthesis. Abstract:  SCOPE: Alcoholic liver disease is a serious threat to human health. The development of drug candidates from complementary and alternative medicines is an attractive approach. …

Continue reading “Myricetin ameliorates ethanol-induced lipid accumulation in liver cells.”

PMID:  Nat Med. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31332392 Abstract Title:  Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Abstract:  Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovulatory dysfunction and polycystic ovaries, and is often accompanied by insulin resistance. The mechanism of ovulatory dysfunction and insulin resistance in PCOS remains …

Continue reading “Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome.”

PMID:  Free Radic Res. 2019 Jul 10:1-311. Epub 2019 Jul 10. PMID: 31290351 Abstract Title:  Modulation of selenium-dependent glutathione peroxidase activity enhances doxorubicin-induced apoptosis, tumor cell killing, and hydroxyl radical production in human NCI/ADR-RES cancer cells despite high-level P-glycoprotein expression. Abstract:  To define the role of glutathione peroxidase (GPx) in modulating the oxygen radical-related cytotoxicity …

Continue reading “Modulation of selenium-dependent glutathione peroxidase activity enhances doxorubicin-induced apoptosis.”

PMID:  Front Pharmacol. 2019 ;10:647. Epub 2019 Jun 11. PMID: 31244660 Abstract Title:  Myricetin Attenuated Diabetes-Associated Kidney Injuries and DysfunctionRegulating Nuclear Factor (Erythroid Derived 2)-Like 2 and Nuclear Factor-κB Signaling. Abstract:  Previous studies have suggested that myricetin (Myr) could promote the expression and nuclear translocation of nuclear factor (erythroid-derived 2)-like (Nrf2). This study aimed to …

Continue reading “Myricetin attenuated diabetes-associated kidney injuries and dysfunction.”

PMID:  Anat Rec (Hoboken). 2019 Jul 2. Epub 2019 Jul 2. PMID: 31266091 Abstract Title:  Myricetin Inhibits Breast Tumor Growth and Angiogenesis by Regulating VEGF/VEGFR2 and p38MAPK Signaling Pathways. Abstract:  Tumor angiogenesis is an important cause of tumor growth and metastasis. Myricetin is a flavonoid component used in traditional Chinese medicine that has been demonstrated …

Continue reading “Myricetin could significantly inhibit tumor angiogenesis and has potential as a chemopreventive agent.”

PMID:  Nat Med. 2019 Jul 22. Epub 2019 Jul 22. PMID: 31332389 Abstract Title:  Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice. Abstract:  The gut microbiome is emerging as a key regulator of several metabolic, immune and neuroendocrine pathways. Gut microbiome deregulation has been implicated in major conditions such as obesity, type …

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PMID:  Nutrients. 2019 May 27 ;11(5). Epub 2019 May 27. PMID: 31137828 Abstract Title:  Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis. Abstract:  Sulforaphane (SFA), a naturally active isothiocyanate compound from cruciferous vegetables used in clinical trials for cancer treatment, was found to possess potency to alleviate insulin resistance. But its …

Continue reading “Sulforaphane prevents hepatic insulin resistance through a ceramide-dependent mechanism.”