Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

PMID:  Arch Biochem Biophys. 2018 11 1 ;657:65-73. Epub 2018 Sep 15. PMID: 30222954 Abstract Title:  Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5. Abstract:  Tobacco and alcohol are often co-abused. Nicotine can enhance alcoholic fatty liver, and CYP2A6 (CYP2A5 in mice), a major metabolism enzyme for nicotine, can be induced by alcohol. …

Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells.

PMID:  Toxicol Lett. 2018 Dec 15 ;299:40-46. Epub 2018 Sep 15. PMID: 30227238 Abstract Title:  Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Abstract:  Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is …

Enteral exposure to P histicola suppresses arthritis via mucosal regulation.

PMID:  Arthritis Rheumatol. 2016 12 ;68(12):2878-2888. PMID: 27337150 Abstract Title:  Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice. Abstract:  OBJECTIVE: The gut microbiome regulates host immune homeostasis. Rheumatoid arthritis (RA) is associated with intestinal dysbiosis. This study was undertaken to test the ability of a human gut-derived commensal to modulate immune …

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Many of you have asked about why I love this breed of dog… I’ve had four generations of Rhodesian Ridgebacks and thoroughly enjoyed every minute with these intelligent, affectionate companions. I seek out this… https://www.instagram.com/p/B0Rya7PpZhM/?igshid=1r9h6p4xdeckf …

This study demonstrates that sulforaphane targets multiple signaling pathways to suppress ovarian cancer in vitro and in vivo.

PMID:  Int J Mol Med. 2018 Nov ;42(5):2447-2458. Epub 2018 Sep 6. PMID: 30226534 Abstract Title:  Sulforaphane regulates apoptosis- and proliferation‑related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer. Abstract:  Ovarian cancer is currently the most life‑threatening type of gynecological malignancy with limited treatment options. Therefore, improved targeted therapies are required to combat …

Sulforphane’s antioxidant properties make it an effective neuroprotective agent. More studies are needed to determine the exact implications in neurological disease.

PMID:  Brain Circ. 2019 Apr-Jun;5(2):74-83. Epub 2019 Jun 27. PMID: 31334360 Abstract Title:  The neuroprotective mechanisms and effects of sulforaphane. Abstract:  Sulforaphane (SFN) is a phytochemical found in cruciferous vegetables. It has been shown to have many protective effects against many diseases, including multiple types of cancer. SFN is a potent activator of the nuclear …

Sulforaphane’s anti-inflammatory, antioxidant, and neuroprotective benefits attentuate autoimmune encephalomyelitis in an animal model of Multiple Sclerosis.

PMID:  J Korean Med Sci. 2019 Jul 22 ;34(28):e197. Epub 2019 Jul 22. PMID: 31327180 Abstract Title:  The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis. Abstract:  BACKGROUND: Multiple sclerosis (MS) is an immune-associated inflammatory disorder of the central nervous system and results in serious disability. Although many disease-modifying therapy drugs have been …

Neonatal monosodium glutamate administration disrupts place learning and alters hippocampal-prefrontal learning-related theta activity.

PMID:  Neuroscience. 2019 Jul 9 ;414:228-244. Epub 2019 Jul 9. PMID: 31299349 Abstract Title:  Neonatal Monosodium Glutamate Administration Disrupts Place Learning and Alters Hippocampal-Prefrontal Learning-Related Theta Activity in the Adult Rat. Abstract:  Neonatal treatment with monosodium glutamate causes profound deficits in place learning and memory in adult rats evaluated in the Morris maze. Theta activity …

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