PMID: Biochem Pharmacol. 2010 Jan 15 ;79(2):130-6. Epub 2009 Aug 19. PMID: 19698702 Abstract Title: Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines. Abstract: Artemisinin derivatives are well-tolerated anti-malaria drugs that also exert anti-cancer activity. Here, we investigated artemisinin and its derivatives dihydroartemisinin and artesunate in a panel of chemosensitive and …
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Artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells.
PMID: Exp Mol Pathol. 2019 04 ;107:10-22. Epub 2019 Jan 17. PMID: 30660598 Abstract Title: The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells. Abstract: Breast cancer is the most prevalent cancer diagnosis in women, with triple-negative and human epidermal growth factor 2 (HER2)-enriched advanced …
Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis.
PMID: Eur Rev Med Pharmacol Sci. 2014 ;18(21):3199-204. PMID: 25487928 Abstract Title: Artesunate restraining MAPK passage by smad7 to resist pulmonary fibrosis. Abstract: OBJECTIVES: This study aims to discuss the function and molecular mechanism of artesunate in resisting pulmonary fibrosis.METHODS: Artesunate was used to stimulate the HFL-I cell line, which restrains the expression of Smad7 …
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Artesunate demonstrates in vitro synergism with several antiviral agents against human cytomegalovirus.
PMID: Antivir Ther. 2016 ;21(6):535-539. Epub 2016 Feb 4. PMID: 26844400 Abstract Title: Artesunate demonstrates in vitro synergism with several antiviral agents against human cytomegalovirus. Abstract: BACKGROUND: Human cytomegalovirus (HCMV) infections remain a major problem in immunocompromised patients. Three antiviral agents, ganciclovir (GCV), foscarnet (FOS) and cidofovir (CDV), are currently approved for the treatment of …
Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers.
PMID: Artif Cells Nanomed Biotechnol. 2016 Dec ;44(8):1979-1987. Epub 2016 Jan 11. PMID: 26754823 Abstract Title: Enhancing activity of artesunate against breast cancer cells via induced-apoptosis pathway by loading into lipid carriers. Abstract: Artesunate-loaded nanostructured lipid carriers (ART-NLCs) were prepared by hot homogenization followed by ultrasonication technique. The optimized ART-NLC demonstrated a particle size of …
A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies.
PMID: Cancer Chemother Pharmacol. 2018 03 ;81(3):587-596. Epub 2018 Feb 1. PMID: 29392450 Abstract Title: A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies. Abstract: PURPOSE: The artemisinin class of anti-malarial drugs has shown significant anti-cancer activity in pre-clinical models. Proposed anti-cancer mechanisms include DNA damage, inhibition of angiogenesis, TRAIL-mediated …
Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells.
PMID: Exp Cell Res. 2016 10 1 ;347(2):251-60. Epub 2016 Jun 18. PMID: 27327234 Abstract Title: Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells. Abstract: Artesunate (ARS), an artemisinin derivative, has been demonstrated to possess antitumor activity in various human tumor cells. This study aims to investigate the molecular …
Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damage
PMID: J Pharmacol Sci. 2018 Oct ;138(2):131-137. Epub 2018 Sep 29. PMID: 30337244 Abstract Title: Artesunate enhances radiosensitivity of esophageal cancer cells by inhibiting the repair of DNA damage. Abstract: Radiotherapy plays an important therapeutic role in esophageal cancer (EC). However, acquired radioresistance impairs the efficacy of radiotherapy, often leading to treatment failure. Therefore, it …
Artesunate has a potential to inhibit hepatitis C virus replication.
PMID: Virus Genes. 2016 Feb ;52(1):22-8. Epub 2016 Jan 6. PMID: 26739460 Abstract Title: Artesunate, an anti-malarial drug, has a potential to inhibit HCV replication. Abstract: Hepatitis C virus (HCV) infection is a major global health issue. Although the search for HCV treatments has resulted in great achievements, the current treatment methods have limitations, and …
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Artesunate inhibits proliferation of glioblastoma cells by arresting cell cycle.
PMID: Zhongguo Zhong Yao Za Zhi. 2018 Feb ;43(4):772-778. PMID: 29600654 Abstract Title: [Artesunate inhibits proliferation of glioblastoma cells by arresting cell cycle]. Abstract: Glioblastoma is a common brain tumor and the overall survival rate of the patients is very low, so it is an effective way to develop the potential chemotherapy or adjuvant chemotherapy …
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