Category Archives: Uncategorized

PMID:  Antimicrob Agents Chemother. 2011 Nov ;55(11):5159-67. Epub 2011 Sep 6. PMID: 21896910 Abstract Title:  Griffithsin has antiviral activity against hepatitis C virus. Abstract:  Hepatitis C virus (HCV)-infected patients undergoing liver transplantation universally experience rapid reinfection of their new liver graft. Current treatment protocols do not prevent graft reinfection and, in addition, an accelerated disease …

Continue reading “Griffithsin has antiviral activity against hepatitis C virus.”

PMID:  Plant Mol Biol. 2018 Jul ;97(4-5):357-370. Epub 2018 Jun 9. PMID: 29948657 Abstract Title:  High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves. Abstract:  The potent anti-HIV microbicide griffithsin was expressed to high levels in tobacco chloroplasts, enabling efficient purification from both …

Continue reading “High-level expression of the HIV entry inhibitor griffithsin from the plastid genome and retention of biological activity in dried tobacco leaves.”

PMID:  Viruses. 2016 12 17 ;8(12). Epub 2016 Dec 17. PMID: 27999325 Abstract Title:  Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses. Abstract:  Griffithsin (GRFT) is a red alga-derived lectin with demonstrated broad spectrum antiviral activity against enveloped viruses, including severe acute respiratory syndrome-Coronavirus (SARS-CoV), Japanese encephalitis virus (JEV), …

Continue reading “Pharmacokinetics of the antiviral lectin griffithsin administered by different routes indicates multiple potential uses.”

PMID:  J Virol. 2013 Jun ;87(11):6257-69. Epub 2013 Mar 27. PMID: 23536670 Abstract Title:  Griffithsin protects mice from genital herpes by preventing cell-to-cell spread. Abstract:  Griffithsin, which binds N-linked glycans on gp120 to prevent HIV entry, has the most potent HIV-1 inhibitory activity described for any antiviral lectin and is being developed for topical preexposure …

Continue reading “These findings demonstrate that griffithsin inhibits HSV-2 by a unique mechanism of blocking cell-to-cell spread.”

PMID:  Respir Med. 2020 May 13:106026. Epub 2020 May 13. PMID: 32405162 Abstract Title:  A study on infectivity of asymptomatic SARS-CoV-2 carriers. Abstract:  Background: An ongoing outbreak of coronavirus disease 2019 (COVID-19) has spread around the world. It is debatable whether asymptomatic COVID-19 virus carriers are contagious. We report here a case of the asymptomatic …

Continue reading “Infectivity of some asymptomatic SARS-CoV-2 carriers might be weak.”

PMID:  Antimicrob Agents Chemother. 2019 12 20 ;64(1). Epub 2019 Dec 20. PMID: 31611356 Abstract Title:  Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126. Abstract:  Griffithsin (Grft) is an antiviral lectin that has been shown to potently inhibit HIV-1 by binding high-mannose N-linked glycosylation sites on …

Continue reading “Griffithsin retains anti-HIV-1 potency with changes in gp120 glycosylation and complements broadly neutralizing antibodies PGT121 and PGT126.”

PMID:  Nat Commun. 2018 09 24 ;9(1):3881. Epub 2018 Sep 24. PMID: 30250170 Abstract Title:  Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo. Abstract:  Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) strategies with proven in vivo efficacy rely on antiretroviral drugs, creating the potential for drug resistance and complicated treatment …

Continue reading “Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo.”

PMID:  Viruses. 2016 10 24 ;8(10). Epub 2016 Oct 24. PMID: 27783038 Abstract Title:  Griffithsin: An Antiviral Lectin with Outstanding Therapeutic Potential. Abstract:  Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors discovered to date. It is currently being developed as a microbicide with broad-spectrum activity against several enveloped viruses. …

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PMID:  Antiviral Res. 2016 09 ;133:1-8. Epub 2016 Jul 15. PMID: 27424494 Abstract Title:  Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin. Abstract:  Highly pathogenic human coronaviruses associated with a severe respiratory syndrome, including Middle East respiratory syndrome coronavirus (MERS-CoV), have recently emerged. The MERS-CoV epidemic started in 2012 and is still ongoing, …

Continue reading “Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin.”

PMID:  Arch Virol. 2018 Dec ;163(12):3317-3325. Epub 2018 Sep 15. PMID: 30220033 Abstract Title:  Griffithsin inhibits porcine reproductive and respiratory syndrome virus infection in vitro. Abstract:  Porcine reproductive and respiratory syndrome virus (PRRSV) is a pathogen that severely disrupts swine production. Despite sustained efforts, the disease is still endemic, with high mortality and morbidity. New antiviral …

Continue reading “The remarkable potency profile of Griffithsin supports its potential value as an antiviral agent against porcine reproductive and respiratory syndrome virus.”