Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors.

PMID:  Pharmacol Res. 2020 Mar 6 ;156:104749. Epub 2020 Mar 6. PMID: 32151683 Abstract Title:  Cannabidiol attenuates behavioral changes in a rodent model of schizophrenia through 5-HT1A, but not CB1 and CB2 receptors. Abstract:  Preclinical and clinical data indicate that cannabidiol (CBD), a non-psychotomimetic compound from the Cannabis sativa plant, can induce antipsychotic-like effects. In …

CBD reverts the mesenchymal invasive phenotype of breast cancer cells induced by the inflammatory cytokine IL-1β.

PMID:  Int J Mol Sci. 2020 Mar 31 ;21(7). Epub 2020 Mar 31. PMID: 32244518 Abstract Title:  CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β. Abstract:  Cannabidiol (CBD) has been used to treat a variety of cancers and inflammatory conditions with controversial results. In previous work, we …

Cannabidiol: A brief review of its therapeutic and pharmacologic efficacy in the management of joint disease.

PMID:  Cureus. 2020 Mar 23 ;12(3):e7375. Epub 2020 Mar 23. PMID: 32328386 Abstract Title:  Cannabidiol: A Brief Review of Its Therapeutic and Pharmacologic Efficacy in the Management of Joint Disease. Abstract:  Cannabis use in the management of musculoskeletal diseases has gained advocacy since several states have legalized its recreational use. Cannabidiol (CBD), a commercially available, non-neurotropic …

Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders.

PMID:  Int J Mol Sci. 2020 Apr 26 ;21(9). Epub 2020 Apr 26. PMID: 32357565 Abstract Title:  Cannabidiol and Other Non-Psychoactive Cannabinoids for Prevention and Treatment of Gastrointestinal Disorders: Useful Nutraceuticals? Abstract:  is an aromatic annual flowering plant with several botanical varieties, used for different purposes, like the production of fibers, the production of oil …

Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes.

PMID:  Neurosci Lett. 2020 May 1 ;729:135020. Epub 2020 May 1. PMID: 32360935 Abstract Title:  Two-weeks treatment with cannabidiol improves biophysical and behavioral deficits associated with experimental type-1 diabetes. Abstract:  The prevalence rates of depression and anxiety are at least two times higher in diabetic patients, increasing morbidity and mortality. Cannabidiol (CBD) has been identified …

CBD inhibitory effects on the NLRP3 inflammasome may contribute to the overall anti-inflammatory effects reported for this phytocannabinoid.

PMID:  J Nat Prod. 2020 May 6. Epub 2020 May 6. PMID: 32374168 Abstract Title:  Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes. Abstract:  Cannabidiol (CBD), a phytocannabinoid, has been reported to have anti-inflammatory effects associated with NLRP3 inflammasome activation, but …

CBD seems to exert an anti-inflammatory and antioxidant activity favoring a faster resolution of oral mucositis.

PMID:  Oral Dis. 2020 May 13. Epub 2020 May 13. PMID: 32400905 Abstract Title:  Cannabidiol on 5-FU-induced oral mucositis in mice. Abstract:  PURPOSE: The aim of this study was to evaluate the clinical, histological, hematological and oxidative stress effects of cannabidiol (CBD) in mice with induced oral mucositis.METHODS: We used 90 mice of the CF-1 …

From Cannabis sativa to cannabidiol: promising therapeutic candidate for the treatment of neurodegenerative diseases.

PMID:  Front Pharmacol. 2020 ;11:124. Epub 2020 Mar 6. PMID: 32210795 Abstract Title:  Fromto Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases. Abstract:  , commonly known as marijuana, contains a pool of secondary plant metabolites with therapeutic effects. BesidesΔ9-tetrahydrocannabinol that is the principal psychoactive constituent of, cannabidiol (CBD) is the most abundant nonpsychoactive …

The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis.

PMID:  Inflamm Res. 2020 Jun ;69(6):549-558. Epub 2020 Apr 1. PMID: 32239248 Abstract Title:  The anti-inflammatory and analgesic effects of formulated full-spectrum cannabis extract in the treatment of neuropathic pain associated with multiple sclerosis. Abstract:  PURPOSE: Cannabis has been used for thousands of years in many cultures for the treatment of several ailments including pain. …

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