PMID: Life Sci. 2019 Dec 15 ;239:117032. Epub 2019 Nov 6. PMID: 31704450 Abstract Title: Molecular mechanisms of curcumin and its analogs in colon cancer prevention and treatment. Abstract: Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal …
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Curcumin modulates hepatocellular carcinoma by reducing UNC119 expression.
PMID: J Environ Pathol Toxicol Oncol. 2019 ;38(3):195-203. PMID: 31679307 Abstract Title: Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression. Abstract: UNCI 19 expression has been reported to be significantly higher in hepatic cancer cells (HCC). However, the clinical significance of modulating UNC119 expression in HCC is not well understood. The study described here aimed …
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Protective effect of pterostilbene on concanavalin A-induced acute liver injury.
PMID: Food Funct. 2019 Nov 1 ;10(11):7308-7314. Epub 2019 Oct 18. PMID: 31626263 Abstract Title: Protective effect of pterostilbene on concanavalin A-induced acute liver injury. Abstract: Pterostilbene (PTE) is broadly found in berries and has antioxidant and anti-inflammatory properties. To examine the effect of PTE on acute liver injury, mice were administrated PTE prior to …
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Pterostilbene attenuates experimental atherosclerosis.
PMID: J Agric Food Chem. 2019 Nov 20 ;67(46):12752-12760. Epub 2019 Nov 8. PMID: 31642668 Abstract Title: Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells. Abstract: Atherosclerosis, the major risk of cardiovascular events, is a chronic vascular inflammatory disease. Pterostilbene is a naturally occurring dimethylated analogue of resveratrol and …
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Effects of pterostilbene on diabetes, liver steatosis and serum lipids.
PMID: Curr Med Chem. 2019 Oct 29. Epub 2019 Oct 29. PMID: 31663469 Abstract Title: Effects of pterostilbene on diabetes, liver steatosis and serum lipids. Abstract: Pterostilbene, a phenolic compound derived from resveratrol, possesses greater bioavailability than its parent compound due to the presence of two methoxyl groups. In this review, the beneficial effects of …
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Pterostilbene could be used as an anti-obesity nutraceutical.
PMID: Int J Mol Sci. 2019 Oct 29 ;20(21). Epub 2019 Oct 29. PMID: 31671737 Abstract Title: Browning Effects of a Chronic Pterostilbene Supplementation in Mice Fed a High-Fat Diet. Abstract: Obesity and related comorbidities are a major health concern. The drugs used to treat these conditions are largely inadequate or dangerous, and a well-researched …
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Melatonin and pterostilbene is a potent strategy for colorectal cancer therapy.
PMID: Cancers (Basel). 2019 Oct 29 ;11(11). Epub 2019 Oct 29. PMID: 31671847 Abstract Title: NEDD9 Inhibition by miR-25-5p Activation Is Critically Involved in Co-Treatment of Melatonin- and Pterostilbene-Induced Apoptosis in Colorectal Cancer Cells. Abstract: The underlying interaction between melatonin (MLT) and daily fruit intake still remains unclear to date, despite multibiological effects of MLT. …
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Pterostilbene is a promising neuroprotective agent.
PMID: Front Immunol. 2019 ;10:2408. Epub 2019 Oct 17. PMID: 31681297 Abstract Title: Pterostilbene Attenuates Astrocytic Inflammation and Neuronal Oxidative Injury After Ischemia-Reperfusion by Inhibiting NF-κB Phosphorylation. Abstract: Astrocyte-mediated inflammation and oxidative stress elicit cerebral ischemia-reperfusion (IR) injury after stroke. Nuclear factor (NF)-κB activates astrocytes and generates pro-inflammatory factors. The purpose of the present study …
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Pterostilbene protects cardiomyocytes from acute doxorubicin exposure-induced oxidative stress and mitochondrial damage.
PMID: Aging (Albany NY). 2019 Nov 16 ;11(22):10061-10073. Epub 2019 Nov 16. PMID: 31733141 Abstract Title: PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades. Abstract: Doxorubicin (DOX) is a widely used and potent anticancer agent, but DOX dose-dependently induced cardiotoxicity greatly limits its use in …
Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway.
PMID: Am J Transl Res. 2019 ;11(10):6356-6369. Epub 2019 Oct 15. PMID: 31737188 Abstract Title: Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway. Abstract: Amyloid-β (Aβ) is considered partially responsible for cognitive dysfunction in Alzheimer's disease (AD). Resveratrol is known as an anti-neurotoxicity potential natural product, however low blood-brain-barrier (BBB) permissibility and low oral-bioavailability …
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