Uncategorized – Page 604

Sesamin catechol glucuronides exert anti-inflammatory effects.

PMID: J Agric Food Chem. 2019 Jul 10 ;67(27):7640-7649. Epub 2019 Apr 16. PMID: 30951310 Abstract Title: Sesamin Catechol Glucuronides Exert Anti-inflammatory Effects by Suppressing Interferonβ and Inducible Nitric Oxide Synthase Expression through Deconjugation in Macrophage-like J774.1 Cells. Abstract: Sesamin, a representative sesame lignan, has health-promoting activities. Sesamin is converted into catechol derivatives and further …

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Sesame lignans suppress age-related cognitive decline in senescence-accelerated mice.

PMID: Nutrients. 2019 Jul 12 ;11(7). Epub 2019 Jul 12. PMID: 31336975 Abstract Title: Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice. Abstract: Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans …

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Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion.

PMID: Arch Med Sci. 2019 Oct ;15(6):1582-1588. Epub 2018 Dec 10. PMID: 31749888 Abstract Title: Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model. Abstract: Introduction: Mesenteric ischemia/reperfusion (I/R) injury is a serious clinical condition. There were a lot of experimental studies performed in the treatment of I/R injury. …

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Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway.

PMID: Toxicol Appl Pharmacol. 2019 Dec 3:114848. Epub 2019 Dec 3. PMID: 31809756 Abstract Title: Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway. Abstract: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer with a disappointing prognosis. The aim of this study was to investigate the anticancer effect …

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Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism.

PMID: Chronobiol Int. 2019 Dec 13:1-17. Epub 2019 Dec 13. PMID: 31833423 Abstract Title: Administration timing and duration-dependent effects of sesamin isomers on lipid metabolism in rats. Abstract: Metabolism of lipids such as cholesterol and triglycerides has daily variations and is controlled by a circadian clock. Sesamin isomers, a mixture of sesamin and episesamin (SE), …

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The results suggested that sesamin had ameliorated cisplatin nephrotoxicity.

PMID: Physiol Res. 2019 Dec 19. Epub 2019 Dec 19. PMID: 31852200 Abstract Title: Ameliorative effect of sesamin in cisplatin-induced nephrotoxicity in rats by suppressing inflammation, oxidative/nitrosative stress, and cellular damage. Abstract: Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory …

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Sesamol induced mitochondrial protection in LPS-treated cells by a mechanism involving heme oxigenase-1.

PMID: Chem Biol Interact. 2018 Dec 25 ;296:171-178. Epub 2018 Sep 24. PMID: 30261164 Abstract Title: The inhibition of heme oxigenase-1 (HO-1) abolishes the mitochondrial protection induced by sesamol in LPS-treated RAW 264.7 cells. Abstract: Redox impairment and mitochondrial dysfunction have been seen in inflammation. Thus, there is interest in studies aiming to find molecules that …

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ApoE-dependent protective effects of sesamol on high-fat diet-induced behavioral disorders.

PMID: J Agric Food Chem. 2019 Jun 5 ;67(22):6190-6201. Epub 2019 May 28. PMID: 31117496 Abstract Title: ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis. Abstract: Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of …

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These results demonstrated that sesamol is a potent depigmenting agent in the animal model.

PMID: Antioxidants (Basel). 2019 Jul 5 ;8(7). Epub 2019 Jul 5. PMID: 31284438 Abstract Title: Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin. Abstract: Melanin is synthesized through a series of oxidative reactions initiated with tyrosine and catalyzed by melanogenesis-related proteins such as tyrosinase, tyrosinase-related protein-1 (TRP-1), dopachrome tautomerase (TRP-2), and microphthalmia-associated …

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Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice.

PMID: Food Nutr Res. 2019 ;63. Epub 2019 Oct 23. PMID: 31692782 Abstract Title: Sesamol intervention ameliorates obesity-associated metabolic disorders by regulating hepatic lipid metabolism in high-fat diet-induced obese mice. Abstract: Background: Obesity has currently become a serious social problem to be solved. Sesamol, a natural bioactive substance extracted from sesame oil, has shown multiple …

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