Oleocanthal combined with lapatinib treatment synergized against HER-2 positive breast cancer.

PMID:  Nutrients. 2019 Feb 15 ;11(2). Epub 2019 Feb 15. PMID: 30781364 Abstract Title:  (-)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo. Abstract:  Dysregulation of epidermal growth factor receptor (EGFR)/human epidermal growth factor-2 (HER2) family is a hallmark of aggressive breast cancer. Small-molecule tyrosine kinase inhibitors are …

Oleocanthal might be a promising natural agent for future treatment of immune-inflammatory diseases.

PMID:  J Agric Food Chem. 2019 May 15 ;67(19):5552-5559. Epub 2019 May 1. PMID: 31042377 Abstract Title:  Oleocanthal Modulates LPS-Induced Murine Peritoneal Macrophages Activation via Regulation of Inflammasome, Nrf-2/HO-1, and MAPKs Signaling Pathways. Abstract:  The present study was designed to investigate the role of the canonical and noncanonical inflammasome, MAPKs and NRF-2/HO-1, signaling pathways involved …

Oleocanthal and extra-virgin olive oil could provide beneficial effect to slow or halt the progression of Alzheimer’s disease.

PMID:  ACS Chem Neurosci. 2019 Aug 21 ;10(8):3543-3554. Epub 2019 Jun 25. PMID: 31244050 Abstract Title:  Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice. Abstract:  Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by multiple hallmarks including extracellular amyloid (Aβ) plaques, neurofibrillary …

Inhibiting effect of oleocanthal on neuroblastoma cancer cell proliferation in culture.

PMID:  Biotech Histochem. 2019 Nov 6:1-9. Epub 2019 Nov 6. PMID: 31691588 Abstract Title:  Inhibiting effect of oleocanthal on neuroblastoma cancer cell proliferation in culture. Abstract:  We investigated the potential anticancer effects of oleocanthal (OC) on neuroblastoma cells. Cells were divided into four groups: group 1, neuroblastoma cells were treated with OC; group 2, neurons …

Oleocanthal and oleacein counteract inflammation-related gene and miRNA expression in adipocytes by attenuating NF-κB activation.

PMID:  Nutrients. 2019 Nov 21 ;11(12). Epub 2019 Nov 21. PMID: 31766503 Abstract Title:  The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation. Abstract:  Inflammation of the adipose tissue plays an important role in the development of several chronic diseases associated with obesity. Polyphenols …

The use of probiotics is beneficial in preventing radiation-induced diarrhea in patients receiving radiation therapy.

PMID:  Nutrients. 2019 Nov 27 ;11(12). Epub 2019 Nov 27. PMID: 31783578 Abstract Title:  The Effects of Probiotic Supplementation on the Incidence of Diarrhea in Cancer Patients Receiving Radiation Therapy: A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. Abstract:  The protective effects of probiotic supplementation against radiation-induced diarrhea (RID) have …

Vitamin E supplementation to hyperthyroid animals limits the thyroid hormone-induced increases in mitochondrial ROS and oxidative damage.

PMID:  Nutrients. 2019 Dec 1 ;11(12). Epub 2019 Dec 1. PMID: 31805673 Abstract Title:  Vitamin E Supplementation and Mitochondria in Experimental and Functional Hyperthyroidism: A Mini-Review. Abstract:  Mitochondria are both the main sites of production and the main target of reactive oxygen species (ROS). This can lead to mitochondrial dysfunction with harmful consequences for the …

Two case reports of stroke in children after varicella vaccination.

PMID:  J Pediatr. 2004 Dec ;145(6):845-7. PMID: 15580216 Abstract Title:  Stroke after varicella vaccination. Abstract:  Two children presented with acute hemiparesis 5 days and 3 weeks following varicella vaccination. Both showed unilateral infarction of the basal ganglia and internal capsule, a distribution consistent with varicella angiopathy. Both children had small patent foramen ovale (PFO), and …

A case report of ischaemic stroke following influenza A/H1N1 vaccination.

PMID:  Arch Med Sci. 2011 Apr ;7(2):345-8. Epub 2011 May 17. PMID: 22291779 Abstract Title:  Ischaemic stroke and influenza A H1N1 vaccination: a case report. Abstract:  We report a 75-year-old male patient who suffered posterior circulation ischaemia after influenza A/H1N1 vaccination. Vaccination provokes a variable magnitude of inflammatory and immunological response that modifies the risk …

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