PMID: Int J Med Sci. 2017 ;14(12):1284-1291. Epub 2017 Sep 30. PMID: 29104486 Abstract Title: Tanshinone IIA Inhibitsβ-Catenin Nuclear Translocation and IGF-2R Activation via Estrogen Receptors to Suppress Angiotensin II-Induced H9c2 Cardiomyoblast Cell Apoptosis. Abstract: Cardiomyopathy involves changes in the myocardial ultra-structure, hypertrophy, apoptosis, fibrosis and inflammation. Angiotensin II (AngII) stimulates the expression of insulin …
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Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test.
PMID: Pharm Biol. 2017 Dec ;55(1):2264-2269. PMID: 29171356 Abstract Title: Antifatigue properties of tanshinone IIA in mice subjected to the forced swimming test. Abstract: CONTEXT: Tanshinone IIA (Tan IIA) is a constituent of Danshen Salvia miltiorrhiza Bunge (Lamiaceae); however, its antifatigue activity remains unclear.OBJECTIVE: To study the antifatigue properties of Tan IIA and its underlying …
Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.
PMID: Mol Med Rep. 2018 Feb ;17(2):2384-2392. Epub 2017 Nov 24. PMID: 29207086 Abstract Title: Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway. Abstract: Tanshinone IIA (Tan IIA), as a bioactive compound extracted from the dried roots of Salvia miltiorrhiza (also known as Danshen), is known to inhibit cancer cell proliferation and …
Continue reading “Tan IIA inhibits H1299 cell viability through the MDM4‑IAP3 signaling pathway.”
Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver.
PMID: Exp Ther Med. 2017 Nov ;14(5):4639-4646. Epub 2017 Sep 21. PMID: 29201162 Abstract Title: Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver. Abstract: Oxidative stress is a crucial factor associated with fatty liver disease, which raises the possibility of using antioxidants to improve liver steatosis. Tanshinone …
Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway.
PMID: Mol Med Rep. 2018 Aug ;18(2):1899-1908. Epub 2018 Jun 26. PMID: 29956801 Abstract Title: Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR‑4‑mediated NF‑κB signal pathway. Abstract: Hypoxic ischemic encephalopathy (HIE) is the most common brain injury following hypoxia and/or ischemia caused by various factors during the perinatal period, resulting in detrimental neurological deficits in …
Tanshinone IIA attenuates paraquat‑induced acute lung injury.
PMID: Mol Med Rep. 2018 Sep ;18(3):2955-2962. Epub 2018 Jul 16. PMID: 30015919 Abstract Title: Tanshinone IIA attenuates paraquat‑induced acute lung injury by modulating angiotensin‑converting enzyme 2/angiotensin‑(1‑7) in rats. Abstract: Tanshinone IIA (TIIA) is an active compound that can be isolated from the Chinese herb, Salvia miltiorrhizae Bunge, also known as danshen. Previous studies have demonstrated …
Continue reading “Tanshinone IIA attenuates paraquat‑induced acute lung injury.”
Tanshinone IIA pretreatment protects H9c2 cells against anoxia/reoxygenation injury
PMID: Oxid Med Cell Longev. 2018 ;2018:3583921. Epub 2018 Jun 28. PMID: 30050654 Abstract Title: Tanshinone IIA Pretreatment Protects H9c2 Cells against Anoxia/Reoxygenation Injury: Involvement of the Translocation of Bcl-2 to Mitochondria Mediated by 14-3-3. Abstract: Tanshinone IIA is an important component that is isolated from danshen (), which is known to be beneficial for …
Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1.
PMID: Eur J Pharmacol. 2019 Aug 15 ;857:172419. Epub 2019 May 25. PMID: 31136758 Abstract Title: Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1. Abstract: Advanced glycation end products (AGEs) play an important role in the onset of diabetic retinopathy. Therefore, in the current study, we investigate whether …
Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure.
PMID: Acta Cir Bras. 2019 ;34(8):e201900807. Epub 2019 Oct 14. PMID: 31618407 Abstract Title: Mitigating effect of tanshinone IIA on ventricular remodeling in rats with pressure overload-induced heart failure. Abstract: PURPOSE: To investigate the effect of tanshinone IIA (TIIA) on ventricular remodeling in rats with pressure overload-induced heart failure.METHODS: Pressure overload-induced heart failure model (abdominal …
Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells.
PMID: Oncol Lett. 2019 Dec ;18(6):6554-6562. Epub 2019 Nov 1. PMID: 31807174 Abstract Title: Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway. Abstract: Epithelial-to-mesenchymal transition (EMT) is an essential phenotypic conversion involved in cancer progression. Epidermal growth factor (EGF) and transforming growth factor (TGF)-β1 are potent inducers …
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