This study highlights the importance of exposure to pesticides as an environmental risk factor for the development of breast cancer among women.

PMID:  Int J Environ Res Public Health. 2019 Oct 17 ;16(20). Epub 2019 Oct 17. PMID: 31627286 Abstract Title:  Environmental Exposure to Pesticides and Breast Cancer in a Region of Intensive Agribusiness Activity in Brazil: A Case-Control Study. Abstract:  : Breast cancer is a serious public health problem and is the second most prevalent cancer …

Early prenatal exposure to DDT may affect fetal BRCA1 gene methylation.

PMID:  Life Sci. 2018 May 1 ;200:81-86. Epub 2018 Mar 15. PMID: 29551577 Abstract Title:  Association of prenatal organochlorine pesticide-dichlorodiphenyltrichloroethane exposure with fetal genome-wide DNA methylation. Abstract:  AIMS: To investigate whether intrauterine organochlorine pesticide (OCP)-dichlorodiphenyltrichloroethane (DDT) exposure could lead to epigenetic alterations by DNA methylation with possible important lifetime health consequences for offspring.MAIN METHODS: We …

Oxidative phosphorylation impairment by DDT and DDE.

PMID:  Front Endocrinol (Lausanne). 2019 ;10:122. Epub 2019 Mar 12. PMID: 30915030 Abstract Title:  Oxidative Phosphorylation Impairment by DDT and DDE. Abstract:  There is increasing evidence supporting the characterization of the pesticide DDT and its metabolite, DDE, as obesogens and metabolic disruptors. Elucidating the mechanism is critical to understanding whether the association of DDT and …

DDE exposure at concentrations relevant to human exposure accelerates mammary carcinogenesis in mice.

PMID:  Environ Health Perspect. 2012 Aug ;120(8):1170-6. Epub 2012 Apr 18. PMID: 22514210 Abstract Title:  Accelerated mammary tumor onset in a HER2/Neu mouse model exposed to DDT metabolites locally delivered to the mammary gland. Abstract:  BACKGROUND: The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are …

Serum levels of organochlorine pesticides and breast cancer risk in Iranian women.

PMID:  Arch Environ Contam Toxicol. 2019 Nov ;77(4):480-489. Epub 2019 Jul 19. PMID: 31324944 Abstract Title:  Serum levels of Organochlorine Pesticides and Breast Cancer Risk in Iranian Women. Abstract:  Breast cancer is a multifactorial disease and its etiology is linked to multiple risk factors. There are shreds of controversial evidence that exposure to organochlorine pesticides …

DDT exposure in early childhood could raise the risk of breast cancer in adulthood.

PMID:  Environ Int. 2018 12 ;121(Pt 2):1106-1112. Epub 2018 Oct 28. PMID: 30376997 Abstract Title:  DDT exposure in early childhood and female breast cancer: Evidence from an ecological study in Taiwan. Abstract:  Researchers still lack consensus on the association between exposure to DDT and the risk of breast cancer. One reason could be that the …

Expression of the miR-190 family is increased under DDT exposure in vivo and in vitro.

PMID:  Mol Biol Rep. 2018 Dec ;45(6):1937-1945. Epub 2018 Nov 12. PMID: 30421125 Abstract Title:  Expression of the miR-190 family is increased under DDT exposure in vivo and in vitro. Abstract:  A non-genotoxic insecticide dichlorodiphenyltrichloroethane (DDT), can affect mRNA and microRNA levels, however, its precise mechanism of action remains poorly understood. Using in silico methods …

Fluoride induces autoimmune orchitis involved with enhanced IL-17A secretion in mice testis.

PMID:  J Agric Food Chem. 2019 Nov 8. Epub 2019 Nov 8. PMID: 31703480 Abstract Title:  Fluoride induces autoimmune orchitis involved with enhanced IL-17A secretion in mice testis. Abstract:  Fluoride (F) widely exists in the water and food. Recent studies reported that F induced testicular toxicity via inflammation reaction. This study was aimed to explore …

Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure.

PMID:  Dev Biol. 2019 01 15 ;445(2):280-293. Epub 2018 Nov 27. PMID: 30500333 Abstract Title:  Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure. Abstract:  Epigenetic alterations in the germline can be triggered by a number of different environmental factors from diet to toxicants. These environmentally induced germline changes can promote the …

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