PMID: Molecules. 2012 Apr 20 ;17(4):4672-83. Epub 2012 Apr 20. PMID: 22522397 Abstract Title: Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats. Abstract: The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. …
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Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis.
PMID: J Ethnopharmacol. 2013 Mar 27 ;146(2):543-51. Epub 2013 Jan 26. PMID: 23357312 Abstract Title: Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-κB pathway. Abstract: Paeonol is an active compound isolated from traditional Chinese medicine, and has been shown to have anti-atherosclerosis, anti-inflammatory, antioxidant effects. The present investigation was undertaken …
Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock.
PMID: Fundam Clin Pharmacol. 2014 Jun ;28(3):268-76. Epub 2013 Feb 17. PMID: 23413967 Abstract Title: Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock. Abstract: Paeonol (2'-hydroxy-4'-methoxyacetophenone) is the main phenolic compound of the radix of Paeonia suffruticosa which has been used as traditional Chinese medicine. In this study, …
Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells.
PMID: J Gastroenterol Hepatol. 2013 Jul ;28(7):1223-33. PMID: 23425217 Abstract Title: Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-κB pathway in activated stellate cells: in vivo and in vitro studies. Abstract: BACKGROUND AND AIMS: Hepatic fibrosis represents a major cause of morbidity and mortality worldwide. The present study was to evaluate the antifibrogenesis effect of …
Paeonol induces apoptosis in human ovarian cancer cells.
PMID: Acta Histochem. 2013 Oct ;115(8):835-9. Epub 2013 Jun 13. PMID: 23768958 Abstract Title: Paeonol induces apoptosis in human ovarian cancer cells. Abstract: Paeonol is a broad-spectrum antitumor agent, which is widely used in the treatment of various tumors in Asia. However, the effect of paeonol on ovarian cancer remains unclear. The purpose of this …
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These findings indicated paeonol might act as a beneficial agent for the prevention and treatment of diabetic encephalopathy.
PMID: Neurosci Lett. 2013 Aug 9 ;549:63-8. Epub 2013 Jun 19. PMID: 23791853 Abstract Title: Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Abstract: Diabetic encephalopathy (DE) has been characterized by the impaired cognition and the abnormalities of neurochemistry and neurostructure. The study was conducted to evaluate the neuroprotective …
Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation.
PMID: Neural Regen Res. 2013 Jun 25 ;8(18):1637-43. PMID: 25206460 Abstract Title: Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation. Abstract: Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional …
Continue reading “Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation.”
Paeonol attenuates Cisplatin-induced nephrotoxicity in mice.
PMID: Evid Based Complement Alternat Med. 2013 ;2013:310989. Epub 2013 Sep 19. PMID: 24171038 Abstract Title: Paeonol, a major compound of moutan cortex, attenuates Cisplatin-induced nephrotoxicity in mice. Abstract: Cisplatin is an effective chemotherapeutic agent that is used for the treatment of a variety of cancers; however, its nephrotoxicity limits the use of this drug. …
Continue reading “Paeonol attenuates Cisplatin-induced nephrotoxicity in mice.”
Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury.
PMID: Acta Pharmacol Sin. 2014 Apr ;35(4):483-8. Epub 2014 Feb 24. PMID: 24562307 Abstract Title: Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release. Abstract: AIM: Paeonol (2'-hydroxy-4'-methoxyacetophenone) from Cortex moutan root is a potential therapeutic agent for atherosclerosis. This study sought to investigate the mechanisms …
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These results suggested that paeonol might have a protective potential on gingival tissue inflammation and alveolar bone loss during the process of periodontitis.
PMID: Am J Chin Med. 2014 ;42(2):361-74. PMID: 24707868 Abstract Title: Effect of paeonol on tissue destruction in experimental periodontitis of rats. Abstract: We evaluated the effects of paeonol, a phenolic compound of Moutan Cortex, on the tissue inflammation and destruction in experimental periodontitis of rats. The maxillary palatal bony surfaces of 18 rats received …
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