PMID: Anticancer Res. 2019 Nov ;39(11):6115-6123. PMID: 31704839 Abstract Title: Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression. Abstract: BACKGROUND/AIM: Colon cancer is the second most common deadliest malignancy in the world and better understanding of its underlying mechanisms is needed to improve clinical management. Natural plant extracts are gaining attention …
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Paeonol could inhibit IL-1beta and TNF-alpha expression to protect vascular endothelial cells from being injured by lipopolysaccharide.
PMID: Zhongguo Zhong Yao Za Zhi. 2014 Mar ;39(6):1058-63. PMID: 24956851 Abstract Title: [Effect of paeonol on adhesive function of rat vascular endothelial cells induced by lipopolysaccharide and co-cultured with smooth muscle cells]. Abstract: OBJECTIVE: To observe the changes in the adhesive function of vascular endothelial cells (VEC) and rat monocytes induced by lipopolysaccharide (LPS) …
Antitumor and apoptosis induction effects of paeonol on mice bearing EMT6 breast carcinoma.
PMID: Biomol Ther (Seoul). 2014 Jul ;22(4):341-6. PMID: 25143814 Abstract Title: Antitumor and Apoptosis Induction Effects of Paeonol on Mice Bearing EMT6 Breast Carcinoma. Abstract: Paeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This …
Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling.
PMID: Mediators Inflamm. 2014 ;2014:651890. Epub 2014 Aug 3. PMID: 25165413 Abstract Title: Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling. Abstract: Cigarette smoking causes persistent lung inflammation that is mainly regulated by redox-sensitive pathways. We have previously reported that cigarette smoke (CS) activates reactive oxygen species- (ROS-) sensitive mitogen-activated protein kinases …
Paeonol attenuates advanced oxidation protein product-induced oxidative stress injury in THP-1 macrophages.
PMID: Pharmacology. 2014 ;93(5-6):286-95. Epub 2014 Aug 21. PMID: 25170865 Abstract Title: Paeonol attenuates advanced oxidation protein product-induced oxidative stress injury in THP-1 macrophages. Abstract: BACKGROUND: Paeonol (2'-hydroxy-4'-methoxyacetophenone) is thought to possess a broad range of clinically curative effects that are likely mediated by its anti-inflammatory and antioxidant activities.AIMS: To elucidate the efficacy of paeonol's …
Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines.
PMID: Food Sci Nutr. 2019 Sep ;7(9):2948-2957. Epub 2019 Aug 2. PMID: 31572588 Abstract Title: Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines. Abstract: Grape pomace is the source of bioactive compounds (anthocyanins, flavonols, flavan-3-ols, and stilbenes) which exhibit antiproliferative actions on cell cultures. We have investigated …
Grape seed extract may be useful for treating irritable bowel syndrome.
PMID: Nutrients. 2019 Nov 4 ;11(11). Epub 2019 Nov 4. PMID: 31689935 Abstract Title: Grape Seed Extract Eliminates Visceral Allodynia and Colonic Hyperpermeability Induced by Repeated Water Avoidance Stress in Rats. Abstract: Grape seed extract (GSE) is rich in polyphenols composed mainly of proanthocyanidins, which are known to attenuate proinflammatory cytokine production. Repeated water avoidance …
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Grape seed proanthocyanidin extract mitigates titanium dioxide nanoparticle-induced hepatotoxicity.
PMID: Biol Trace Elem Res. 2019 Nov 7. Epub 2019 Nov 7. PMID: 31701464 Abstract Title: Grape Seed Proanthocyanidin Extract Mitigates Titanium Dioxide Nanoparticle (TiO-NPs)-Induced Hepatotoxicity Through TLR-4/NF-κB Signaling Pathway. Abstract: With the progress of nanotechnology, the adverse effects of nanoscale materials are receiving much attention. Inhibition of toll-like receptor 4 (TLR-4)/nuclear factor kappa B …
Paeonol pretreatment attenuates cerebral ischemic injury.
PMID: Brain Res Bull. 2014 Oct ;109:61-7. Epub 2014 Oct 5. PMID: 25286445 Abstract Title: Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice. Abstract: BACKGROUND: Oxidative damage plays a pivotal role in the pathogenesis of cerebral ischemic stroke and may represent a target for …
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Paeonol reversed paclitaxel resistance in MCF-7/PTX cells by downregulating the activity of the SET/PP2A/Akt pathway.
PMID: Mol Med Rep. 2015 Jul ;12(1):1506-14. Epub 2015 Mar 11. PMID: 25760096 Abstract Title: Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway. Abstract: Breast cancer is one of the most prevalent types of malignant tumor. Paclitaxel is widely used in the treatment of breast cancer; however, …
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