PMID: Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015 Jan ;44(1):30-6. PMID: 25851972 Abstract Title: [Neuroprotective effects of paeonol in a cell model of Parkinson disease]. Abstract: OBJECTIVE: To investigate the effects of paeonol on neuron cell model of Parkinson disease (PD).METHODS: The cell model of Parkinson disease was induced by treatment of 1-Methyl-4-phenylpyridinium …
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For years, scientists have warned about the dangers of enormous amounts of debris orbiting our planet. Now, telecommunications companies want to 20,000 more satellites to the growing orbit of junk
PMID: Inflammation. 2016 Feb ;39(1):434-446. PMID: 26433578 Abstract Title: Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking MAPK/ERK/p38 Signaling Pathway. Abstract: The possible protective and curative effects of paeonol on carrageenan-induced acute hind paw edema in rats and dextran sulfate sodium (DSS)-induced colitis in mice have been evaluated. After oral administration, paeonol …
PMID: IUBMB Life. 2015 Oct ;67(10):778-88. Epub 2015 Oct 10. PMID: 26452780 Abstract Title: Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo via disrupting proinflammatory cytokines-mediated NF-κB and STAT3 pathways. Abstract: Cancer related inflammation (CRI) is now recognized as the seventh hallmark in the pathogenesis of many types of malignancies. Paeonol, a natural …
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PMID: Front Pharmacol. 2019 ;10:1059. Epub 2019 Sep 19. PMID: 31607915 Abstract Title: Black Walnut () Extracts Inhibit Proinflammatory Cytokine Production From Lipopolysaccharide-Stimulated Human Promonocytic Cell Line U-937. Abstract: Black walnut (L.) is an excellent source of health-promoting compounds. Consumption of black walnuts has been linked to many health benefits (e.g., anti-inflammatory) stemming from its …
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PMID: Chem Biol Interact. 2016 Jan 25 ;244:1-8. Epub 2015 Dec 2. PMID: 26646421 Abstract Title: The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway. Abstract: Epirubicin is widely used for the treatment of various breast cancers; however, it has serious adverse side effects, such as …
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PMID: Zhongguo Zhong Yao Za Zhi. 2015 Dec ;40(24):4903-7. PMID: 27245041 Abstract Title: [Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion]. Abstract: Previous studies have shown that paeonol can antagonize acute myocardial ischemia and infarction in rat. This study further researched the …
PMID: PLoS One. 2016 ;11(5):e0154375. Epub 2016 May 4. PMID: 27144271 Abstract Title: Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice. Abstract: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced acute liver failure. The purpose of this study was to investigate whether paeonol protected against APAP-induced hepatotoxicity. Mice treated with …
PMID: Psychiatry Res. 2016 Apr 30 ;238:116-121. Epub 2016 Feb 17. PMID: 27086220 Abstract Title: Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice. Abstract: The present study was designed to detect the anti-depressant effects of paeonol and the possible mechanisms in the lipopolysaccharide-induced depressive-like behavior. Open-field test(OFT), tail suspension test(TST) and forced swimming test(FST) were used …
PMID: Inflammation. 2016 Dec ;39(6):1904-1917. PMID: 27624059 Abstract Title: Paeonol Suppresses Neuroinflammatory Responses in LPS-Activated Microglia Cells. Abstract: In this work, we assessed the anti-inflammatory effects of paeonol (PAE) in LPS-activated N9 microglia cells, as well as its underlying molecular mechanisms. PAE had no adverse effect on the viability of murine microglia N9 cell line …
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