PMID: Tumour Biol. 2016 Sep ;37(9):12301-12313. Epub 2016 Jun 7. PMID: 27272157 Abstract Title: Enhanced antitumor activity and attenuated cardiotoxicity of Epirubicin combined with Paeonol against breast cancer. Abstract: Epirubicin is widely used for the therapy of various breast cancers. However, it has serious adverse side effects, particularly cardiotoxicity, which can cause irreversible damage in …
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These results indicated that paeonol has protective effects on endotoxin-induced kidney injury.
PMID: Oncotarget. 2016 Jun 28 ;7(26):39497-39510. PMID: 27027358 Abstract Title: Paeonol protects endotoxin-induced acute kidney injury: potential mechanism of inhibiting TLR4-NF-κB signal pathway. Abstract: STUDY DESIGN AND METHODS: In order to determine the therapeutic effect and mechanism of paeonol on acute kidney injury induced by endotoxin, an acute kidney injury model was established by intraperitoneal …
Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways.
PMID: Eur J Pharmacol. 2017 Jan 15 ;795:84-93. Epub 2016 Dec 6. PMID: 27940053 Abstract Title: Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-κB pathways. Abstract: Renal injury is a dose-dependent side effect of epirubicin that limits its clinical application in the field of tumor chemotherapy. Paeonol is an active ingredient …
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
PMID: Int Immunopharmacol. 2017 May ;46:124-132. Epub 2017 Mar 7. PMID: 28282576 Abstract Title: Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice. Abstract: To evaluate the hepatoprotective effects and potential mechanisms of paeonol (Pae) against acute liver failure (ALF) induced by lipopolysaccharide (LPS)/d-galactosamine (d-GalN) in mice, we examined anti-oxidative, anti-inflammatory …
Paeonol may be a potent therapeutic treatment for psoriasis.
PMID: Int J Mol Med. 2017 May ;39(5):1101-1110. Epub 2017 Mar 21. PMID: 28339016 Abstract Title: Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells. Abstract: Paeonol, an active component derived from the traditional Chinese medicine Cortex Moutan, possesses anti-inflammatory, analgesic, antioxidant and anti-allergic properties. Psoriasis is …
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Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes.
PMID: Inflamm Res. 2017 Jul ;66(7):603-610. Epub 2017 Apr 11. PMID: 28401267 Abstract Title: Paeonol protects against TNF-α-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression. Abstract: BACKGROUND: Fibroblast-like synoviocytes (FLS) play an essential role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis. …
Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by paeonol.
PMID: Front Physiol. 2017 ;8:193. Epub 2017 Mar 31. PMID: 28408888 Abstract Title: Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol. Abstract: Pulmonary fibrosis is a severe and progressive disease that is characterized by an abnormal deposition of extracellular matrix, such as collagens. The pathogenesis of this disease may be initiated by …
Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase.
PMID: Oncotarget. 2017 Apr 18 ;8(16):27093-27104. PMID: 28404919 Abstract Title: Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase. Abstract: Excessive exposure to solar UV (SUV) is related with numerous human skin disorders, such as skin inflammation, photoaging and carcinogenesis. T-LAK cell- originated protein kinase (TOPK), an upstream of p38 mitogen-activated protein …
Chronic treatment with paeonol improves endothelial function in mice.
PMID: PLoS One. 2017 ;12(5):e0178365. Epub 2017 May 31. PMID: 28562691 Abstract Title: Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress. Abstract: Endoplasmic reticulum (ER) stress leads to endothelial dysfunction which is commonly associated in the pathogenesis of several cardiovascular diseases. We explored the vascular protective …
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Paeonol inhibited the excretion of the inflammatory factors by P. gingivalis-induced bone marrow-derived macrophage in a dose-dependent manner.
PMID: Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr 1 ;35(2):139-144. PMID: 28682542 Abstract Title: [Effects of paeonol on the function of bone marrow-derived macrophage from Porphyromonas gingivalis-induced mice]. Abstract: OBJECTIVE: This work aims to examine the effects of paeonol treatment on the ability of bone marrow-derived macrophage (BMM) to excrete inflammatory factors …
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