Category Archives: Uncategorized

PMID:  Inflammation. 2017 Oct ;40(5):1698-1706. PMID: 28695367 Abstract Title:  Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies. Abstract:  Paeonol, the main active component isolated from the root of Paeonia suffruticosa, has been reported to have anti-inflammatory properties. However, the effects of paeonol on osteoarthritis (OA) remain unclear. The aim of this …

Continue reading “Paeonol may be a potential therapeutic agent in the treatment of osteoarthritis.”

PMID:  Inflammopharmacology. 2017 Aug 10. Epub 2017 Aug 10. PMID: 28799079 Abstract Title:  Protective effects of paeonol on inflammatory response in IL-1β-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-κB pathway. Abstract:  Various investigations have demonstrated that human fibroblast-like synoviocytes rheumatoid arthritis (HFLS-RA) take part in the chronic inflammatory responses and RA progression. …

Continue reading “These collective results indicated that paeonol might be a promising therapeutic agent for alleviating rheumatoid arthritis progress.”

PMID:  Biomed Pharmacother. 2017 Nov ;95:914-921. Epub 2017 Sep 10. PMID: 28910961 Abstract Title:  Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis. Abstract:  Interleukin-1β (IL-1β)-induced inflammatory responses in chondrocytes play an important role in the pathogenesis of osteoarthritis (OA). Searching medicines that affect IL-1β-mediated chondrocytes function is critical in developing therapies for OA. Paeonol, …

Continue reading “Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis.”

PMID:  Exp Ther Med. 2017 Oct ;14(4):3213-3220. Epub 2017 Aug 3. PMID: 28912871 Abstract Title:  Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor. Abstract:  Radiotherapy is a vital and effective method to treat solid …

Continue reading “Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis.”

PMID:  Int J Nanomedicine. 2017 ;12:6605-6616. Epub 2017 Sep 7. PMID: 28924345 Abstract Title:  Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects. Abstract:  Paeonol (Pae; 2'-hydroxy-4'-methoxyacetophenone) has attracted intense attention as a potential therapeutic agent against various cancers. However, the use of Pae is limited owing to its hydrophobicity. …

Continue reading “Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects.”

PMID:  Chem Biol Interact. 2018 Apr 25 ;286:17-25. Epub 2018 Mar 2. PMID: 29505745 Abstract Title:  Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway. Abstract:  Cardiotoxicity is a dose-dependent side effect of epirubicin that restricts its clinical utility in cancer chemotherapy. Paeonol is an active constituent with various biological …

Continue reading “Cardioprotective effect of paeonol against epirubicin-induced heart injury.”

PMID:  Mol Med Rep. 2017 Nov ;16(5):7513-7519. Epub 2017 Sep 21. PMID: 28944890 Abstract Title:  Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Abstract:  Paeonol (Pae) is an herbal extract that has attracted extensive attention for its anti‑cancer effects demonstrated by …

Continue reading “Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells.”

PMID:  J Ethnopharmacol. 2019 Nov 7:112325. Epub 2019 Nov 7. PMID: 31707049 Abstract Title:  Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Zataria multiflora (Z. multiflora) belongs to the Lamiaceae family and has several traditional uses owing to …

Continue reading “Z. multiflora reduced inflammation and improved pulmonary function tests indices in sulfur mustard-exposed patients.”

PMID:  Med Sci Monit. 2017 Oct 3 ;23:4740-4748. Epub 2017 Oct 3. PMID: 28972959 Abstract Title:  Role of Paeonol in an Astrocyte Model of Parkinson's Disease. Abstract:  BACKGROUND Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Inflammation and neural degeneration are implicated in …

Continue reading “Role of paeonol in an astrocyte model of Parkinson’s disease.”

PMID:  J Pharmacol Exp Ther. 2018 03 ;364(3):420-432. Epub 2017 Dec 19. PMID: 29259041 Abstract Title:  Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. Abstract:  Inflammatory injury of the endothelium leads to apoptosis and endothelial dysfunction. The current study explored the effect and mechanisms of paeonol in …

Continue reading “Paeonol reduces lipopolysaccharide-induced endothelial dysfunction and apoptosis.”