PMID: Front Pharmacol. 2017 ;8:948. Epub 2018 Jan 4. PMID: 29354055 Abstract Title: The Anti-atherosclerotic Effect of Paeonol against Vascular Smooth Muscle Cell Proliferation by Up-regulation of Autophagy via the AMPK/mTOR Signaling Pathway. Abstract: Paeonol (2'-hydroxy-4'-methoxyacetophenone), isolated from moutan cortex, is an active component and has been shown to have anti-atherosclerotic and anti-proliferation effects on …
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Paeonol may be one of promising candidate for the treatment of atherosclerosis.
PMID: Front Pharmacol. 2018 ;9:95. Epub 2018 Feb 8. PMID: 29472864 Abstract Title: Paeonol Inhibits Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cells Autophagy by Upregulating the Expression of miRNA-30a. Abstract: Paeonol from Cortex Moutan root is a potential therapeutic agent for atherosclerosis (AS). However, its mechanisms of action are still not fully understood. Vascular endothelial cells …
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These results indicate that paeonol may has the potential to improve learning and memory in Alzheimer’s disease.
PMID: Eur J Pharmacol. 2018 May 15 ;827:227-237. Epub 2018 Mar 15. PMID: 29550337 Abstract Title: Paeonol promotes hippocampal synaptic transmission: The role of the Kv2.1 potassium channel. Abstract: Paeonol is a major constituent of the Chinese herb Moutan cortex radices. Recent studies report that paeonol has neuroprotective effects and improves impaired learning and memory. …
Protective effects of paeonol on subacute/chronic brain injury during cerebral ischemia.
PMID: Exp Ther Med. 2018 Apr ;15(4):3836-3846. Epub 2018 Feb 26. PMID: 29563983 Abstract Title: Protective effects of paeonol on subacute/chronic brain injury during cerebral ischemia in rats. Abstract: Ischemic stroke is a highly complex pathological process that is divided into acute, subacute and chronic phases. Paeonol is a biologically active natural product with a …
Paeonol alleviated acute alcohol-induced liver injury.
PMID: Environ Toxicol Pharmacol. 2018 Jun ;60:110-117. Epub 2018 Apr 22. PMID: 29704732 Abstract Title: Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-κB signaling pathway. Abstract: In this study, the beneficial effect of paeonol on acute alcohol-induced liver injury and the basic mechanisms were investigated. in vitro, HepG2 cells were treated with paeonol for 24 h …
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Paeonol attenuated chronic unpredictable mild stress-induced depression-like behaviours.
PMID: Psychopharmacology (Berl). 2018 Jul ;235(7):2177-2191. Epub 2018 May 12. PMID: 29752492 Abstract Title: Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats. Abstract: RATIONALE: Increasing evidence has suggested that major depressive disorder (MDD) is highly associated with brain-derived neurotrophic factor …
Paeonol a promising botanical in protecting skin from UVB-induced photoaging.
PMID: Phytother Res. 2018 Sep ;32(9):1741-1749. Epub 2018 May 10. PMID: 29748977 Abstract Title: Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway. Abstract: Paeonia suffruticosa Andr. (PS) has been used in traditional Chinese medicine for a long time. However, there are no studies that investigate the preventive effects …
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Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line.
PMID: Int J Mol Med. 2018 Sep ;42(3):1473-1483. Epub 2018 May 23. PMID: 29845222 Abstract Title: Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway. Abstract: The purpose of the present study was to analyze the association between paeonol and the known genes related …
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Paeonol delays the progression of diabetic renal fibrosis.
PMID: Front Pharmacol. 2018 ;9:512. Epub 2018 May 18. PMID: 29867511 Abstract Title: Paeonol Ameliorates Diabetic Renal Fibrosis Through Promoting the Activation of the Nrf2/ARE Pathway via Up-Regulating Sirt1. Abstract: Diabetic nephropathy (DN) is rapidly becoming the leading cause of end-stage renal disease worldwide and a major cause of morbidity and mortality in patients of …
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Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock.
PMID: Int Immunopharmacol. 2018 Aug ;61:169-177. Epub 2018 Jun 5. PMID: 29883962 Abstract Title: Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats. Abstract: High-mobility group box 1 (HMGB1) is a highly conserved DNA-binding nuclear protein that facilitates gene transcription and the DNA repair response. However, HMGB1 may be released by necrotic …
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