PMID: Molecules. 2018 Dec 5 ;23(12). Epub 2018 Dec 5. PMID: 30563087 Abstract Title: The Potential of South African Herbal Tisanes, Rooibos and Honeybush in the Management of Type 2 Diabetes Mellitus. Abstract: Diabetes mellitus is a metabolic disease that can lead to high morbidity, mortality and long-term complications. Available treatment strategies, which are mainly …
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Impact of cold versus hot brewing on the phenolic profile and antioxidant capacity of rooibos herbal tea.
PMID: Antioxidants (Basel). 2019 Oct 21 ;8(10). Epub 2019 Oct 21. PMID: 31640245 Abstract Title: Impact of Cold versus Hot Brewing on the Phenolic Profile and Antioxidant Capacity of Rooibos () Herbal Tea. Abstract: Consumption of rooibos () as herbal tea is growing in popularity worldwide and its health-promoting attributes are mainly ascribed to its …
These findings suggest that a green rooibos extract has potential as an anti-steatotic, anti-inflammatory and weight reducing agent in vivo.
PMID: Acta Histochem. 2019 Jul ;121(5):646-656. Epub 2019 May 29. PMID: 31153588 Abstract Title: A histomorphometric study on the hepatoprotective effects of a green rooibos extract in a diet-induced obese rat model. Abstract: Obesity, type two diabetes mellitus and insulin resistance are associated with increased oxidative stress and inflammation. Unfermented green rooibos is an aspalathin …
Rooibos suppresses proliferation of castration-resistant prostate cancer cells via inhibition of Akt signaling.
PMID: Phytomedicine. 2019 Aug 8 ;64:153068. Epub 2019 Aug 8. PMID: 31419729 Abstract Title: Rooibos suppresses proliferation of castration-resistant prostate cancer cells via inhibition of Akt signaling. Abstract: BACKGROUND: Androgen ablation therapy is the primary treatment for metastatic prostate cancer (PCa). However, the majority of PCa patients receiving the androgen deprivation therapy develop recurrent castration-resistant …
Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling.
PMID: Oncotarget. 2017 Oct 20 ;8(50):87401-87414. Epub 2017 Sep 18. PMID: 29152090 Abstract Title: saponins attenuate inflammationandby inhibition of NF-κB and STAT3 signaling. Abstract: Recent advances in the development of anti-inflammatory agents have improved their therapeutic outcome in inflammatory bowel disease (IBD), however, the presence of side effects and limited effectiveness hinder their widespread use. …
Gynostemma pentaphyllum attenuates the progression of nonalcoholic fatty liver disease.
PMID: Evid Based Complement Alternat Med. 2018 ;2018:8384631. Epub 2018 Mar 21. PMID: 29743925 Abstract Title: Attenuates the Progression of Nonalcoholic Fatty Liver Disease in Mice: A Biomedical Investigation Integrated with In Silico Assay. Abstract: Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in developed countries. Oxidative stress plays a …
Gypenosides improve diabetic cardiomyopathy by inhibiting ROS‐mediated NLRP3 inflammasome activation.
PMID: J Cell Mol Med. 2018 09 ;22(9):4437-4448. Epub 2018 Jul 11. PMID: 29993180 Abstract Title: Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation. Abstract: NLRP3 inflammasome activation plays an important role in diabetic cardiomyopathy (DCM), which may relate to excessive production of reactive oxygen species (ROS). Gypenosides (Gps), the major ingredients of …
Gypenosides altered hepatic bile acids homeostasis in mice treated with high fat diet.
PMID: Evid Based Complement Alternat Med. 2018 ;2018:8098059. Epub 2018 Jul 12. PMID: 30105069 Abstract Title: Gypenosides Altered Hepatic Bile Acids Homeostasis in Mice Treated with High Fat Diet. Abstract: Gypenosides extracted from(Thunb.) Makino have significant role in reducing serum lipid level and treating fatty liver diseases, however, without clear mechanism. As gypenosides share the …
Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation.
PMID: Biomed Pharmacother. 2018 Oct ;106:1153-1160. Epub 2018 Jul 18. PMID: 30119182 Abstract Title: Gypenosides reverses depressive behavior via inhibiting hippocampal neuroinflammation. Abstract: Gypenosides, a saponins extract isolated from the Gynostemma pentaphyllum plant, produces neuroprotective effects in the brain. Our previous studies have shown that hippocampal glucocorticoid receptor (GR)-brain-derived neurotrophic factor (BDNF)-TrkB signaling was involved …
Gypenoside UL4-rich Gynostemma pentaphyllum extract exerts a hepatoprotective effect on diet-induced nonalcoholic fatty liver disease.
PMID: Am J Chin Med. 2018 ;46(6):1315-1332. Epub 2018 Sep 5. PMID: 30180767 Abstract Title: Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease. Abstract: Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Gynostemma pentaphyllum extract (GPE) is proven to be …
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