PMID: Rev Epidemiol Sante Publique. 1992 ;40 Suppl 1:S55-62. PMID: 1626106 Abstract Title: Electromagnetic fields and cancer risks. Abstract: Cancer was first associated with exposure to electromagnetic fields (EMF) in 1979 when Wertheimer and Leeper reported that children dying from cancer resided more often in homes believed to be exposed to higher EMF than did …
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The current findings demonstrate that carnosine protects MPC5 cell against high glucose-induced apoptosis.
PMID: Biomed Res Int. 2019 ;2019:4348973. Epub 2019 May 28. PMID: 31275971 Abstract Title: Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways. Abstract: Diabetic nephropathy is the complication of diabetes mellitus that can lead to chronic renal failure. Reactive oxygen species (ROS) production plays an important role in its …
Carnosine has a promising potential for the treatment and prevention of different kidney diseases.
PMID: Curr Med Chem. 2019 Jul 30. Epub 2019 Jul 30. PMID: 31362685 Abstract Title: Carnosine and Kidney Diseases: What We Currently Know? Abstract: Carnosine (beta-alanyl-L-histidine) is an endogenously synthesised dipeptide which is present in different human tissues e.g. in the kidney. Carnosine is degraded by enzyme serum carnosinase, encoding by CNDP1 gene. Carnosine is …
L-arginine and carnosine combination could effectively protect against hypoxia-induced neurotoxicity.
PMID: Naunyn Schmiedebergs Arch Pharmacol. 2019 Oct 22. Epub 2019 Oct 22. PMID: 31641819 Abstract Title: Carnosine and L-arginine attenuate the downregulation of brain monoamines and gamma aminobutyric acid; reverse apoptosis and upregulate the expression of angiogenic factors in a model of hemic hypoxia in rats. Abstract: PURPOSE: The purpose of the present study was …
Carnosol could be explored as a potential dietary supplement to slow aging.
PMID: Oxid Med Cell Longev. 2019 ;2019:5958043. Epub 2019 Jun 24. PMID: 31341531 Abstract Title: Carnosol Improved Lifespan and Healthspan by Promoting Antioxidant Capacity in. Abstract: Carnosol, a phenolic diterpene, is one of the main constituents of. It is known to possess a range of bioactivities, including antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Nevertheless, the …
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Carnosol may represent a promising therapeutic candidate that canmodulate breast cancer growth and metastasis.
PMID: Front Oncol. 2019 ;9:743. Epub 2019 Aug 8. PMID: 31456939 Abstract Title: Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3. Abstract: We have previously demonstrated that carnosol, a naturally occurring diterpene, inhibitedcell viability and colony growth, as well as induced cell cycle …
Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control.
PMID: Eur J Pharm Sci. 2019 Sep 1 ;137:104988. Epub 2019 Jul 7. PMID: 31291598 Abstract Title: Piperine-loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control. Abstract: Piperine, an alkaloid from black pepper, has demonstrated beneficial effects in central nervous system, especially in epilepsy control. However, its therapeutic application remains limited due to …
Piperine can inhibit the transformation of endothelial cells into fibroblasts.
PMID: Zhonghua Xin Xue Guan Bing Za Zhi. 2019 Jul 24 ;47(7):554-560. PMID: 31365997 Abstract Title: [Piperine inhibits the transformation of endothelial cells into fibroblasts]. Abstract: To investigate the role of piperine on the transformation of endothelial cells into fibroblasts.Cultured human umbilical vein endothelial cells (HUVECs, 4-6 passage) were used for the main experiments. The …
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Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury.
PMID: Heliyon. 2019 Aug ;5(8):e02180. Epub 2019 Aug 13. PMID: 31463384 Abstract Title: Piperine pretreatment attenuates renal ischemia-reperfusion induced liver injury. Abstract: Background: Remote organ injury is one of the complications which are developed following ischemia-reperfusion induced acute kidney injury (AKI), dramatically increasing its mortality rate. The aim of the present study was to investigate …
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These findings suggest that piperine treatment ameliorates pancreatic fibrosis.
PMID: Mol Med Rep. 2019 Oct ;20(4):3709-3718. Epub 2019 Sep 2. PMID: 31485676 Abstract Title: Piperine ameliorates the severity of fibrosis via inhibition of TGF‑β/SMAD signaling in a mouse model of chronic pancreatitis. Abstract: Chronic pancreatitis (CP) is characterized by recurrent pancreatic injury, resulting in inflammation and fibrosis. Currently, there are no drugs for the …
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