PMID: Life Sci. 2019 Sep 1 ;232:116662. Epub 2019 Jul 16. PMID: 31323271 Abstract Title: Astragaloside IV protects against hyperglycemia-induced vascular endothelial dysfunction by inhibiting oxidative stress and Calpain-1 activation. Abstract: AIMS: Vascular endothelial cells act as a selective barrier between circulating blood and vessel wall and play an important role in the occurrence and …
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Astragaloside IV protects dopaminergic neuron from neuroinflammation and oxidative stress.
PMID: Int Immunopharmacol. 2019 Oct ;75:105651. Epub 2019 Aug 8. PMID: 31401385 Abstract Title: Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model. Abstract: Oxidative stress and neuroinflammation are the key and early events during the pathological process of Parkinson's disease (PD). Thus, …
Astragaloside-IV might alleviate ischemia reperfusion-induced apoptosis.
PMID: J Ethnopharmacol. 2019 Oct 19:112319. Epub 2019 Oct 19. PMID: 31639488 Abstract Title: Astragaloside IV alleviates ischemia reperfusion-induced apoptosis by inhibiting the activation of key factors in death receptor pathway and mitochondrial pathway. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Apoptosis plays an important role in cerebral ischemia-reperfusion injury and triggers a series of pathological changes which may …
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Astragaloside IV regulates NF-κB-mediated cellular senescence and apoptosis of hepatic stellate cells to suppress PDGF-BB-induced activation.
PMID: Exp Ther Med. 2019 Nov ;18(5):3741-3750. Epub 2019 Sep 25. PMID: 31641375 Abstract Title: Astragaloside IV regulates NF-κB-mediated cellular senescence and apoptosis of hepatic stellate cells to suppress PDGF-BB-induced activation. Abstract: Activated hepatic stellate cells (HSCs) are the principal effectors during hepatic fibrosis, which is characterized by the accumulation of extracellular matrix. Therefore, present …
Novel antioxidative activity of astaxanthin and its synergistic effect with vitamin E.
PMID: J Nutr Sci Vitaminol (Tokyo). 2019 ;65(Supplement):S109-S112. PMID: 31619607 Abstract Title: Novel Antioxidative Activity of Astaxanthin and Its Synergistic Effect with Vitamin E. Abstract: Astaxanthin (Asx) is known to be a potent quencher of singlet oxygen and an efficient scavenger of superoxide anion. However, the scavenging activity of Asx toward the hydroxyl radical was …
Saffron capsules may help reduce the symptoms of depression in patients who experience mild or moderate depression and are overweight.
PMID: J Clin Pharm Ther. 2019 Oct 10. Epub 2019 Oct 10. PMID: 31602695 Abstract Title: A placebo controlled randomized clinical trial of Crocus sativus L. (saffron) on depression and food craving among overweight women with mild to moderate depression. Abstract: WHAT IS KNOWN AND OBJECTIVE: Crocus sativus L., commonly known as saffron, has known …
Findings of this study demonstrated significant antiproliferative and antitumorigenic properties of saffron in osteosarcoma.
PMID: J Pharm Pharmacol. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31645086 Abstract Title: Pharmacological properties and therapeutic potential of saffron (Crocus sativus L.) in osteosarcoma. Abstract: OBJECTIVES: In this comprehensive study, we aimed to investigate pharmacological properties and therapeutic significance of saffron in osteosarcoma cancer cells.METHODS: Plant materials were obtained from Safranbolu district …
Crocetin may be used as a novel therapy for preventing fulminant hepatic failure.
PMID: Exp Ther Med. 2019 Nov ;18(5):3775-3782. Epub 2019 Sep 19. PMID: 31616509 Abstract Title: Crocetin protects against fulminant hepatic failure induced by lipopolysaccharide/D-galactosamine by decreasing apoptosis, inflammation and oxidative stress in a rat model. Abstract: Fulminant hepatic failure (FHF) is a clinical syndrome characterized by sudden and severe liver dysfunction. Apoptosis and inflammation are …
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Crocus sativus hydroalcoholic extract has beneficial effects on inflammatory and enzymatic indices resulting from alcohol use in kidney and liver.
PMID: J Inflamm Res. 2019 ;12:269-283. Epub 2019 Oct 8. PMID: 31632125 Abstract Title: Investigating the effect ofL. petal hydroalcoholic extract on inflammatory and enzymatic indices resulting from alcohol use in kidney and liver of male rats. Abstract: Background: Studies have shown that consumption of high levels of alcohol causes many negative effects on the …
Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone.
PMID: Physiol Behav. 2019 Oct 12 ;212:112699. Epub 2019 Oct 12. PMID: 31614158 Abstract Title: Antidepressant activity of crocin-I is associated with amelioration of neuroinflammation and attenuates oxidative damage induced by corticosterone in mice. Abstract: Depression is the leading cause of mental health-related disease globally, and it affects an estimated 300 million people worldwide. However, …
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