PMID: Naunyn Schmiedebergs Arch Pharmacol. 2019 Nov ;392(11):1383-1391. Epub 2019 Jun 24. PMID: 31236657 Abstract Title: Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Abstract: Oleuropein, as an olive leaf extract antioxidant polyphenol, has been reported to be a free radical scavenger. This study was done to investigate the effects of …
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Hydroxytyrosol and oleuropein inhibit migration and invasion of MDA-MB-231 triple-negative breast cancer cells.
PMID: Anticancer Agents Med Chem. 2019 Jul 21. Epub 2019 Jul 21. PMID: 31333142 Abstract Title: Hydroxytyrosol and Oleuropein Inhibit Migration and Invasion of MDA-MB-231 Triple-Negative Breast Cancer Cell via Induction of Autophagy. Abstract: BACKGROUND: Breast Cancer (BC) is the leading cause of cancer-related deaths among women. As such, novel chemotherapeutic agents are urgently needed, …
Hydroxytyrosol reduced the expression of NOX and inhibited the inflammatory response caused by Advanced oxidation protein products in chondrocytes.
PMID: Int J Mol Med. 2019 Oct ;44(4):1531-1540. Epub 2019 Aug 5. PMID: 31432093 Abstract Title: Hydroxytyrosol promotes autophagy by regulating SIRT1 against advanced oxidation protein product‑induced NADPH oxidase and inflammatory response. Abstract: Advanced oxidation protein products (AOPPs) can trigger NADPH oxidase (NOX) and lead to the production of reactive oxygen species (ROS) in the …
Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis.
PMID: Biofactors. 2019 Aug 27. Epub 2019 Aug 27. PMID: 31454114 Abstract Title: Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach. Abstract: Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid …
Hydroxytyrosol-enriched diet could serve as a beneficial therapeutic approach to attenuate ischemic stroke-associated damage.
PMID: Nutrients. 2019 Oct 11 ;11(10). Epub 2019 Oct 11. PMID: 31614692 Abstract Title: Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke. Abstract: Stroke is one of the leading causes of adult disability worldwide. After ischemic stroke, damaged tissue surrounding the irreversibly damaged core of the infarct, …
Hydroxytyrosol modulates adipocyte gene and miRNA expression under inflammatory condition.
PMID: Nutrients. 2019 Oct 17 ;11(10). Epub 2019 Oct 17. PMID: 31627295 Abstract Title: Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition. Abstract: Chronic inflammation of the adipose tissue (AT) is a major contributor to obesity-associated cardiometabolic complications. The olive oil polyphenol hydroxytyrosol (HT) contributes to Mediterranean diet cardiometabolic benefits through mechanisms still …
Administration of olive leaf and hydroxytyrosol extracts significantly improved the antioxidant state in asthma disease.
PMID: Drug Chem Toxicol. 2019 Oct 23:1-12. Epub 2019 Oct 23. PMID: 31645146 Abstract Title: Chemical composition, antioxidant activities, in an allergic asthma model, ofL. leaf extracts from Collo (Skikda, Algeria). Abstract: This study is an attempt to characterize the chemical composition and antioxidant activity of olive leaves variety (namely Bouricha variety) that is very …
Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy.
PMID: Drug Deliv Transl Res. 2019 Oct 21. Epub 2019 Oct 21. PMID: 31637677 Abstract Title: Gold nanoparticles attenuate albuminuria by inhibiting podocyte injury in a rat model of diabetic nephropathy. Abstract: Several recent studies have reported that gold nanoparticles (AuNPs) attenuate hyperglycemia in diabetic animal models without any observed side effects. The present study …
Gold nanoparticles potentiates N-acetylcysteine effects on neurochemicals alterations in rats after polymicrobial sepsis.
PMID: J Drug Target. 2019 Oct 17:1-9. Epub 2019 Oct 17. PMID: 31594390 Abstract Title: Gold nanoparticles potentiates N-acetylcysteine effects on neurochemicals alterations in rats after polymicrobial sepsis. Abstract: Herein, we report the effect of gold nanoparticles (AuNP) and n-acetylcysteine (NAC) isolated or in association as important anti-inflammatory and antioxidant compounds on brain dysfunction in …
There is a role for NAC treatment in the management of chronic bronchitis by reducing symptoms and exacerbations.
PMID: Adv Ther. 2019 Oct 9. Epub 2019 Oct 9. PMID: 31598901 Abstract Title: Effect of Orally Administered N-Acetylcysteine on Chronic Bronchitis: A Meta-analysis. Abstract: INTRODUCTION: The effect of N-acetylcysteine (NAC) treatment for patients with chronic bronchitis (CB) is controversial. To better understand the role of NAC in CB treatment, we performed a meta-analysis to …
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