PMID: Nutr Res Pract. 2019 Oct ;13(5):367-376. Epub 2019 Jun 12. PMID: 31583055 Abstract Title: Anti-diabetic effects of blue honeyberry on high-fed-diet-induced type II diabetic mouse. Abstract: BACKGROUND/OBJECTIVE: The blue honeysuckle berry (var.L.) is a small deciduous shrub belonging to the Caprifoliaceae family that is native to Russia, China, Japan, and Korea. The berry of …
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shikonin may promote periodontal tissue wound healing.
PMID: Molecules. 2019 Sep 30 ;24(19). Epub 2019 Sep 30. PMID: 31574951 Abstract Title: Biological Effects of Shikonin in Human Gingival Fibroblasts via ERK 1/2 Signaling Pathway. Abstract: Shikonin, an active ingredient of, exerts anti-inflammatory and antibacterial effects, and promotes wound healing. We investigated whether shikonin stimulated gingival tissue wound healing in human gingival fibroblasts …
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Shikonin attenuates sympathetic remodeling in chronic heart failure.
PMID: Biochem Biophys Res Commun. 2019 Oct 8. Epub 2019 Oct 8. PMID: 31604527 Abstract Title: Shikonin attenuates sympathetic remodeling in chronic heart failure mice via regulating miR-124. Abstract: AIMS: Shikonin is a naphthoquinone compound extracted from the root of Lithospermum with various pharmacological activities. Sympathetic neural remodeling greatly contributes to chronic heart failure. Growing …
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Shikonin is effective to ameliorate atherosclerosis in HHcy-ApoE-/- mice.
PMID: Acta Pharmacol Sin. 2019 Oct 13. Epub 2019 Oct 13. PMID: 31607752 Abstract Title: Shikonin attenuates hyperhomocysteinemia-induced CD4T cell inflammatory activation and atherosclerosis in ApoEmice by metabolic suppression. Abstract: T cell metabolic activation plays a crucial role in inflammation of atherosclerosis. Shikonin (SKN), a natural naphthoquinone with anti-inflammatory activity, has shown to exert cardioprotective …
Continue reading “Shikonin is effective to ameliorate atherosclerosis in HHcy-ApoE-/- mice.”
Shikonin suppresses progression and epithelial mesenchymal transition in hepatocellular carcinoma cells.
PMID: Cell Biol Int. 2019 Oct 16. Epub 2019 Oct 16. PMID: 31617643 Abstract Title: Shikonin suppresses progression and epithelial mesenchymal transition in hepatocellular carcinoma (HCC) cells via modulating miR-106b/SMAD7/TGF-β signaling pathway. Abstract: Shikonin is a natural naphthoquinone component with antioxidant and anti-tumor function and has been used for hepatocellular carcinoma (HCC) treatment. According to …
Sesamin can relieve clinical symptoms and pathological changes that caused by inflammatory impairment in patients with rheumatoid arthritis.
PMID: Phytother Res. 2019 Sep ;33(9):2421-2428. Epub 2019 Jul 15. PMID: 31309643 Abstract Title: A randomized, triple-blind, placebo-controlled clinical trial, evaluating the sesamin supplement effects on proteolytic enzymes, inflammatory markers, and clinical indices in women with rheumatoid arthritis. Abstract: Inflammation is one of the main characteristics of rheumatoid arthritis. Based on the antiinflammatory properties of …
Red clover extract had positive effect on bone health in healthy menopausal women.
PMID: Evid Based Complement Alternat Med. 2015 ;2015:689138. Epub 2015 Jul 21. PMID: 26265926 Abstract Title: Intake of Novel Red Clover Supplementation for 12 Weeks Improves Bone Status in Healthy Menopausal Women. Abstract: Objective. To investigate the effect by which daily consumption of a novel red clover (RC) extract influences bone health, inflammatory status, and …
A standardised extract of red clover isoflavones had a statistical and clinically significant benefit for treating hot flushes in menopausal women.
PMID: Phytomedicine. 2017 Jan 15 ;24:141-147. Epub 2016 Dec 12. PMID: 28160855 Abstract Title: Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Abstract: OBJECTIVE: To critically assess the evidence for a specific standardised extract of Trifolium pratense …
Combined red clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms.
PMID: PLoS One. 2017 ;12(6):e0176590. Epub 2017 Jun 7. PMID: 28591133 Abstract Title: Combined Red Clover isoflavones and probiotics potently reduce menopausal vasomotor symptoms. Abstract: BACKGROUND: Natural estrogen decline leads to vasomotor symptoms (VMS). Hormone therapy alleviates symptoms but increases cancer risk. Effective treatments against VMS with minimal cancer risks are needed. We investigate the …
These results suggest that formononetin promotes early fracture healing through angiogenesis activation in the early stage of fracture repair.
PMID: Int Immunopharmacol. 2009 Nov ;9(12):1357-65. Epub 2009 Aug 17. PMID: 19695348 Abstract Title: Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Abstract: Plant-derived phytoestrogens have bone protective effects, but the molecular mechanism behind these effects remains unclear. This study is aimed at fully characterizing the fracture …
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