PMID: J Sci Food Agric. 2019 Oct 23. Epub 2019 Oct 23. PMID: 31646650 Abstract Title: Pomegranate juice improves the cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: A randomized crossover trial. Abstract: BACKGROUND: Pomegranate has antioxidant, cardioprotective, and anti-inflammatory properties. We designed a crossover study, aimed to determine if consumption …
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Epigenetic signatures such as DNA methylation and histone modifications could be proposed as molecular biomarkers of BPA-induced prostate cancer progression.
PMID: Environ Pollut. 2019 Oct 2 ;255(Pt 2):113318. Epub 2019 Oct 2. PMID: 31610501 Abstract Title: Global and region-specific post-transcriptional and post-translational modifications of bisphenol A in human prostate cancer cells. Abstract: Bisphenol A (BPA), as synthetic monomer used in the production of polycarbonate plastic and epoxy resins, has endocrine disruptor properties and high risk …
Formononetin induces apoptosis in PC-3 prostate cancer cells.
PMID: Nutr Cancer. 2014 ;66(4):656-61. Epub 2014 Mar 25. PMID: 24666255 Abstract Title: Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Abstract: Formononetin (FN), a bioactive component extracted from the red clover (Trifolium pratense L.), has been long used for treating carcinomas in China. In …
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Formononetin mediates neuroprotection against cerebral ischemia/reperfusion.
PMID: J Neurol Sci. 2014 Sep 15 ;344(1-2):100-4. Epub 2014 Jun 22. PMID: 24996490 Abstract Title: Formononetin mediates neuroprotection against cerebral ischemia/reperfusion in rats via downregulation of the Bax/Bcl-2 ratio and upregulation PI3K/Akt signaling pathway. Abstract: Isoflavone formononetin is a typical phytoestrogen isolated from Chinese medical herb red clover. It has been reported that estrogens …
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Formononetin may be developed as an antioxidant treatment in diabetic retinopathy.
PMID: Eur Rev Med Pharmacol Sci. 2014 ;18(15):2191-7. PMID: 25070826 Abstract Title: Formononetin attenuates hydrogen peroxide (H2O2)-induced apoptosis and NF-κB activation in RGC-5 cells. Abstract: OBJECTIVES: Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). Several studies suggest that the oxidative stress plays a role in the pathogenesis …
Prenatal maternal exposure to BPA may lead to alterations in white matter microstructure in preschool aged children.
PMID: Environ Health. 2019 Oct 15 ;18(1):85. Epub 2019 Oct 15. PMID: 31615514 Abstract Title: Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children. Abstract: BACKGROUND: Bisphenol A (BPA) is commonly used in the manufacture of plastics and epoxy resins. In North America, over 90% of the population has …
High bisphenol A concentrations augment the invasiveness of tumor cells.
PMID: Toxicol In Vitro. 2019 Oct 17:104676. Epub 2019 Oct 17. PMID: 31629898 Abstract Title: High bisphenol A concentrations augment the invasiveness of tumor cells through Snail-1/Cx43/ERRγ-dependent epithelial-mesenchymal transition. Abstract: Bisphenol A (BPA) is commonly present in plastics used for food storage and preservation. The release of BPA from these products results in a permanent …
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NAC is an effective adjunct for preserving mitochondrial homeostasis and reducing remote effects of AKI in environments where BPA exposure is vulnerable.
PMID: Antioxidants (Basel). 2019 Oct 21 ;8(10). Epub 2019 Oct 21. PMID: 31640182 Abstract Title: N-Acetylcysteine Attenuates the Increasing Severity of Distant Organ Liver Dysfunction after Acute Kidney Injury in Rats Exposed to Bisphenol A. Abstract: Distant organ liver damage after acute kidney injury (AKI) remains a serious clinical setting with high mortality. This undesirable …
BPA exposure exert negative effects on oocyte retrieval and embryo implantation in women undergoing IVF.
PMID: Ecotoxicol Environ Saf. 2019 Oct 21 ;187:109816. Epub 2019 Oct 21. PMID: 31648075 Abstract Title: Urinary bisphenol A concentration is correlated with poorer oocyte retrieval and embryo implantation outcomes in patients with tubal factor infertility undergoing in vitro fertilisation. Abstract: Bisphenol A (BPA) is a substance ubiquitously present in the environment, and its toxicity …
Formononetin prevents ovariectomy-induced bone loss in rats.
PMID: Arch Pharm Res. 2010 Apr ;33(4):625-32. Epub 2010 Apr 27. PMID: 20422373 Abstract Title: Formononetin prevents ovariectomy-induced bone loss in rats. Abstract: The major risk factor of postmenopausal osteoporosis is estrogen deficiency. Hormone replacement therapy is efficacious against osteoporosis, but it induces several significant adverse effects. In this study, therefore, we compared therapeutic potencies …
Continue reading “Formononetin prevents ovariectomy-induced bone loss in rats.”
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