PMID: Int Immunopharmacol. 2011 Jan ;11(1):46-54. Epub 2010 Oct 16. PMID: 20959155 Abstract Title: Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways. Abstract: Formononetin, a phytoestrogen from the root of Astragalus membranaceus, is used as a blood enhancer and …
Continue reading “Formononetin promotes endothelial repair and wound healing.”
PMID: Horm Metab Res. 2011 Sep ;43(10):681-6. Epub 2011 Sep 19. PMID: 21932171 Abstract Title: Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Abstract: Formononetin is one of the main components of red clover plants, and is considered as a typical phytoestrogen. This study further …
PMID: Cells Tissues Organs. 2018 ;206(1-2):95-105. Epub 2019 Jan 31. PMID: 30703768 Abstract Title: The Effect of the Prethanol Extract of Trifolium pratense Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes. Abstract: BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a …
PMID: Phytother Res. 2012 Jun ;26(6):860-4. Epub 2011 Nov 14. PMID: 22084061 Abstract Title: Red clover extract ameliorates dyslipidemia in streptozotocin-induced diabetic C57BL/6 mice by activating hepatic PPARα. Abstract: The effects of red clover extract and its bioactive components, biochanin A and formononetin, on the blood glucose and lipid levels of streptozotocin (STZ) induced-diabetic mice …
PMID: J Alzheimers Dis. 2012 ;28(4):795-808. PMID: 22085862 Abstract Title: Formononetin protects neurons against hypoxia-induced cytotoxicity through upregulation of ADAM10 and sAβPPα. Abstract: Formononetin, an active constituent of the Chinese herb Astragali Radix, has been reported to have beneficial effects for Alzheimer's disease (AD). Yet the mechanism of this effect remains to be elucidated. The …
PMID: Chem Biol Interact. 2013 Oct 5 ;205(3):188-97. Epub 2013 Jul 16. PMID: 23867903 Abstract Title: Formononetin potentiates epirubicin-induced apoptosis via ROS production in HeLa cells in vitro. Abstract: The frequent development of multidrug resistance (MDR) hampers the efficacy of available anticancer drugs in treating cervical cancer. In this study, we aimed to use formononetin …
PMID: Inflammation. 2013 Dec ;36(6):1560-6. PMID: 23907652 Abstract Title: Formononetin inhibited the inflammation of LPS-induced acute lung injury in mice associated with induction of PPAR gamma expression. Abstract: Formononetin has shown a variety of pharmacologic properties including anti-inflammatory effect. In the present study, we analyzed the role of formononetin in acute lung injury induced by …
PMID: Tumour Biol. 2014 Mar ;35(3):2279-84. Epub 2013 Nov 24. PMID: 24272199 Abstract Title: In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa. Abstract: Worldwide, cervical cancer (CC) is the third most common malignancy in women, and it remains a leading cause of cancer-related death of women. Genomic …
PMID: J Neurol Sci. 2014 Mar 15 ;338(1-2):112-7. Epub 2013 Dec 27. PMID: 24411660 Abstract Title: Formononetin protects TBI rats against neurological lesions and the underlying mechanism. Abstract: Traumatic brain injury (TBI) is a major cause of disability or death worldwide, especially in the young. Thus, effective medication with few side effects needs to be …
PMID: Pharm Biol. 2013 Dec 20. Epub 2013 Dec 20. PMID: 24359236 Abstract Title: Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway. Abstract: Abstract Context: Formononetin, an isoflavone, can inhibit the proliferation of cancer cells, including those of the prostate. However, its antitumor mechanism remains unclear. …
Health Time