PMID: Cell Physiol Biochem. 2014 ;34(3):637-45. Epub 2014 Aug 12. PMID: 25170541 Abstract Title: The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways. Abstract: BACKGROUND: Previous studies have shown that some phytoestrogens inhibits proliferation and induces apoptosis in estrogen-dependent cancers via estrogen receptor (ER)-mediated signaling pathway. In …
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Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells.
PMID: Cell Physiol Biochem. 2014 ;34(4):1351-8. Epub 2014 Oct 2. PMID: 25301361 Abstract Title: Formononetin promotes cell cycle arrest via downregulation of Akt/Cyclin D1/CDK4 in human prostate cancer cells. Abstract: BACKGROUND: Formononetin is an O-methylated isoflavone isolated from the root of Astragalus membranaceus. It has already been reported that formononetin could inhibit cell proliferation and …
Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis.
PMID: Int J Clin Exp Pathol. 2014 ;7(12):8453-61. Epub 2014 Dec 1. PMID: 25674209 Abstract Title: Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis. Abstract: Formononetin is a novel herbal isoflavonoid isolated from Astragalus membranaceus and possesses antitumorigenic properties. In the present study, we investigated …
Formononetin inhibits enterovirus 71 replication.
PMID: Virol J. 2015 Mar 1 ;12:35. Epub 2015 Mar 1. PMID: 25890183 Abstract Title: Formononetin inhibits enterovirus 71 replication by regulating COX- 2/PGE₂ expression. Abstract: BACKGROUND: The activation of ERK, p38 and JNK signal cascade in host cells has been demonstrated to up-regulate of enterovirus 71 (EV71)-induced cyclooxygenase-2 (COX-2)/ prostaglandins E2 (PGE₂) expression which …
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Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5.
PMID: Int J Clin Exp Pathol. 2015 ;8(6):6434-41. Epub 2015 Jun 1. PMID: 26261519 Abstract Title: Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5. Abstract: Chemoresistance is a major obstacle to successful chemotherapy for glioma. Formononetin is a novel herbal isoflavonoid isolated from Astragalus membranaceus and possesses antitumorigenic …
Formononetin has inhibitory effects on the proliferation of U2SO cells.
PMID: Cell Physiol Biochem. 2015 ;37(3):933-9. Epub 2015 Sep 18. PMID: 26381132 Abstract Title: Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo. Abstract: BACKGROUND/AIMS: Phytoestrogens are known to prevent tumor progression by inhibiting proliferation and inducing apoptosis in cancer cells. …
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Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models.
PMID: Oncotarget. 2015 Dec 29 ;6(42):44563-78. PMID: 26575424 Abstract Title: Formononetin, a novel FGFR2 inhibitor, potently inhibits angiogenesis and tumor growth in preclinical models. Abstract: Most anti-angiogenic therapies currently being evaluated in clinical trials target vascular endothelial growth factor (VEGF) pathway, however, the tumor vasculature can acquire resistance to VEGF-targeted therapy by shifting to other …
These findings demonstrate that formononetin exerted the hair regrowth effect on hair loss.
PMID: Planta Med. 2016 Jan ;82(1-2):65-9. Epub 2016 Jan 12. PMID: 26756818 Abstract Title: Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis. Abstract: Formononetin is one of the main components of red clover plants and its role on hair regrowth against hair loss has not been established yet. In the present study, we …
Isoflavone formononetin from red propolis acts as a fungicide against Candida sp.
PMID: Braz J Microbiol. 2016 Jan-Mar;47(1):159-66. Epub 2016 Jan 27. PMID: 26887239 Abstract Title: Isoflavone formononetin from red propolis acts as a fungicide against Candida sp. Abstract: A bioassay-guided fractionation of two samples of Brazilian red propolis (from Igarassu, PE, Brazil, hereinafter propolis 1 and 2) was conducted in order to determine the components responsible …
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Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice.
PMID: Exp Biol Med (Maywood). 2017 01 ;242(2):223-230. Epub 2016 Jul 24. PMID: 27412955 Abstract Title: Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice. Abstract: The aim of this study was to investigate the anti-hyperglycemic activity and mechanism of formononetin in alloxan-induced type 1 diabetic mice by determining its effect on some diabetes-related …
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