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PMID:  Food Funct. 2017 Mar 22 ;8(3):1061-1066. PMID: 28139790 Abstract Title:  Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN. Abstract:  The isoflavone formononetin is the main active component of Astragalus membranaceus and possesses anti-tumorigenic properties. However, the role of formononetin in human bladder cancer (BCa) has not been …

Continue reading “Formononetin inhibits human bladder cancer cell proliferation and invasiveness.”

PMID:  PLoS One. 2017 ;12(2):e0170900. Epub 2017 Feb 24. PMID: 28234915 Abstract Title:  Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity. Abstract:  To examine the effects of formononetin (FMN) on Acetaminophen (APAP)-induced liver injury in vitro and in vivo. Human non-tumor hepatic cells LO2 were pretreated with either vehicle or FMN (20, 40μM), for …

Continue reading “Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.”

PMID:  Toxicol Appl Pharmacol. 2017 07 1 ;326:15-24. Epub 2017 Apr 13. PMID: 28414026 Abstract Title:  Targeting Oct2 and P53: Formononetin prevents cisplatin-induced acute kidney injury. Abstract:  Nephrotoxicity is one of major side effects of cisplatin in chemotherapy. Therefore, there is an urgent medical need to develop drugs that may protect kidney from toxicity. In …

Continue reading “Formononetin prevents cisplatin-induced acute kidney injury.”

PMID:  Biosci Biotechnol Biochem. 2018 Jan ;82(1):57-64. Epub 2017 Dec 1. PMID: 29191087 Abstract Title:  Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer's disease. Abstract:  Alzheimer's disease (AD) is the most common cause of dementia among elderly population. Derangedβ-amyloid (Aβ) trafficking across the blood-brain barrier is known to …

Continue reading “Neuroprotective effect of formononetin in ameliorating learning and memory impairment in mouse model of Alzheimer’s disease.”

PMID:  Exp Ther Med. 2017 Dec ;14(6):6201-6206. Epub 2017 Oct 12. PMID: 29250144 Abstract Title:  Formononetin ameliorates mast cell-mediated allergic inflammation via inhibition of histamine release and production of pro-inflammatory cytokines. Abstract:  Various allergic diseases cause allergic inflammation, which is mediated by mast cells. The current study investigated the anti-allergic inflammatory effects of formononetin and …

Continue reading “Formononetin ameliorated mast cell-mediated allergic inflammation.”

PMID:  Am J Transl Res. 2017 ;9(12):5653-5661. Epub 2017 Dec 15. PMID: 29312517 Abstract Title:  Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury in rats. Abstract:  Oxidative stress has been considered a major contributing factor to traumatic brain injury (TBI). Formononetin, a phytoestrogen that belongs …

Continue reading “Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury.”

PMID:  Mediators Inflamm. 2018 ;2018:3048532. Epub 2018 Jan 8. PMID: 29507526 Abstract Title:  Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway. Abstract:  Formononetin is a kind of isoflavone compound and has been reported to possess anti-inflammatory properties. In this present study, we aimed to explore the protective effects of …

Continue reading “Formononetin administration ameliorates dextran sulfate sodium-induced acute colitis.”

Although cannabidiol (CBD) doesn’t make people feel high like THC does, it’s causing quite a buzz among scientists, health professionals, and medical marijuana patients. But how does CBD work in the body? CBD-rich products are used to treat a wide range of conditions: chronic pain, cancer, Crohn’s, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, anxiety, antibiotic-resistant …

Continue reading “[Info-graphic] The Science Of How CBD Works In The Body”

PMID:  Biol Pharm Bull. 2018 Aug 1 ;41(8):1194-1202. Epub 2018 May 29. PMID: 29848900 Abstract Title:  Synergistic Anticancer Effects of Formononetin and Temozolomide on Glioma C6 Cells. Abstract:  Temozolomide (TMZ) is currently the first-line drug used for clinical postoperative or non-surgical chemotherapy for glioma, but acquired and intrinsic resistance to TMZ limits its application. The …

Continue reading “Synergistic anticancer effects of formononetin and temozolomide on glioma C6 cells.”

PMID:  Int J Mol Sci. 2018 Mar 12 ;19(3). Epub 2018 Mar 12. PMID: 29534504 Abstract Title:  Inhibition of Intracellular ROS Accumulation by Formononetin Attenuates Cisplatin-Mediated Apoptosis in LLC-PK1 Cells. Abstract:  Cisplatin is a well-known anticancer drug frequently used for treating solid tumors, including ovarian, testicular, bladder, and cervical tumors. However, usage of cisplatin has …

Continue reading “Formononetin may be a possible option to prevent nephrotoxicity induced by cisplatin during treatment for cervical cancer.”