PMID: Mol Med Rep. 2018 Jun ;17(6):7721-7729. Epub 2018 Apr 5. PMID: 29620230 Abstract Title: Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways. Abstract: Formononetin (Form), a phytoestrogen extracted from the roots of Astragalus membranaceus, is one of the fundamental herbs used in traditional …
Continue reading “Formononetin inhibits colon carcinoma cell growth and invasion.”
PMID: J Ethnopharmacol. 2018 Jul 15 ;221:91-99. Epub 2018 Apr 13. PMID: 29660466 Abstract Title: Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells. Abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Astragalus membranaceus which was originally described in the Shennong's Classic of Materia Medica, the earliest complete Pharmacopoeia of China written from the Warring …
Continue reading “Formononetin inhibits proliferation and metastasis of ovarian cancer cells.”
PMID: J Cell Biochem. 2018 09 ;119(9):7377-7387. Epub 2018 May 15. PMID: 29761845 Abstract Title: The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation. Abstract: Formononetin is an isoflavone that is extracted from red clovers or soy. It has anti-oxidant, anti-proliferative, and anti-tumor …
PMID: Biomed Pharmacother. 2018 Oct ;106:349-354. Epub 2018 Jul 11. PMID: 29966980 Abstract Title: Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons. Abstract: Traumatic brain injury (TBI) refers to external force-induced brain damage, characterized with necrosis and cell loss in cerebral cortex. Interestingly, a plant-extract named formononetin (FN) …
Continue reading “Neuroprotective effect of formononetin against traumatic brain injury.”
PMID: Front Pharmacol. 2018 ;9:739. Epub 2018 Jul 18. PMID: 30072892 Abstract Title: Formononetin Treatment in Type 2 Diabetic Rats Reduces Insulin Resistance and Hyperglycemia. Abstract: Type 2 diabetic mellitus is a multifactorial metabolic disorder affecting huge population around the world. This indicates that there is an urgent unmet need of cost effective, new treatment …
PMID: Biomed Pharmacother. 2018 Oct ;106:1250-1257. Epub 2018 Jul 20. PMID: 30119194 Abstract Title: The protective effect of formononetin on cognitive impairment in streptozotocin (STZ)-induced diabetic mice. Abstract: The present study was aimed to elucidate the pharmacological effect of Formononetin (FMN) treatment on STZ-induced diabetic cognitive dysfunction. The diabetic model was induced by an intraperitoneally …
PMID: Mol Med Rep. 2018 Dec ;18(6):4821-4830. Epub 2018 Oct 10. PMID: 30320398 Abstract Title: Formononetin may protect aged hearts from ischemia/reperfusion damage by enhancing autophagic degradation. Abstract: Myocardial infarction is a leading cause of mortality worldwide, and timely blood/oxygen reperfusion may substantially improve the outcome of infarction. However, ischemia/reperfusion (I/R) may cause severe side …
PMID: Drug Des Devel Ther. 2018 ;12:3675-3684. Epub 2018 Nov 1. PMID: 30464399 Abstract Title: Formononetin induces vasorelaxation in rat thoracic aorta via regulation of the PI3K/PTEN/Akt signaling pathway. Abstract: Background: Formononetin (FMN) is an isoflavone that produces arterial vasodilation. However, the underlying molecular mechanisms are unclear.Purpose: The purpose of this study was to explore …
PMID: Biomed Pharmacother. 2019 Jan ;109:2084-2089. Epub 2018 Nov 26. PMID: 30551465 Abstract Title: Formononetin and metformin act synergistically to inhibit growth of MCF-7 breast cancer cells in vitro. Abstract: Many breast cancer patients suffer from obvious side effects induced by chemotherapy. Formononetin (FM), one kind ingredient of Chinese herbal medicine, has been suggested to …
PMID: Life Sci. 2019 Feb 15 ;219:109-121. Epub 2019 Jan 11. PMID: 30641085 Abstract Title: Formononetin attenuates kidney damage in type 2 diabetic rats. Abstract: AIM: Diabetic nephropathy is the commonly developed complication of vasculature in type 2 diabetic patients. Chronic hyperglycemia leads to nephropathy in diabetics because of the formation of excessive reactive oxygen …
Health Time