PMID: Antioxidants (Basel). 2019 Sep 26 ;8(10). Epub 2019 Sep 26. PMID: 31561418 Abstract Title: Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats. Abstract: Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX …
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Biochanin A may represent a breast cancer preventive agent, either administered alone or in combination with other flavonoids.
PMID: Pharm Res. 2008 Sep ;25(9):2158-63. Epub 2008 May 3. PMID: 18454305 Abstract Title: Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Abstract: PURPOSE: Our objective was to determine the effect of the flavonoid biochanin A (BCA), administered alone or in combination with the flavonoids quercetin and epigallocatechin-3-gallate (EGCG), on the …
Inhibition of angiogenesis and inflammation by an extract of red clover.
PMID: Phytomedicine. 2009 Dec ;16(12):1083-8. Epub 2009 Aug 7. PMID: 19665361 Abstract Title: Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.). Abstract: Antiangiogenic compounds are gaining more and more interest as a new approach in the prevention and treatment of cancer and inflammatory diseases. The objective of this study …
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Biochanin A can selectively target cancer cells and inhibit multiple signaling pathways in HER-2-positive breast cancer cells.
PMID: J Oncol. 2009 ;2009:121458. Epub 2010 Feb 11. PMID: 20169097 Abstract Title: Biochanin A Modulates Cell Viability, Invasion, and Growth Promoting Signaling Pathways in HER-2-Positive Breast Cancer Cells. Abstract: Overexpression of HER-2 receptor is associated with poor prognosis and aggressive forms of breast cancer. Scientific literature indicates a preventive role of isoflavones in cancer. …
There was synergy of biochanin A and ciprofloxacin against clinical isolates of Staphylococcus aureus.
PMID: Molecules. 2011 Aug 5 ;16(8):6656-66. Epub 2011 Aug 5. PMID: 25134769 Abstract Title: In Vitro Synergy of Biochanin A and Ciprofloxacin against Clinical Isolates of Staphylococcus aureus. Abstract: Many clinical isolates of Staphylococcus aureus (S. aureus) are resistant to numerous antimicrobials, including the fluoroquinolones (FQs). Flavonoids such as biochanin A (BCA) are compounds that …
The dietary isoflavone biochanin-A sensitizes prostate cancer cells to TRAIL-induced apoptosis.
PMID: Urol Oncol. 2013 Apr ;31(3):331-42. Epub 2011 Jul 30. PMID: 21803611 Abstract Title: The dietary isoflavone biochanin-A sensitizes prostate cancer cells to TRAIL-induced apoptosis. Abstract: Biochanin-A, a major dietary isoflavone in soy and red clover, possesses anticancer and chemopreventive properties. Induction of apoptosis by naturally occurring dietary agents is an important event for cancer …
Biochanin A has potential antihyperglycemic activity.
PMID: Eur J Pharmacol. 2012 Feb 15 ;676(1-3):89-94. Epub 2011 Dec 8. PMID: 22178203 Abstract Title: Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats. Abstract: The study was designed to investigate the antihyperglycemic effect of biochanin A on streptozotocin-diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, …
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Extremely low frequency electromagnetic fields may induce anxiety-like behavior and oxidative stress.
PMID: Behav Brain Res. 2019 02 1 ;359:630-638. Epub 2018 Oct 2. PMID: 30290199 Abstract Title: Effects of exposure to extremely low-frequency electromagnetic fields on spatial and passive avoidance learning and memory, anxiety-like behavior and oxidative stress in male rats. Abstract: There are many controversies about the safety of extremely low-frequency electromagnetic field (ELF-EMF) on …
Extremely low-frequency electric fields at different intensities may induce lipid peroxidation.
PMID: Neuroscience. 2014 Jul 11 ;272:154-66. Epub 2014 May 6. PMID: 24811084 Abstract Title: Effects of extremely low-frequency electric fields at different intensities and exposure durations on mismatch negativity. Abstract: The effects of extremely low-frequency electric fields (ELF-EFs, 3-300Hz) on lipid peroxidation levels and antioxidant enzyme activities have been shown in many tissues and plasma …
Exposure to static magnetic field causes accumulation of reactive oxygen species in Vicia faba L. and natural radioactivity of soil exaggerates oxidative stress.
PMID: Mutat Res. 2012 Jan 24 ;741(1-2):116-21. Epub 2011 Nov 16. PMID: 22108253 Abstract Title: Oxidative stress in broad bean (Vicia faba L.) induced by static magnetic field under natural radioactivity. Abstract: The investigation was performed to evaluate the influence of the static magnetic field on oxidative stress in Vicia faba cultivated in soil from …
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