PMID: Oncol Lett. 2017 Nov ;14(5):5989-5993. Epub 2017 Sep 14. PMID: 29113236 Abstract Title: Biochanin A induces anticancer effects in SK-Mel-28 human malignant melanoma cells via induction of apoptosis, inhibition of cell invasion and modulation of NF-κB and MAPK signaling pathways. Abstract: The present study aimed to investigate the antitumor activity of Biochanin A in …
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Biochanin A extirpates the epithelial-mesenchymal transition in a human lung cancer.
PMID: Exp Ther Med. 2018 Mar ;15(3):2830-2836. Epub 2018 Jan 10. PMID: 29456686 Abstract Title: Biochanin A extirpates the epithelial-mesenchymal transition in a human lung cancer. Abstract: The natural iso-flavonoid, biochanin A, is categorized as a phytoestrogen and has been demonstrated to exhibit various pharmacological properties. However, no effects of biochanin A on lung cancer …
The results suggest biochanin A as a nephroprotective agent against cisplatin toxicity.
PMID: Int Immunopharmacol. 2018 Aug ;61:8-19. Epub 2018 May 21. PMID: 29793166 Abstract Title: Renoprotective effect of the isoflavonoid biochanin A against cisplatin induced acute kidney injury in mice: Effect on inflammatory burden and p53 apoptosis. Abstract: Cisplatin is a potent widely-used chemotherapeutics; however, its clinical use is associated with nephrotoxicity. Renoprotective approaches are being …
Biochanin A has suppressive effects on osteosarcoma through regulating cell proliferation, apoptosis, invasion, and migration.
PMID: Pharmazie. 2018 06 1 ;73(6):335-341. PMID: 29880086 Abstract Title: The effect of biochanin A on cell growth, apoptosis, and migration in osteosarcoma cells. Abstract: Biochanin A has been reported to be associated to tumour cell proliferation, apoptosis and drug resistance in hepatocellular carcinoma, prostate cancer, and colorectal cancer, etc, while the relation of biochanin …
Biochanin A reduces inflammatory injury and neuronal apoptosis following subarachnoid hemorrhage.
PMID: Behav Neurol. 2018 ;2018:1960106. Epub 2018 Jun 3. PMID: 29971136 Abstract Title: Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-B Pathway. Abstract: Inflammatory injury and neuronal apoptosis participate in the period of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Suppression of inflammation has recently been …
Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway.
PMID: Oncol Res. 2018 Jul 23. Epub 2018 Jul 23. PMID: 30037363 Abstract Title: Biochanin A regulates the growth and migration of NSCLC through suppressing the VEGF/VEGFR2 signaling pathway. Abstract: Non-small cell lung cancer (NSCLC) is the most common lung cancer with 15.9% of predicted 5-year survival rate which represents extremely poor prognosis. In this …
Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes.
PMID: Biomed Pharmacother. 2018 Nov ;107:1119-1127. Epub 2018 Aug 27. PMID: 30257324 Abstract Title: Biochanin A improves insulin sensitivity and controls hyperglycemia in type 2 diabetes. Abstract: Biochanin A (5,7-Dihydroxy-4'-methoxyisoflavone) is an O-methylated isoflavone known for its anti-inflammatory, lipid lowering and anti-cancer activity. The current study was designed to find out antidiabetic efficacy of Biochanin …
Biochanin A is an attractive compound for preventing 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced wasting syndrome.
PMID: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2019 ;54(9):865-873. Epub 2019 Apr 20. PMID: 31007129 Abstract Title: Biochanin A prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced adipocyte dysfunction in cultured 3T3-L1 cells. Abstract: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant. TCDD accumulates in the food chain, mainly in the fatty tissues of the human body where …
Administration of biochanin A can improve and postpone retinopathy.
PMID: Can J Diabetes. 2018 Dec ;42(6):639-644. Epub 2018 Apr 3. PMID: 30054234 Abstract Title: Effect of Biochanin A on Retina Levels of Vascular Endothelial Growth Factor, Tumor Necrosis Factor-Alpha and Interleukin-1Beta in Rats With Streptozotocin-Induced Diabetes. Abstract: OBJECTIVES: Without proper medication for the treatment of diabetic retinopathy, retinal cells become malnourished and degenerate, which …
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Formononetin and biochanin A protects against ritonavir induced hepatotoxicity.
PMID: Life Sci. 2018 Nov 15 ;213:174-182. Epub 2018 Oct 13. PMID: 30326221 Abstract Title: Formononetin and biochanin A protects against ritonavir induced hepatotoxicity via modulation of NfκB/pAkt signaling molecules. Abstract: AIMS: Ritonavir (RIT) is a human immune deficiency virus (HIV) protease inhibitor (PI) active against HIV-1 and HIV-2. Among various adverse effects of PIs, …
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