PMID: Ecotoxicol Environ Saf. 2019 Dec 15 ;185:109720. Epub 2019 Oct 1. PMID: 31585392 Abstract Title: Selenium modulated gut flora and promoted decomposition of methylmercury in methylmercury-poisoned rats. Abstract: INTRODUCTION: Selenium plays important roles in antagonizing the toxicity of methylmercury. The underlying mechanism for the antagonism between Se and MeHg is still not fully understood.OBJECTIVE: …
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Sesamin exerts anti-aging effects in the muscles, brain and midgut by inducing antioxidative and DNA repair genes.
PMID: Eur Rev Med Pharmacol Sci. 2019 Feb ;23(4):1826-1839. PMID: 30840309 Abstract Title: Sesamin suppresses aging phenotypes in adult muscular and nervous systems and intestines in a Drosophila senescence-accelerated model. Abstract: OBJECTIVE: Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects. Previous studies have demonstrated that sesamin extends the lifespan of Drosophila and Caenorhabditis …
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Sesamin could be a promising potential therapeutic agent against diabetes-associated cognitive decline.
PMID: Life Sci. 2019 Aug 1 ;230:169-177. Epub 2019 May 29. PMID: 31150685 Abstract Title: Sesamin: A promising protective agent against diabetes-associated cognitive decline in rats. Abstract: AIMS: Hippocampal oxidative stress and apoptosis of CA1 neurons play significant roles in the pathophysiology of diabetes-associated cognitive decline (DACD). The present study was aimed to elucidate the …
Sesamin promotes osteoblastic differentiation and protects rats from osteoporosis.
PMID: Med Sci Monit. 2019 Jul 17 ;25:5312-5320. Epub 2019 Jul 17. PMID: 31314750 Abstract Title: Sesamin Promotes Osteoblastic Differentiation and Protects Rats from Osteoporosis. Abstract: BACKGROUND Osteoporosis is a common osteopathy, resulting in fractures, especially in elder people. Sesamin has many pharmacological effects, including supplying calcium. However, how sesamin might prevent osteoporosis is still …
Sesamin enhances Nrf2-mediated protective defense against oxidative stress and inflammation in colitis.
PMID: Oxid Med Cell Longev. 2019 ;2019:2432416. Epub 2019 Aug 26. PMID: 31534619 Abstract Title: Sesamin Enhances Nrf2-Mediated Protective Defense against Oxidative Stress and Inflammation in Colitis via AKT and ERK Activation. Abstract: Ulcerative colitis (UC) is a major form of inflammatory bowel disease (IBD) with high incidence and prevalence in many countries. Patients with …
Sesamin has potential for use as a skin protection agent in antiphotodamage and skin care products.
PMID: Biomolecules. 2019 Sep 12 ;9(9). Epub 2019 Sep 12. PMID: 31547364 Abstract Title: Protective Effects of Sesamin against UVB-Induced Skin Inflammation and Photodamage In Vitro and In Vivo. Abstract: Ultraviolet (UV) exposure has been demonstrated as the most critical factor causing extrinsic skin aging and inflammation. This study explored the protective effects and mechanisms …
The protective role of lutein on isoproterenol-induced cardiac failure.
PMID: Pharm Biol. 2019 Dec ;57(1):529-535. PMID: 31411934 Abstract Title: The protective role of lutein on isoproterenol-induced cardiac failure rat model through improving cardiac morphology, antioxidant status via positively regulating Nrf2/HO-1 signalling pathway. Abstract: Lutein (LU) is a major carotenoid with various pharmacological activities including anti-inflammatory, antioxidant and anti-apoptosis.The cardioprotective efficacy of LU was determined …
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There is ample evidence suggesting that sesamol possesses potent anti-cancer properties in vitro and in vivo.
PMID: Eur J Pharmacol. 2019 Jul 15 ;855:75-89. Epub 2019 May 4. PMID: 31063773 Abstract Title: Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action. Abstract: Sesamol is a natural phenolic compound and a major lignan isolated from sesame seeds (Sesamum indicum) and sesame oil. The therapeutic potential of …
Coenzyme Q10 supplementation in fibrosis and aging.
PMID: Adv Exp Med Biol. 2019 ;1178:103-112. PMID: 31493224 Abstract Title: Coenzyme Q10 Supplementation in Fibrosis and Aging. Abstract: Coenzyme Q10 (CoQ10) is a vitamin-like substance which functions as an electron carrier within the mitochondrial respiratory chain, as well as serving as an important intracellular antioxidant. Most of the body's CoQ10 requirements are met by …
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