PMID: J Ovarian Res. 2018 Nov 19 ;11(1):93. Epub 2018 Nov 19. PMID: 30454003 Abstract Title: Luteolin sensitizes the antitumor effect of cisplatin in drug-resistant ovarian cancer via induction of apoptosis and inhibition of cell migration and invasion. Abstract: Luteolin, a polyphenolic flavone, has been demonstrated to exert anti-tumor activity in various cancer types. Cisplatin …
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This review concludes that luteolin can be a molecule for the therapy of both cancer and diabetes by acting on broad signaling pathway.
PMID: Brief Funct Genomics. 2018 07 22 ;18(4):230-239. PMID: 30462152 Abstract Title: Can luteolin be a therapeutic molecule for both colon cancer and diabetes? Abstract: Diabetes and colon cancer are the leading cause of mortality worldwide. According to World Health Organization, the number of patients with diabetes and cancer is going to be elevated by …
Pharmacodynamic effect of luteolin micelles on alleviating cerebral ischemia reperfusion injury.
PMID: Pharmaceutics. 2018 Nov 29 ;10(4). Epub 2018 Nov 29. PMID: 30501051 Abstract Title: Pharmacodynamic Effect of Luteolin Micelles on Alleviating Cerebral Ischemia Reperfusion Injury. Abstract: Oxidative stress and inflammation are important mechanisms of cerebral ischemia reperfusion (IR) injury. Luteolin (Lu), one of the major active components in the classical Tibetan prescription, which has been …
Docking study of flavonoid derivatives as potent inhibitors of influenza H1N1 virus neuraminidase.
PMID: Biomed Rep. 2019 Jan ;10(1):33-38. Epub 2018 Nov 23. PMID: 30588301 Abstract Title: Docking study of flavonoid derivatives as potent inhibitors of influenza H1N1 virus neuraminidase. Abstract: Influenza type A is considered as a severe public health concern. The mechanism of drugs applied for the control of this virus depends on two surface glycoproteins …
Luteolin suppresses lipopolysaccharide‑induced cardiomyocyte hypertrophy and autophagy in vitro.
PMID: Mol Med Rep. 2019 Mar ;19(3):1551-1560. Epub 2019 Jan 2. PMID: 30628693 Abstract Title: Luteolin suppresses lipopolysaccharide‑induced cardiomyocyte hypertrophy and autophagy in vitro. Abstract: Luteolin (LTL) serves essential roles in a wide variety of biological processes. Lipopolysaccharide (LPS) can lead to myocardial hypertrophy and autophagy. However, the roles of LTL on LPS‑induced cardiomyocyte hypertrophy and …
Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome.
PMID: Neural Regen Res. 2019 Apr ;14(4):613-620. PMID: 30632501 Abstract Title: Luteolin induces hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome. Abstract: Studies have shown that the natural flavonoid luteolin has neurotrophic activity. In this study, we investigated the effect of luteolin in a mouse model of Down syndrome. Ts65Dn mice, which are …
Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression.
PMID: J Nat Med. 2019 Jun ;73(3):487-496. Epub 2019 Feb 13. PMID: 30758716 Abstract Title: Luteolin decreases the yield of influenza A virus in vitro by interfering with the coat protein I complex expression. Abstract: Influenza is an acute transmissible respiratory infectious disease in humans and animals with high morbidity and mortality. It was reported …
The results of the present study indicated that luteolin may inhibit breast cancer cell growth by targeting hTERT.
PMID: Oncol Lett. 2019 Apr ;17(4):3842-3850. Epub 2019 Feb 19. PMID: 30930986 Abstract Title: Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase. Abstract: Luteolin is a flavonoid, which has been extensively investigated due to its antitumor effects; however, the underlying mechanisms of its action …
Luteolin attenuates high glucose-induced podocyte injury via suppressing NLRP3 inflammasome pathway.
PMID: Life Sci. 2019 May 15 ;225:1-7. Epub 2019 Mar 30. PMID: 30935950 Abstract Title: Luteolin attenuates high glucose-induced podocyte injury via suppressing NLRP3 inflammasome pathway. Abstract: AIMS: Diabetic nephropathy is a growing health concern, which is reported to be associated with inflammation. Luteolin has been explored for the treatment of some diabetic complications. Although …
This review will open new dimensions for luteolin as an effective and safe therapeutic agent in diminishing breast cancer.
PMID: Phytomedicine. 2019 Jun ;59:152883. Epub 2019 Mar 10. PMID: 30986716 Abstract Title: Apoptosis induced by luteolin in breast cancer: Mechanistic and therapeutic perspectives. Abstract: BACKGROUND: Breast cancer is worldwide commonly found malignancy in women and effective treatment is regarded as a huge clinical challenge even in the presence of several options. Extensive literature is …
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