PMID: Nutrients. 2019 Apr 2 ;11(4). Epub 2019 Apr 2. PMID: 30987009 Abstract Title: Luteolin Shifts Oxaliplatin-Induced Cell Cycle Arrest at G₀/G₁ to Apoptosis in HCT116 Human Colorectal Carcinoma Cells. Abstract: Certain antioxidative flavonoids are known to activate nuclear factor E2-related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidants and detoxifying response and …
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These results provide insight into the mechanism that underlies the anticancer effects of luteolin on colon cancer.
PMID: Exp Mol Med. 2019 Apr 15 ;51(4):40. Epub 2019 Apr 15. PMID: 30988303 Abstract Title: Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells. Abstract: Luteolin, a dietary flavone, modulates various signaling pathways involved in carcinogenesis. In this …
These findings illustrate that luteolin may be a potential drug for glioma treatment.
PMID: Onco Targets Ther. 2019 ;12:2383-2396. Epub 2019 Mar 28. PMID: 30992674 Abstract Title: Luteolin suppresses tumor proliferation through inducing apoptosis and autophagy via MAPK activation in glioma. Abstract: Purpose: Glioma is a malignant tumor that originates in the brain and spine and is difficult to be completely removed. Though glioma patients receive active treatment, …
Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses.
PMID: Phytomedicine. 2019 Jun ;59:152774. Epub 2018 Nov 28. PMID: 31009852 Abstract Title: Luteolin protects against diabetic cardiomyopathy by inhibiting NF-κB-mediated inflammation and activating the Nrf2-mediated antioxidant responses. Abstract: BACKGROUND: Diabetes mellitus is a well-known risk factor for the development of heart failure. Inflammation and oxidative stress play a key role in the development of …
Luteolin successfully improved periodontal health in a ligature-induced experimental periodontitis.
PMID: J Periodontol. 2019 May 22. Epub 2019 May 22. PMID: 31115905 Abstract Title: The effect of luteolin in prevention of periodontal disease in Wistar rats. Abstract: BACKGROUND: Periodontal disease is the chronic infectious disease of the periodontium. Because of irreversibility, prevention of disease is one of the most important goals of periodontal treatment. The …
Flavonoids showed anticancer effects on the ovarian cancer cells.
PMID: Biomed Pharmacother. 2019 Aug ;116:109004. Epub 2019 May 22. PMID: 31128404 Abstract Title: Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion. Abstract: Flavonoids have been recently identified as a potential anticancer agent against various human epithelial cancers. In this study, the elucidation of …
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Luteolin may provide a promising preclinical therapeutic line in multiple sclerosis being anti-inflammatory, antiapoptotic, and neurotrophic agent.
PMID: IUBMB Life. 2019 Sep ;71(9):1401-1408. Epub 2019 Jun 11. PMID: 31185137 Abstract Title: The modulatory effects of luteolin on cyclic AMP/Ciliary neurotrophic factor signaling pathway in experimentally induced autoimmune encephalomyelitis. Abstract: Multiple sclerosis (MS) is considered to be an autoimmune disorder of the central nervous system (CNS) manifested by chronic inflammation. Although its etiology …
Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice.
PMID: Phytother Res. 2018 Sep ;32(9):1795-1802. Epub 2018 May 11. PMID: 29748995 Abstract Title: Apigenin inhibits growth of the Plasmodium berghei and disrupts some metabolic pathways in mice. Abstract: Due to the challenges in the control, prevention, and eradication of parasitic diseases like malaria, there is an urgent need to discover new therapeutic agents. Plant-derived …
Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters.
PMID: J Pharm Pharmacol. 2018 Sep ;70(9):1253-1261. Epub 2018 Jun 25. PMID: 29943490 Abstract Title: Co-administrating apigenin in a high-cholesterol diet prevents hypercholesterolaemia in golden hamsters. Abstract: OBJECTIVES: Hypercholesterolaemia is a major risk factor for developing atherosclerosis. Increased consumption of fruits and vegetables is recommended to hypercholesterolaemic patients. In this study, the hypocholesterolaemic effect of …
Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway.
PMID: Biomed Pharmacother. 2018 Sep ;105:1283-1290. Epub 2018 Jun 22. PMID: 30021365 Abstract Title: Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway. Abstract: Chronic dietary high fructose leads to various kinds of undesirable metabolic effects. Apigenin, a naturally occurring plant flavone, is plentiful in fruits and vegetables. The aim of this study …
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