PMID: Mol Med Rep. 2017 Dec ;16(6):8265-8276. Epub 2017 Sep 25. PMID: 28944916 Abstract Title: Total glucosides of paeony ameliorates TNBS‑induced colitis by modulating differentiation of Th17/Treg cells and the secretion of cytokines. Abstract: The imbalance between effector CD4+ T helper 17 (Th17) and regulatory CD4+ T cells (Treg) cells and their associated cytokines, have been …
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Total glucosides of paeony improves the immunomodulatory capacity of mesenchymal stem cells.
PMID: Biomed Pharmacother. 2018 Sep ;105:151-158. Epub 2018 May 29. PMID: 29852392 Abstract Title: Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus. Abstract: Mesenchymal stem cells (MSCs) have been used clinically and experimentally to relieve severe immune-related diseases due to their immunomodulatory properties, but …
The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells.
PMID: Mol Med Rep. 2018 Sep ;18(3):3332-3340. Epub 2018 Jul 30. PMID: 30066927 Abstract Title: The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway. Abstract: At present, cardiovascular disease is the global leading cause of mortality. Total paeony glycoside (TPG) is a traditional Chinese …
Synergistic and hepatoprotective effect of total glucosides of paeony on ankylosing spondylitis.
PMID: Front Pharmacol. 2019 ;10:231. Epub 2019 Mar 19. PMID: 30941036 Abstract Title: Synergistic and Hepatoprotective Effect of Total Glucosides of Paeony on Ankylosing Spondylitis: A Systematic Review and Meta-Analysis. Abstract: The objective of this systematic review was to conduct a meta-analysis of the efficacy and safety of total glucosides of paeony (TGP) for the …
Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis.
PMID: Drug Des Devel Ther. 2019 ;13:1969-1984. Epub 2019 Jun 17. PMID: 31354242 Abstract Title: Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis. Abstract: Total glucosides of paeony (TGP) have been confirmed to reduce hepatotoxicity caused by methotrexate (MTX) and leflunomide (LEF) in rheumatoid …
Total glycosides of paeony can be used to treat psoriasis with reduced adverse reactions and recurrence rates.
PMID: Phytomedicine. 2019 Apr 25 ;62:152940. Epub 2019 Apr 25. PMID: 31100680 Abstract Title: Total glucosides of paeony for the treatment of psoriasis: A systematic review and meta-analysis of randomized controlled trials. Abstract: BACKGROUND: Psoriasis is a common chronic relapsing immune-mediated inflammatory disease, the prevalence of which has increased in recent years. At present, there …
Sulforaphane could suppress the growth of nasopharyngeal carcinoma cells via the DNMT1/WIF1 axis.
PMID: Phytomedicine. 2019 Jul 29 ;63:153058. Epub 2019 Jul 29. PMID: 31394414 Abstract Title: Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis. Abstract: BACKGROUND: Sulforaphane (SFN), a natural compound present in cruciferous vegetable, has been shown to possess anti-cancer activities. Cancer stem cell (CSC) …
Sulforaphane inhibits the acquisition of tobacco smoke-induced lung cancer stem cell-like properties.
PMID: Theranostics. 2019 ;9(16):4827-4840. Epub 2019 Jul 9. PMID: 31367260 Abstract Title: Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Propertiesthe IL-6/ΔNp63α/Notch Axis. Abstract: Tobacco smoke (TS) critically contributes to the development of lung cancer; however, the underlying molecular mechanisms remain unclear. The induction of cancer stem cells (CSCs) by TS represents …
Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused.
PMID: Hum Cell. 2019 Oct ;32(4):403-410. Epub 2019 Jul 5. PMID: 31278688 Abstract Title: Sulforaphane inhibits the activation of hepatic stellate cell by miRNA-423-5p targeting suppressor of fused. Abstract: Liver fibrosis, a common pathological process in chronic liver diseases, is characterized by excessive accumulation of extracellular matrix proteins and considered as a wound healing response to …
Sulforaphane prevents retinal ganglion cell death and acts as a potent neuroprotective modulator in retinal ischemia/reperfusion injury.
PMID: Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419861777. PMID: 31266422 Abstract Title: Sulforaphane alleviates retinal ganglion cell death and inflammation by suppressing NLRP3 inflammasome activation in a rat model of retinal ischemia/reperfusion injury. Abstract: This study aims to study the potentials of sulforaphane (SFN) against retinal ischemia/reperfusion (I/R) injury. A rat retinal I/R injury method was …
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