PMID: Medicine (Baltimore). 2019 Oct ;98(40):e17126. PMID: 31577702 Abstract Title: N-acetyl cysteine inhibits lipopolysaccharide-mediated synthesis of interleukin-1β and tumor necrosis factor-α in human periodontal ligament fibroblast cells through nuclear factor-kappa B signaling. Abstract: BACKGROUND: The aim of this study was to investigate the role of n-acetyl cysteine (NAC) in the lipopolysaccharide (LPS)-mediated induction of tumor …
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Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer.
PMID: Surgery. 2019 Sep 11. Epub 2019 Sep 11. PMID: 31521320 Abstract Title: Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer. Abstract: BACKGROUND: Anaplastic thyroid cancer is an aggressive and fatal malignancy. Many advanced cancers are characterized by glucose dependency, leading to oxidative stress and cellular …
N-acetyl cysteine attenuates the sarcopenia and muscle apoptosis induced by chronic liver disease.
PMID: Curr Mol Med. 2019 Sep 17. Epub 2019 Sep 17. PMID: 31530262 Abstract Title: N-Acetyl Cysteine attenuates the sarcopenia and muscle apoptosis induced by chronic liver disease. Abstract: Sarcopenia is characterized by the loss of muscle mass and strength (muscle atrophy) because of aging or chronic diseases such as chronic liver disease (CLD). Different …
Bisdemethoxycurcumin possessed favorable cardioprotection in a Nrf2/HO-1-dependent manner.
PMID: Chem Res Toxicol. 2019 Sep 16 ;32(9):1871-1879. Epub 2019 Aug 22. PMID: 31402651 Abstract Title: Bisdemethoxycurcumin Protection of Cardiomyocyte Mainly Depends on Nrf2/HO-1 Activation Mediated by the PI3K/AKT Pathway. Abstract: Bisdemethoxycurcumin (BDMC) is one of three curcuminoids extracted from turmeric. Unlike the dominant ingredient curcumin with some intensive investigations, BDMC was recently reported to …
This study identified that BPA increased urinary excretion of vitamin D3 and decreased its concentration in blood.
PMID: Chemosphere. 2019 Aug 1 ;237:124469. Epub 2019 Aug 1. PMID: 31549635 Abstract Title: Effect of developmental exposure to bisphenol A on steroid hormone and vitamin D3 metabolism. Abstract: High exposure to bisphenol A (BPA) in children has been associated with the outcomes of several diseases, including those related to developmental problems. To elucidate the …
Perinatal exposure to BPA causes the development of NAFLD in both female and male offspring.
PMID: Front Endocrinol (Lausanne). 2019 ;10:620. Epub 2019 Sep 10. PMID: 31551937 Abstract Title: Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats. Abstract: Accumulating evidence suggests a role of bisphenol A (BPA) in non-alcoholic fatty liver disease (NAFLD), and its …
Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway.
PMID: J Biochem Mol Toxicol. 2019 Aug 30:e22389. Epub 2019 Aug 30. PMID: 31468582 Abstract Title: Gastrodin alleviates Tourette syndrome via Nrf-2/HO-1/HMGB1/NF-кB pathway. Abstract: The aim is to study the effects of gastrodin (GA) on striatal inflammation and oxidative stress in rats with Tourette syndrome (TS). The rat model of TS was induced by 3,3'-iminodipropionitrile. …
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Simvastatin impairs the inflammatory and repair phases of the post injury skeletal muscle regeneration.
PMID: Biomed Res Int. 2018 ;2018:7617312. Epub 2018 Nov 4. PMID: 30519583 Abstract Title: Simvastatin Impairs the Inflammatory and Repair Phases of the Postinjury Skeletal Muscle Regeneration. Abstract: Background: Recent clinical data have suggested that the chronic use of high-lipophilic statins impairs the regenerative capacity of skeletal muscle. Because this activity of statins is poorly …
Coenzyme Q10 protects against β-cell toxicity induced by pravastatin treatment of hypercholesterolemia.
PMID: J Cell Physiol. 2019 Jul ;234(7):11047-11059. Epub 2018 Dec 7. PMID: 30536661 Abstract Title: Coenzyme Qprotects againstβ-cell toxicity induced by pravastatin treatment of hypercholesterolemia. Abstract: New onset of diabetes is associated with the use of statins. We have recently demonstrated that pravastatin-treated hypercholesterolemic LDL receptor knockout (LDLr) mice exhibit reductions in insulin secretion and increased …
In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in male rats.
PMID: Toxicol Appl Pharmacol. 2019 02 15 ;365:112-123. Epub 2019 Jan 11. PMID: 30639414 Abstract Title: In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat. Abstract: We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowers fetal lipids …
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